Epigenetic drift, epigenetic clocks and cancer risk

Epigenetic-aging-signature to determine age in different tissues

(2016) Carmen M. Koch et al.   Aging-US

Epigenetic aging: insights from network biology

(2016) Andrew E. Teschendorff   Aging-US

Accelerated epigenetic aging in Down syndrome

(2015) Steve Horvath et al.   AGING CELL

DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative

(2015) Morgan E. Levine et al.   Aging-US

DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors

(2015) Tali Mazor et al.   CANCER CELL

Longitudinal Study of DNA Methylation of Inflammatory Genes and Cancer Risk

(2015) B. T. Joyce et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer

(2015) Peter D. Adams et al.   Cell Stem Cell

Smoking-Associated DNA Methylation Biomarkers and Their Predictive Value for All-Cause and Cardiovascular Mortality

(2015) Yan Zhang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

F2RL3methylation, lung cancer incidence and mortality

(2015) Yan Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936

(2015) Riccardo E Marioni et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

HIV-1 Infection Accelerates Age According to the Epigenetic Clock

(2015) Steve Horvath et al.   JOURNAL OF INFECTIOUS DISEASES

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Clock-like mutational processes in human somatic cells

(2015) Ludmil B Alexandrov et al.   NATURE GENETICS

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

(2015) C. Tomasetti et al.   SCIENCE

Impact of Maternal Diet on the Epigenome during In Utero Life and the Developmental Programming of Diseases in Childhood and Adulthood

(2015) Ho-Sun Lee   Nutrients

Omic personality: implications of stable transcript and methylation profiles for personalized medicine

(2015) Rubina Tabassum et al.   Genome Medicine

An Integrative Multi-scale Analysis of the Dynamic DNA Methylation Landscape in Aging

(2015) Tian Yuan et al.   PLoS Genetics

Epigenetic Aging Signatures Are Coherently Modified in Cancer

(2015) Qiong Lin et al.   PLoS Genetics

Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis

(2015) Karin van Veldhoven et al.   Clinical Epigenetics

DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies

(2015) Xu Gao et al.   Clinical Epigenetics

Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin

(2015) Amy R Vandiver et al.   GENOME BIOLOGY

Erratum to: DNA methylation age of human tissues and cell types

(2015) Steve Horvath   GENOME BIOLOGY

DNA methylation age of blood predicts all-cause mortality in later life

(2015) Riccardo E Marioni et al.   GENOME BIOLOGY

Correlation of Smoking-Associated DNA Methylation Changes in Buccal Cells With DNA Methylation Changes in Epithelial Cancer

(2015) Andrew E. Teschendorff et al.   JAMA Oncology

Acceleration of Age-Associated Methylation Patterns in HIV-1-Infected Adults

(2015) Tammy M. Rickabaugh et al.   PLoS One

Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs

(2014) Wilma T. Steegenga et al.   AGE

Epigenome-wide methylation in DNA from peripheral blood as a marker of risk for breast cancer

(2014) Gianluca Severi et al.   BREAST CANCER RESEARCH AND TREATMENT

Locally Disordered Methylation Forms the Basis of Intratumor Methylome Variation in Chronic Lymphocytic Leukemia

(2014) Dan A. Landau et al.   CANCER CELL

Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients

(2014) Scott M Langevin et al.   Epigenetics

Longitudinal epigenetic drift in mice perinatally exposed to lead

(2014) Christopher Faulk et al.   Epigenetics

Age-related epigenetic drift in the pathogenesis of MDS and AML

(2014) S. Maegawa et al.   GENOME RESEARCH

Aging and epigenetic drift: a vicious cycle

(2014) Jean-Pierre Issa   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic stochasticity, nuclear structure and cancer: the implications for medicine

(2014) A. P. Feinberg   JOURNAL OF INTERNAL MEDICINE

Modulation of Age- and Cancer-Associated DNA Methylation Change in the Healthy Colon by Aspirin and Lifestyle

(2014) Faiza Noreen et al.   JNCI-Journal of the National Cancer Institute

DNA methylation and body-mass index: a genome-wide analysis

(2014) Katherine J Dick et al.   LANCET

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Obesity accelerates epigenetic aging of human liver

(2014) S. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The meta-epigenomic structure of purified human stem cell populations is defined at cis-regulatory sequences

(2014) N. Ari Wijetunga et al.   Nature Communications

A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival

(2014) Shahzia Anjum et al.   Genome Medicine

The Dynamics of DNA Methylation Covariation Patterns in Carcinogenesis

(2014) Andrew E. Teschendorff et al.   PLoS Computational Biology

Aging of blood can be tracked by DNA methylation changes at just three CpG sites

(2014) Carola Weidner et al.   GENOME BIOLOGY

Genome-wide age-related DNA methylation changes in blood and other tissues relate to histone modification, expression and cancer

(2013) Z. Xu et al.   CARCINOGENESIS

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

(2013) Isabel Beerman et al.   Cell Stem Cell

DNA Methylation as a Long-term Biomarker of Exposure to Tobacco Smoke

(2013) Natalie S. Shenker et al.   EPIDEMIOLOGY

Large-scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization

(2013) K. D. Hansen et al.   GENOME RESEARCH

Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

(2013) A. E. Teschendorff et al.   HUMAN MOLECULAR GENETICS

Epigenome-wide Association Study of Breast Cancer Using Prospectively Collected Sister Study Samples

