Mechanoresponsive metabolism in cancer cell migration and metastasis

Mechanical regulation of glycolysis via cytoskeleton architecture

(2020) Jin Suk Park et al.   NATURE

Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing

(2020) Ryan T. Davis et al.   NATURE CELL BIOLOGY

Metastasis of cholangiocarcinoma is promoted by extended high-mannose glycans

(2020) Diane Dayoung Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion

(2020) R. Commander et al.   Nature Communications

Cancer cells with high-metastatic potential promote a glycolytic shift in activated fibroblasts

(2020) Akiko Kogure et al.   PLoS One

A metastasis map of human cancer cell lines

(2020) Xin Jin et al.   NATURE

Tunneling nanotubes, a novel mode of tumor cell-macrophage communication in tumor cell invasion

(2019) Samer J. Hanna et al.   JOURNAL OF CELL SCIENCE

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

(2019) Grant M. Fischer et al.   Cancer Discovery

Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization

(2019) Lisha Xiang et al.   Cell Death & Disease

Energetic regulation of coordinated leader–follower dynamics during collective invasion of breast cancer cells

(2019) Jian Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs

(2019) Laura C. Kelley et al.   DEVELOPMENTAL CELL

FDA Approval Summary: Ivosidenib for Relapsed or Refractory Acute Myeloid Leukemia with an Isocitrate Dehydrogenase-1 Mutation

(2019) Kelly J. Norsworthy et al.   CLINICAL CANCER RESEARCH

The extracellular matrix in tumor progression and metastasis

(2019) Johannes A. Eble et al.   CLINICAL & EXPERIMENTAL METASTASIS

Quantitative in vivo imaging of neuronal glucose concentrations with a genetically encoded fluorescence lifetime sensor

(2019) Carlos Manlio Díaz‐García et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer

(2019) Luigi Ippolito et al.   ONCOGENE

Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization

(2019) Harihar Basnet et al.   eLife

Hallmarks of Endothelial Cell Metabolism in Health and Disease

(2019) Xuri Li et al.   Cell Metabolism

Mechanisms and Implications of Metabolic Heterogeneity in Cancer

(2019) Jiyeon Kim et al.   Cell Metabolism

E-cadherin is required for metastasis in multiple models of breast cancer

(2019) Veena Padmanaban et al.   NATURE

Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress

(2019) Richard Burt et al.   BLOOD

On the energy efficiency of cell migration in diverse physical environments

(2019) Yizeng Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making

(2019) Matthew R. Zanotelli et al.   Nature Communications

Bioenergetics underlying single-cell migration on aligned nanofiber scaffolds

(2019) Abinash Padhi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization

(2018) Tanya Schild et al.   CANCER CELL

Mechanisms linking mechanotransduction and cell metabolism

(2018) Alicia M Salvi et al.   CURRENT OPINION IN CELL BIOLOGY

The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter

(2018) Kuan-Hsun Wu et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Regulation of ATP utilization during metastatic cell migration by collagen architecture

(2018) Matthew R. Zanotelli et al.   MOLECULAR BIOLOGY OF THE CELL

Energy Metabolism Drugs Block Triple Negative Breast Metastatic Cancer Cell Phenotype

(2018) Silvia Cecilia Pacheco-Velázquez et al.   MOLECULAR PHARMACEUTICS

Asparagine bioavailability governs metastasis in a model of breast cancer

(2018) Simon R. V. Knott et al.   NATURE

Cancer metabolism gets physical

(2018) Peter DelNero et al.   Science Translational Medicine

Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis

(2018) Maria Kalli et al.   Frontiers in Oncology

Enhancing the efficacy of glycolytic blockade in cancer cells via RAD51 inhibition

(2018) John J. Wilson et al.   CANCER BIOLOGY & THERAPY

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis

(2018) Marion Curtis et al.   Cell Metabolism

Anticancer Activity of Phloretin Against Human Gastric Cancer Cell Lines Involves Apoptosis, Cell Cycle Arrest, and Inhibition of Cell Invasion and JNK Signalling Pathway

