Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration

Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells

(2016) Unmesh Jadhav et al.   CELL

Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice

(2016) Peter Langfelder et al.   NATURE NEUROSCIENCE

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons

(2016) Ernest Palomer et al.   Nature Communications

Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry

(2015) S Marathe et al.   CELL DEATH AND DIFFERENTIATION

Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation

(2015) Marta Biagioli et al.   HUMAN MOLECULAR GENETICS

Coupling of T cell receptor specificity to natural killer T cell development by bivalent histone H3 methylation

(2015) Marc-Werner Dobenecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice

(2015) Josefa M. Sullivan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vitamin C Facilitates Dopamine Neuron Differentiation in Fetal Midbrain Through TET1- and JMJD3-Dependent Epigenetic Control Manner

(2015) Xi-Biao He et al.   STEM CELLS

Transcriptional Response of Polycomb Group Genes to Status Epilepticus in Mice is Modified by Prior Exposure to Epileptic Preconditioning

(2015) James P. Reynolds et al.   Frontiers in Neurology

RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression

(2015) Adam Labadorf et al.   PLoS One

The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington’s Disease

(2015) Xianjun Dong et al.   PLoS One

The roles and regulation of Polycomb complexes in neural development

(2014) Matthew Corley et al.   CELL AND TISSUE RESEARCH

Nascent RNA interaction keeps PRC2 activity poised and in check

(2014) Syuzo Kaneko et al.   GENES & DEVELOPMENT

An AUTS2–Polycomb complex activates gene expression in the CNS

(2014) Zhonghua Gao et al.   NATURE

G9a influences neuronal subtype specification in striatum

(2014) Ian Maze et al.   NATURE NEUROSCIENCE

Maintenance of postmitotic neuronal cell identity

(2014) Evan S Deneris et al.   NATURE NEUROSCIENCE

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease

(2014) X.-H. Lu et al.   Science Translational Medicine

MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis

(2014) Andrew G. Hoss et al.   PLoS Genetics

Dopamine Signaling Leads to Loss of Polycomb Repression and Aberrant Gene Activation in Experimental Parkinsonism

(2014) Erik Södersten et al.   PLoS Genetics

Synthetic CpG islands reveal DNA sequence determinants of chromatin structure

(2014) Elisabeth Wachter et al.   eLife

Network2Canvas: network visualization on a canvas with enrichment analysis

(2013) Christopher M. Tan et al.   BIOINFORMATICS

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

A double take on bivalent promoters

(2013) P. Voigt et al.   GENES & DEVELOPMENT

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia

(2013) Jiali Li et al.   NATURE NEUROSCIENCE

Targeting H3K4 trimethylation in Huntington disease

(2013) M. Vashishtha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-128 Governs Neuronal Excitability and Motor Behavior in Mice

(2013) C. L. Tan et al.   SCIENCE

oPOSSUM-3: Advanced Analysis of Regulatory Motif Over-Representation Across Genes or ChIP-Seq Datasets

(2013) Andrew T. Kwon et al.   G3-Genes Genomes Genetics

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Extremely Long-Lived Nuclear Pore Proteins in the Rat Brain

(2012) J. N. Savas et al.   SCIENCE

Regulation of Terminal Differentiation Programs in the Nervous System

(2011) Oliver Hobert   Annual Review of Cell and Developmental Biology

EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

(2011) E. Ezhkova et al.   GENES & DEVELOPMENT

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

(2010) Alexander Lachmann et al.   BIOINFORMATICS

Cell Type-Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward

(2010) M. K. Lobo et al.   SCIENCE

Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity

(2010) I. Maze et al.   SCIENCE

GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells

(2010) Eric M. Mendenhall et al.   PLoS Genetics

Huntingtin facilitates polycomb repressive complex 2

(2009) Ihn Sik Seong et al.   HUMAN MOLECULAR GENETICS

Revealing Global Regulatory Perturbations across Human Cancers

(2009) Hani Goodarzi et al.   MOLECULAR CELL

CREB regulation of nucleus accumbens excitability mediates social isolation–induced behavioral deficits

(2009) Deanna L Wallace et al.   NATURE NEUROSCIENCE

Control of Cognition and Adaptive Behavior by the GLP/G9a Epigenetic Suppressor Complex

(2009) Anne Schaefer et al.   NEURON

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types

(2008) Joseph P. Doyle et al.   CELL

A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types

(2008) Myriam Heiman et al.   CELL

DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates

(2008) Jennifer Illuzzi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

(2008) Fabio Mohn et al.   MOLECULAR CELL

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

(2008) Raphael Margueron et al.   MOLECULAR CELL

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

(2008) Manching Ku et al.   PLoS Genetics