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Title
Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics
Authors
Keywords
Pyruvate kinase M2, Long noncoding RNA, Tumor microenvironment, Inhibitors, Agonists
Journal
CANCER LETTERS
Volume 503, Issue -, Pages 240-248
Publisher
Elsevier BV
Online
2020-11-24
DOI
10.1016/j.canlet.2020.11.018
References
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Note: Only part of the references are listed.- PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission
- (2020) Jiachao Guo et al. Aging-US
- Cancer Liquid Biopsy Using Integrated Microfluidic Exosome Analysis Platforms
- (2020) Guiying Li et al. Biotechnology Journal
- Cancer statistics, 2020
- (2020) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- MiR-181b suppress glioblastoma multiforme growth through inhibition of SP1-mediated glucose metabolism
- (2020) JianXing Yin et al. Cancer Cell International
- PKM2 regulates angiogenesis of VR‐EPCs through modulating glycolysis, mitochondrial fission, and fusion
- (2020) Ranyue Ren et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo
- (2020) Yahui Ding et al. JOURNAL OF MEDICINAL CHEMISTRY
- Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3
- (2020) Rizhen Huang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Effects of Shikonin on the Functions of Myeloid Dendritic Cells in a Mouse Model of Severe Aplastic Anemia
- (2020) Mengying Zheng et al. MEDIATORS OF INFLAMMATION
- Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA
- (2020) Pan Wu et al. Molecular Cancer
- Long non‑coding RNA BCYRN1 promotes glycolysis and tumor progression by regulating the miR‑149/PKM2 axis in non‑small‑cell lung cancer
- (2020) Ning Lang et al. Molecular Medicine Reports
- Nur77-activated lncRNA WFDC21P attenuates hepatocarcinogenesis via modulating glycolysis
- (2020) Yun-feng Guan et al. ONCOGENE
- FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication
- (2020) Hsin-Jung Wu et al. ONCOGENE
- Effect of 3-O-acetylaleuritolic acid from in vitro-cultured Drosera spatulata on cancer cells survival and migration
- (2020) Ewa Toton et al. Pharmacological Reports
- Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis
- (2020) Thomas J. Wubben et al. Scientific Reports
- Long noncoding RNA HULC accelerates the growth of human liver cancer stem cells by upregulating CyclinD1 through miR675-PKM2 pathway via autophagy
- (2020) Chen Wang et al. Stem Cell Research & Therapy
- Extracellular vesicle packaged LMP1-activated fibroblasts promote tumor progression via autophagy and stroma-tumor metabolism coupling
- (2020) Xia Wu et al. CANCER LETTERS
- The role of exosomes in metastasis and progression of melanoma
- (2020) Raghavendra Gowda et al. CANCER TREATMENT REVIEWS
- Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment
- (2020) Pei-pei Hou et al. MOLECULAR CELL
- PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation
- (2020) Luis Eduardo Alves Damasceno et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Melittin ameliorates inflammation in mouse acute liver failure via inhibition of PKM2-mediated Warburg effect
- (2020) Xue-gong Fan et al. ACTA PHARMACOLOGICA SINICA
- Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH
- (2020) Fang Xu et al. Redox Biology
- PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation
- (2019) Tong Li et al. Protein & Cell
- Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma
- (2019) Hao Yang et al. ONCOGENE
- The prognostic value of PKM2 and its correlation with tumour cell PD-L1 in lung adenocarcinoma
- (2019) Chang-Ying Guo et al. BMC CANCER
- Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells
- (2019) Yanzhu Lin et al. Cancer Cell International
- Exosomes from activated hepatic stellate cells contain GLUT1 and PKM2: a role for exosomes in metabolic switch of liver nonparenchymal cells
- (2019) Lu Wan et al. FASEB JOURNAL
- SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species
- (2019) Weiping Yu et al. OncoTargets and Therapy
- Programmed Cell Death Ligand-1 (PD-L1) and CD8 Expression Profiling Identify an Immunologic Subtype of Pancreatic Ductal Adenocarcinomas with Favorable Survival
- (2019) Ludmila Danilova et al. Cancer Immunology Research
- Arsenic trioxide inhibits EMT in hepatocellular carcinoma by promoting lncRNA MEG3 via PKM2
- (2019) Zhuoyang Fan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Subcellular compartmentalization of PKM2 identifies anti-PKM2 therapy response in vitro and in vivo mouse model of human non-small-cell lung cancer
- (2019) Akiko Suzuki et al. PLoS One
- LncRNA LINC00689 promotes the growth, metastasis and glycolysis of glioma cells by targeting miR-338-3p/PKM2 axis
- (2019) Xin Liu et al. BIOMEDICINE & PHARMACOTHERAPY
- Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis
- (2019) Jinlu Dai et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Role of the dynamic tumor microenvironment in controversies regarding immune checkpoint inhibitors for the treatment of non-small cell lung cancer (NSCLC) with EGFR mutations
- (2019) Anqi Lin et al. Molecular Cancer
- Pharmacological properties and derivatives of shikonin—A review in recent years
- (2019) Chuanjie Guo et al. PHARMACOLOGICAL RESEARCH
- Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer
- (2019) Goran Hamid Mohammad et al. Cancers
- Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-neuroinflammatory Agents for Ischemic Stroke
- (2019) Xu-Wen Li et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity
- (2019) Stefano Angiari et al. Cell Metabolism
- Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer
- (2019) Sehui Kim et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Long non-coding RNA LINC00504 regulates the Warburg effect in ovarian cancer through inhibition of miR-1244
- (2019) Ya Liu et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Synthesis of Amino Acid–Naphthoquinones and In Vitro Studies on Cervical and Breast Cell Lines
- (2019) Ernesto Rivera-Ávalos et al. MOLECULES
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- (2019) Robert D. Leone et al. SCIENCE
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- (2019) Savvas Petanidis et al. BIOMEDICINE & PHARMACOTHERAPY
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- (2019) Valentina Pucino et al. Cell Metabolism
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- (2018) Ashley A. Untereiner et al. BIOCHEMICAL PHARMACOLOGY
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- (2018) Zehua Bian et al. CLINICAL CANCER RESEARCH
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- (2018) Shuo Chen et al. International Journal of Biological Sciences
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- (2018) Ming-Chuan Hsu et al. Molecular Cancer
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- (2018) Qidi Zheng et al. Cell Death & Disease
- LncRNA XLOC_006390 facilitates cervical cancer tumorigenesis and metastasis as a ceRNA against miR-331-3p and miR-338-3p
- (2018) Xiaotian Luan et al. Journal of Gynecologic Oncology
- Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells
- (2018) Oliver A. Stone et al. Nature Communications
- LncRNA MAFG-AS1 promotes the progression of colorectal cancer by sponging miR-147b and activation of NDUFA4
- (2018) Shanshan Cui et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase
- (2017) Xianling Ning et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- LncRNA-TP53TG1 Participated in the Stress Response Under Glucose Deprivation in Glioma
- (2017) Xin Chen et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Synthesis and antitumor activity of novel 2, 3-didithiocarbamate substituted naphthoquinones as inhibitors of pyruvate kinase M2 isoform
- (2017) Xianling Ning et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2
- (2017) Wei Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Corrigendum: Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
- (2017) Weiwei Yang et al. NATURE
- The functions and unique features of long intergenic non-coding RNA
- (2017) Julia D. Ransohoff et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H 2 S Levels: H 2 S Donors and H 2 S Biosynthesis Inhibitors
- (2017) Csaba Szabo et al. PHARMACOLOGICAL REVIEWS
- Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23
- (2017) Yao Wei et al. Nature Communications
- Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors
- (2017) Eva M. Palsson-McDermott et al. Frontiers in Immunology
- Linc-ROR confers gemcitabine resistance to pancreatic cancer cells via inducing autophagy and modulating the miR-124/PTBP1/PKM2 axis
- (2016) Chenggang Li et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- PKM2, cancer metabolism, and the road ahead
- (2016) Talya L Dayton et al. EMBO REPORTS
- Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma
- (2016) Talya L. Dayton et al. GENES & DEVELOPMENT
- Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis
- (2016) Jun Wei et al. NATURE IMMUNOLOGY
- Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer
- (2016) Nadiya Druzhyna et al. PHARMACOLOGICAL RESEARCH
- Brain aerobic glycolysis and motor adaptation learning
- (2016) Benjamin J. Shannon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation
- (2015) Sophia Y. Lunt et al. MOLECULAR CELL
- PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2
- (2015) Timothy H. Witney et al. Science Translational Medicine
- miR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer
- (2015) Haiyan Li et al. Oncotarget
- Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread
- (2015) Elisa Giannoni et al. Oncotarget
- Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis
- (2015) Katharina Bluemlein et al. Oncotarget
- Activators of PKM2 in cancer metabolism
- (2014) Steven L Warner et al. Future Medicinal Chemistry
- SAICAR Induces Protein Kinase Activity of PKM2 that Is Necessary for Sustained Proliferative Signaling of Cancer Cells
- (2014) Kirstie E. Keller et al. MOLECULAR CELL
- Simultaneous Expression of Cancer Stem Cell-Like Properties and Cancer-Associated Fibroblast-Like Properties in a Primary Culture of Breast Cancer Cells
- (2014) Mami Ishikawa et al. Cancers
- PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells
- (2013) William J. Israelsen et al. CELL
- PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells
- (2013) Yuhui Jiang et al. MOLECULAR CELL
- Allosteric Regulation of PKM2 Allows Cellular Adaptation to Different Physiological States
- (2013) D. Y. Gui et al. Science Signaling
- HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1-3 and PKM2
- (2013) Alessandro Prigione et al. STEM CELLS
- PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis
- (2012) Weiwei Yang et al. CELL
- Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase
- (2012) Xueliang Gao et al. MOLECULAR CELL
- Serine is a natural ligand and allosteric activator of pyruvate kinase M2
- (2012) Barbara Chaneton et al. NATURE
- Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
- (2012) Dimitrios Anastasiou et al. Nature Chemical Biology
- Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
- (2012) J. Ye et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
- (2011) Weibo Luo et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells
- (2010) Sybille Mazurek INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
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