Structure and gating mechanism of the α7 nicotinic acetylcholine receptor

Mechanism of gating and partial agonist action in the glycine receptor

(2021) Jie Yu et al.   CELL

The M4 Helix Is Involved in α7 nACh Receptor Function

(2020) Ana R.G.M. da Costa Couto et al.   ACS Chemical Neuroscience

Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins

(2020) Md. Mahfuzur Rahman et al.   NEURON

Progress in nicotinic receptor structural biology

(2020) Anant Gharpure et al.   NEUROPHARMACOLOGY

Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs

(2020) Arvind Kumar et al.   Nature Communications

Cytokine Release Syndrome (CRS) and Nicotine in COVID-19 Patients: Trying to Calm the Storm

(2020) Jesus Gonzalez-Rubio et al.   Frontiers in Immunology

Shared structural mechanisms of general anaesthetics and benzodiazepines

(2020) Jeong Joo Kim et al.   NATURE

Improvement of cryo-EM maps by density modification

(2020) Thomas C. Terwilliger et al.   NATURE METHODS

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Mobility of Lower MA-Helices for Ion Conduction through Lateral Portals in 5-HT3A Receptors

(2020) Antonia G. Stuebler et al.   BIOPHYSICAL JOURNAL

Characterization of Residues in the 5-HT3 Receptor M4 Region That Contribute to Function

(2019) Susanne Mesoy et al.   ACS Chemical Neuroscience

Molecular dynamics simulations of dihydro‐β‐erythroidine bound to the human α4β2 nicotinic acetylcholine receptor

(2019) Rilei Yu et al.   BRITISH JOURNAL OF PHARMACOLOGY

CHAP: A Versatile Tool for the Structural and Functional Annotation of Ion Channel Pores

(2019) Gianni Klesse et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis for α-bungarotoxin insensitivity of neuronal nicotinic acetylcholine receptors

(2019) Steven M. Sine et al.   NEUROPHARMACOLOGY

α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins

(2019) G. Brent Dawe et al.   Nature Communications

Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor

(2019) Sandip Basak et al.   Nature Communications

Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor

(2019) Anant Gharpure et al.   NEURON

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Analysis of Global and Site-Specific Radiation Damage in Cryo-EM

(2018) Johan Hattne et al.   STRUCTURE

Cryo-EM structure of 5-HT3A receptor in its resting conformation

(2018) Sandip Basak et al.   Nature Communications

LY2087101 and dFBr share transmembrane binding sites in the (α4)3(β2)2 Nicotinic Acetylcholine Receptor

(2018) Farah Deba et al.   Scientific Reports

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Structural principles of distinct assemblies of the human α4β2 nicotinic receptor

(2018) Richard M. Walsh et al.   NATURE

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

(2018) Swastik Phulera et al.   eLife

Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor

(2018) Sandip Basak et al.   NATURE

Conformational transitions of the serotonin 5-HT3 receptor

(2018) Lucie Polovinkin et al.   NATURE

GABAA receptor signalling mechanisms revealed by structural pharmacology

(2018) Simonas Masiulis et al.   NATURE

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain

(2017) Jose A. Matta et al.   Cell Reports

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

X-ray structure of the human α4β2 nicotinic receptor

(2016) Claudio L. Morales-Perez et al.   NATURE

Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels

(2016) Ákos Nemecz et al.   NEURON

Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO

(2016) Shenyan Gu et al.   NEURON

Manipulation of Subunit Stoichiometry in Heteromeric Membrane Proteins

(2016) Claudio L. Morales-Perez et al.   STRUCTURE

Role of α7 nicotinic receptor in the immune system and intracellular signaling pathways

(2015) Robert Zdanowski et al.   Central European Journal of Immunology

Glycine receptor mechanism elucidated by electron cryo-microscopy

(2015) Juan Du et al.   NATURE

The coupling interface and pore domain codetermine the single-channel activity of the α7 nicotinic receptor

(2015) Hongxia Yan et al.   NEUROPHARMACOLOGY

Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor

(2015) Qinhui Zhang et al.   PLoS One

The Duplicated α7 Subunits Assemble and Form Functional Nicotinic Receptors with the Full-length α7

(2014) Ying Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of a human GABAA receptor

(2014) Paul S. Miller et al.   NATURE

X-ray structure of the mouse serotonin 5-HT3 receptor

(2014) Ghérici Hassaine et al.   NATURE

Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera

(2013) Sun Huang et al.   BIOCHEMICAL JOURNAL

Nicotinic Receptor Transduction Zone: Invariant Arginine Couples to Multiple Electron-Rich Residues

(2013) Nuriya Mukhtasimova et al.   BIOPHYSICAL JOURNAL

Determinants in the β and δ Subunit Cytoplasmic Loop Regulate Golgi Trafficking and Surface Expression of the Muscle Acetylcholine Receptor

(2013) Jolene Chang Rudell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

(2013) Xueming Li et al.   NATURE METHODS

A mutation in the extracellular domain of the α7 nAChR reduces calcium permeability

(2013) José O. Colón-Sáez et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Collaboration gets the most out of software

(2013) Andrew Morin et al.   eLife

Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors

(2012) Eugene Chun et al.   STRUCTURE

An extracellular RRR motif flanking the M1 transmembrane domain governs the biogenesis of homomeric neuronal nicotinic acetylcholine receptors

(2011) Daiane S. Alves et al.   FEBS LETTERS

Rings of Charge within the Extracellular Vestibule Influence Ion Permeation of the 5-HT3A Receptor

(2011) Matthew R. Livesey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Desensitization of α7 Nicotinic Receptor Is Governed by Coupling Strength Relative to Gate Tightness

(2011) Jianliang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Neuronal Nicotinic Acetylcholine Receptors, α4β4 and α7, Show Differential Agonist Binding Modes

(2011) Nyssa L. Puskar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-Channel and Structural Foundations of Neuronal  7 Acetylcholine Receptor Potentiation

(2011) C. J. B. daCosta et al.   JOURNAL OF NEUROSCIENCE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning

(2010) Rahul Srinivasan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Rapid desensitization of the rat α7 nAChR is facilitated by the presence of a proline residue in the outer β-sheet

(2010) Thomas J. McCormack et al.   JOURNAL OF PHYSIOLOGY-LONDON

Binding to Gating Transduction in Nicotinic Receptors: Cys-Loop Energetically Couples to Pre-M1 and M2-M3 Regions

(2009) W. Y. Lee et al.   JOURNAL OF NEUROSCIENCE

Nicotine binding to brain receptors requires a strong cation–π interaction

(2009) Xinan Xiu et al.   NATURE

A cog in cognition: How the α7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits

(2009) Steven C. Leiser et al.   PHARMACOLOGY & THERAPEUTICS

An Ion Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance

(2008) Scott B. Hansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Interface between Extracellular and Transmembrane Domains of Homomeric Cys-Loop Receptors Governs Open-Channel Lifetime and Rate of Desensitization

(2008) C. Bouzat et al.   JOURNAL OF NEUROSCIENCE

PROMALS3D: a tool for multiple protein sequence and structure alignments

(2008) Jimin Pei et al.   NUCLEIC ACIDS RESEARCH

Potentiation of  7 nicotinic acetylcholine receptors via an allosteric transmembrane site

(2008) G. T. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aromatic residues at position 55 of rat α7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization

(2007) Elaine A. Gay et al.   JOURNAL OF PHYSIOLOGY-LONDON