Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion

Energetic regulation of coordinated leader–follower dynamics during collective invasion of breast cancer cells

(2019) Jian Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Causes, consequences, and therapy of tumors acidosis

(2019) Smitha R. Pillai et al.   CANCER AND METASTASIS REVIEWS

Cancer stem cells (CSCs): metabolic strategies for their identification and eradication

(2018) Ernestina M. De Francesco et al.   BIOCHEMICAL JOURNAL

Metabolic reprogramming of mitochondrial respiration in metastatic cancer

(2018) P. M. Herst et al.   CANCER AND METASTASIS REVIEWS

Mitochondrial dynamics and metastasis

(2018) Dario C. Altieri   CELLULAR AND MOLECULAR LIFE SCIENCES

Infiltrative and drug‐resistant slow‐cycling cells support metabolic heterogeneity in glioblastoma

(2018) Lan B Hoang‐Minh et al.   EMBO JOURNAL

Tumour heterogeneity and metastasis at single-cell resolution

(2018) Devon A. Lawson et al.   NATURE CELL BIOLOGY

Metabolic cooperation between co-cultured lung cancer cells and lung fibroblasts

(2017) Michael I Koukourakis et al.   LABORATORY INVESTIGATION

Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration

(2017) Max-Hinderk Schuler et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming

(2017) Shujuan Sun et al.   Cell Death & Disease

Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

(2017) Chensu Wang et al.   Nature Communications

Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion

(2017) J. Konen et al.   Nature Communications

Intratumor Heterogeneity in Primary Kidney Cancer Revealed by Metabolic Profiling of Multiple Spatially Separated Samples within Tumors

(2017) Takatsugu Okegawa et al.   EBioMedicine

Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy

(2017) Seema Gupta et al.   Frontiers in Oncology

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876

(2016) Holger Siebeneicher et al.   ChemMedChem

Epigenetic regulation of the glucose transporter geneSlc2a1by β-hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice

(2016) Kosuke Tanegashima et al.   GENES TO CELLS

LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion

(2016) Jessica Konen et al.   MOLECULAR BIOLOGY OF THE CELL

AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion

(2016) Brian Cunniff et al.   MOLECULAR BIOLOGY OF THE CELL

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions

(2016) Inmaculada Martínez-Reyes et al.   MOLECULAR CELL

The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis

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A collective route to metastasis: Seeding by tumor cell clusters

(2016) K. J. Cheung et al.   SCIENCE

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

(2016) Edoardo Gaude et al.   Nature Communications

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism

(2015) X. Liu et al.   BLOOD

In SilicoModeling-based Identification of Glucose Transporter 4 (GLUT4)-selective Inhibitors for Cancer Therapy

(2015) Rama K. Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An epigenetically distinct breast cancer cell subpopulation promotes collective invasion

(2015) Jill M. Westcott et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion

(2015) Dayana B. Rivadeneira et al.   Science Signaling

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

(2015) Hilary A. Kenny et al.   Nature Communications

Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion

(2015) Dayana B. Rivadeneira et al.   Science Signaling

Metabolic Plasticity of Metastatic Breast Cancer Cells: Adaptation to Changes in the Microenvironment

(2015) Rui V. Simões et al.   NEOPLASIA

Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1α in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis

(2014) Atsushi Hamabe et al.   CANCER SCIENCE

Targeting the Metabolic Plasticity of Multiple Myeloma with FDA-Approved Ritonavir and Metformin

(2014) S. Dalva-Aydemir et al.   CLINICAL CANCER RESEARCH

The evolution of the unstable cancer genome

(2014) Rebecca A Burrell et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Intratumoral phenotypic heterogeneity as an encourager of cancer invasion

(2014) Yoojin Shin et al.   Integrative Biology

Tyr-301 Phosphorylation Inhibits Pyruvate Dehydrogenase by Blocking Substrate Binding and Promotes the Warburg Effect

(2014) Jun Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Oral Disinfectants Inhibit Protein-Protein Interactions Mediated by the Anti-Apoptotic Protein Bcl-xLand Induce Apoptosis in Human Oral Tumor Cells

(2013) Martin Gräber et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mitochondrial Localization and the Persistent Migration of Epithelial Cancer cells

(2013) Salil P. Desai et al.   BIOPHYSICAL JOURNAL

Leading malignant cells initiate collective epithelial cell invasion in a three-dimensional heterotypic tumor spheroid model

(2013) Shawn P. Carey et al.   CLINICAL & EXPERIMENTAL METASTASIS

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

Downregulation of the Mitochondrial Phosphatase PTPMT1 Is Sufficient to Promote Cancer Cell Death

(2013) Natalie M. Niemi et al.   PLoS One

Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration

(2012) Christine A. Caneba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intratumor Heterogeneity: Seeing the Wood for the Trees

(2012) T. A. Yap et al.   Science Translational Medicine

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker

(2011) Kátia C. Carvalho et al.   Clinics

Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo

(2011) Zuzana Zachar et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Dequalinium induces human leukemia cell death by affecting the redox balance

(2011) Ana I. García-Pérez et al.   LEUKEMIA RESEARCH

A Critical Role of Mitochondrial Phosphatase Ptpmt1 in Embryogenesis Reveals a Mitochondrial Metabolic Stress-Induced Differentiation Checkpoint in Embryonic Stem Cells

(2011) J. Shen et al.   MOLECULAR AND CELLULAR BIOLOGY

Abnormalities in Mitochondrial Structure in Cells from Patients with Bipolar Disorder

(2010) Anne M. Cataldo et al.   AMERICAN JOURNAL OF PATHOLOGY

Metabolomic Changes Accompanying Transformation and Acquisition of Metastatic Potential in a Syngeneic Mouse Mammary Tumor Model

(2010) Xin Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological Targeting of the Mitochondrial Phosphatase PTPMT1

(2010) D. Doughty-Shenton et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors

(2009) Robert H Kutner et al.   Nature Protocols