(2013) Zongli Xu et al.   JNCI-Journal of the National Cancer Institute

Charting a dynamic DNA methylation landscape of the human genome

(2013) Michael J. Ziller et al.   NATURE

Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation

(2013) Sonja Zeilinger et al.   PLoS One

Distinctive topology of age-associated epigenetic drift in the human interactome

(2013) J. West et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation

(2013) C. Tomasetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways

(2013) James West et al.   Scientific Reports

Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma

(2013) Matthias Lechner et al.   Genome Medicine

Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development

(2013) Allison Jones et al.   PLOS MEDICINE

Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape

(2013) Kenneth Day et al.   GENOME BIOLOGY

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance

(2013) David Martino et al.   GENOME BIOLOGY

DNA methylation arrays as surrogate measures of cell mixture distribution

(2012) Eugene Houseman et al.   BMC BIOINFORMATICS

Inflammation, DNA methylation and colitis-associated cancer

(2012) L. Hartnett et al.   CARCINOGENESIS

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

(2012) Thomas A. Rando et al.   CELL

A functional methylome map of ulcerative colitis

(2012) R. Hasler et al.   GENOME RESEARCH

Age-associated DNA methylation in pediatric populations

(2012) R. S. Alisch et al.   GENOME RESEARCH

Epigenetics makes its mark on women-specific cancers—an opportunity to redefine oncological approaches?

(2012) Martin Widschwendter et al.   GYNECOLOGIC ONCOLOGY

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues

(2012) Gilad Landan et al.   NATURE GENETICS

Estimating the human mutation rate using autozygosity in a founder population

(2012) Catarina D Campbell et al.   NATURE GENETICS

Detectable clonal mosaicism and its relationship to aging and cancer

(2012) Kevin B Jacobs et al.   NATURE GENETICS

Detectable clonal mosaicism from birth to old age and its relationship to cancer

(2012) Cathy C Laurie et al.   NATURE GENETICS

ChromHMM: automating chromatin-state discovery and characterization

(2012) Jason Ernst et al.   NATURE METHODS

Age-Associated Hyper-Methylated Regions in the Human Brain Overlap with Bivalent Chromatin Domains

(2012) Corey T. Watson et al.   PLoS One

Factors underlying variable DNA methylation in a human community cohort

(2012) L. L. Lam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct DNA methylomes of newborns and centenarians

(2012) H. Heyn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation

(2012) Andrew E Teschendorff et al.   Genome Medicine

DNA methylation studies using twins: what are they telling us?

(2012) Jordana T Bell et al.   GENOME BIOLOGY

Aging effects on DNA methylation modules in human brain and blood tissue

(2012) Steve Horvath et al.   GENOME BIOLOGY

The Impact of Recent Alcohol Use on Genome Wide DNA Methylation Signatures

(2012) Robert A. Philibert et al.   Frontiers in Genetics

Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging

(2011) M. T. Bocker et al.   BLOOD

CpG islands and the regulation of transcription

(2011) A. M. Deaton et al.   GENES & DEVELOPMENT

Telomeres and lifestyle factors: Roles in cellular aging

(2011) Jue Lin et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Increased methylation variation in epigenetic domains across cancer types

(2011) Kasper Daniel Hansen et al.   NATURE GENETICS

Epigenetic variation and cellular Darwinism

(2011) Jean-Pierre Issa   NATURE GENETICS

Epigenome-wide association studies for common human diseases

(2011) Vardhman K. Rakyan et al.   NATURE REVIEWS GENETICS

Epigenetic Predictor of Age

(2011) Sven Bocklandt et al.   PLoS One

Estimating human age from T-cell DNA rearrangements

(2010) D. Zubakov et al.   CURRENT BIOLOGY

Molecular pathology and age estimation

(2010) Christoph Meissner et al.   FORENSIC SCIENCE INTERNATIONAL

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer

(2010) A. E. Teschendorff et al.   GENOME RESEARCH

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

(2010) V. K. Rakyan et al.   GENOME RESEARCH

Widespread and tissue specific age-related DNA methylation changes in mice

(2010) S. Maegawa et al.   GENOME RESEARCH

Fine scale mapping of the breast cancer 16q12 locus

(2010) Miriam S. Udler et al.   HUMAN MOLECULAR GENETICS

Epigenetics as a unifying principle in the aetiology of complex traits and diseases

(2010) Arturas Petronis   NATURE

Taking the measure of the methylome

(2010) Stephan Beck   NATURE BIOTECHNOLOGY

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

(2010) I. Beerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Personalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index

(2010) A. P. Feinberg et al.   Science Translational Medicine

Aging and Chronic Sun Exposure Cause Distinct Epigenetic Changes in Human Skin

(2010) Elke Grönniger et al.   PLoS Genetics

DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells

(2009) Simone Bork et al.   AGING CELL

Meta-analysis of age-related gene expression profiles identifies common signatures of aging

(2009) João Pedro de Magalhães et al.   BIOINFORMATICS

The Role of Epigenetics in Aging and Autoimmunity

(2009) Annabelle Grolleau-Julius et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

An Epigenetic Signature in Peripheral Blood Predicts Active Ovarian Cancer

(2009) Andrew E. Teschendorff et al.   PLoS One

Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers

(2009) K. D. Siegmund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease

(2009) A. P. Feinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context

(2009) Brock C. Christensen et al.   PLoS Genetics

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer

(2008) H Suzuki et al.   BRITISH JOURNAL OF CANCER

Methylation of Polycomb Target Genes in Intestinal Cancer Is Mediated by Inflammation

(2008) M. A. Hahn et al.   CANCER RESEARCH

Telomeres and Aging

(2008) Geraldine Aubert et al.   PHYSIOLOGICAL REVIEWS

Persistent epigenetic differences associated with prenatal exposure to famine in humans

(2008) B. T. Heijmans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The methylome: approaches for global DNA methylation profiling

(2008) Stephan Beck et al.   TRENDS IN GENETICS