(2018) Min Xu et al.   MEDICAL SCIENCE MONITOR

Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy

(2018) Thomas Bertero et al.   Cell Metabolism

Mannose impairs tumour growth and enhances chemotherapy

(2018) Pablo Sierra Gonzalez et al.   NATURE

Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments

(2018) Katrina M. Wisdom et al.   Nature Communications

Collagen density modulates triple-negative breast cancer cell metabolism through adhesion-mediated contractility

(2018) Emma J. Mah et al.   Scientific Reports

Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

(2017) Begum Erdogan et al.   JOURNAL OF CELL BIOLOGY

Cancer-associated fibroblasts lead tumor invasion through integrin-β3–dependent fibronectin assembly

(2017) Youmna Attieh et al.   JOURNAL OF CELL BIOLOGY

Force regulated conformational change of integrin α V β 3

(2017) Yunfeng Chen et al.   MATRIX BIOLOGY

Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration

(2017) Max-Hinderk Schuler et al.   MOLECULAR BIOLOGY OF THE CELL

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

(2017) Anna Labernadie et al.   NATURE CELL BIOLOGY

Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK

(2017) Jennifer L. Bays et al.   NATURE CELL BIOLOGY

Quantifying forces in cell biology

(2017) Pere Roca-Cusachs et al.   NATURE CELL BIOLOGY

Mechanoreciprocity in cell migration

(2017) Sjoerd van Helvert et al.   NATURE CELL BIOLOGY

FDA approves first CAR T therapy

(2017) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

(2017) Ilaria Elia et al.   Nature Communications

Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

(2017) Alexandros Glentis et al.   Nature Communications

Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy

(2017) Bin Li et al.   Oncotarget

The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand

(2017) Tamir Epstein et al.   PLoS One

Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy

(2016) R. Moschoi et al.   BLOOD

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

(2016) Hai Hu et al.   CELL

Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks

(2016) Peter Bieling et al.   CELL

Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth

(2016) Lifeng Yang et al.   Cell Metabolism

Impact of the physical microenvironment on tumor progression and metastasis

(2016) Fabian Spill et al.   CURRENT OPINION IN BIOTECHNOLOGY

AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion

(2016) Brian Cunniff et al.   MOLECULAR BIOLOGY OF THE CELL

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

(2016) Shawn M Davidson et al.   NATURE MEDICINE

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

The mechanical response of talin

(2016) Mingxi Yao et al.   Nature Communications

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

(2016) Edoardo Gaude et al.   Nature Communications

Elevation of β-galactoside α2,6-sialyltransferase 1 in a fructoseresponsive manner promotes pancreatic cancer metastasis

(2016) Chi-Che Hsieh et al.   Oncotarget

Assessment of elasticity of colorectal cancer tissue, clinical utility, pathological and phenotypical relevance

(2015) Shingo Kawano et al.   CANCER SCIENCE

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment

(2015) I. L. Romero et al.   CLINICAL CANCER RESEARCH

Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion

(2015) Hui-Hui Cao et al.   Molecular Cancer

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

(2015) Miranda Y. Fong et al.   NATURE CELL BIOLOGY

Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing

(2015) Mukund Gupta et al.   Nature Communications

The motility-proliferation-metabolism interplay during metastatic invasion

(2015) Inbal Hecht et al.   Scientific Reports

Leader cells regulate collective cell migration via Rac activation in the downstream signaling of integrin β1 and PI3K

(2015) Naoya Yamaguchi et al.   Scientific Reports

MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function

(2015) Andrés Caicedo et al.   Scientific Reports

Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells

(2015) Takumi Shiraishi et al.   Oncotarget

Mannose metabolism: More than meets the eye

(2014) Vandana Sharma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell jamming: Collective invasion of mesenchymal tumor cells imposed by tissue confinement

(2014) Anna Haeger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

(2014) Tomoyuki Mashimo et al.   CELL

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer

(2014) L. Yang et al.   Molecular Systems Biology

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Imaging Mitochondrial Flux in Single Cells with a FRET Sensor for Pyruvate

(2014) Alejandro San Martín et al.   PLoS One

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

Membrane Tension in Rapidly Moving Cells Is Determined by Cytoskeletal Forces

(2013) Arnon D. Lieber et al.   CURRENT BIOLOGY

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

(2013) Jennifer Pasquier et al.   Journal of Translational Medicine

Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner

(2013) M. Cerezo et al.   MOLECULAR CANCER THERAPEUTICS

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

A Genetically Encoded FRET Lactate Sensor and Its Use To Detect the Warburg Effect in Single Cancer Cells

(2013) Alejandro San Martín et al.   PLoS One

Minimization of thermodynamic costs in cancer cell invasion

(2013) L. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fructose consumption and cancer

(2013) Ava M. Port et al.   Current Opinion in Endocrinology Diabetes and Obesity

Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio

(2013) Mathew Tantama et al.   Nature Communications

High targeted migration of human mesenchymal stem cells grown in hypoxia is associated with enhanced activation of RhoA

(2013) Grigory Vertelov et al.   Stem Cell Research & Therapy

Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced β5-integrin expression in human gastric cancer SC-M1 cells

(2012) Wen-Yi Hung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Antitumor activity of the selective cyclooxygenase-2 inhibitor, celecoxib, on breast cancer in Vitro and in Vivo

(2012) Zhi-Jun Dai et al.   Cancer Cell International

Glucose transporters in cancer metabolism

(2012) Kehinde Adekola et al.   CURRENT OPINION IN ONCOLOGY

Myo1c facilitates G-actin transport to the leading edge of migrating endothelial cells

(2012) Yi Fan et al.   JOURNAL OF CELL BIOLOGY

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Actin-bundling proteins in cancer progression at a glance

(2012) R. P. Stevenson et al.   JOURNAL OF CELL SCIENCE

Redox regulation of cancer cell migration and invasion

(2012) Lalchhandami Tochhawng et al.   MITOCHONDRION

Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial–mesenchymal transition

(2012) KangAe Lee et al.   MOLECULAR BIOLOGY OF THE CELL

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metformin inhibits the development and metastasis of ovarian cancer

(2012) BUCHU WU et al.   ONCOLOGY REPORTS

Differential Expression of Metabolic Genes in Tumor and Stromal Components of Primary and Metastatic Loci in Pancreatic Adenocarcinoma

(2012) Nina V. Chaika et al.   PLoS One

Cellular Traction Stresses Increase with Increasing Metastatic Potential

(2012) Casey M. Kraning-Rush et al.   PLoS One

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Rho GTPases and their roles in cancer metabolism

(2012) Kristin F. Wilson et al.   TRENDS IN MOLECULAR MEDICINE

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3)

(2011) Kalimuthu Senthilkumar et al.   CELL BIOCHEMISTRY AND FUNCTION

Hypoxic regulation of mesenchymal stem cell migration: the role of RhoA and HIF-1α

(2011) Leah F. Raheja et al.   CELL BIOLOGY INTERNATIONAL

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Imaging Cytosolic NADH-NAD+ Redox State with a Genetically Encoded Fluorescent Biosensor

(2011) Yin Pun Hung et al.   Cell Metabolism

Glycolysis inhibition by 2-deoxy-d-glucose reverts the metastatic phenotype in vitro and in vivo

(2011) Joseph L. Sottnik et al.   CLINICAL & EXPERIMENTAL METASTASIS

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

Glutamine targeting inhibits systemic metastasis in the VM-M3 murine tumor model

(2010) Laura M. Shelton et al.   INTERNATIONAL JOURNAL OF CANCER

Fructose as a carbon source induces an aggressive phenotype in MDA-MB-468 breast tumor cells

(2010) Monzavi-Karbassi   INTERNATIONAL JOURNAL OF ONCOLOGY

Somatic mutations in mitochondrial genome and their potential roles in the progression of human gastric cancer

(2009) Wen-Yi Hung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

(2009) Ramon C. Sun et al.   BREAST CANCER RESEARCH AND TREATMENT

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

Physical forces during collective cell migration

(2009) Xavier Trepat et al.   Nature Physics

Regulation of the fructose transporter GLUT5 in health and disease

(2008) Veronique Douard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM