Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting β-catenin by activating PKM2 and inactivating PTEN

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway

(2017) Xiao-yu Li et al.   Molecular Therapy-Nucleic Acids

Tanshinone ⅡA inhibits human esophageal cancer cell growth through miR-122-mediated PKM2 down-regulation

(2016) Hong-Sheng Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Fenofibrate inhibited pancreatic cancer cells proliferation via activation of p53 mediated by upregulation of LncRNA MEG3

(2016) Duanmin Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN-PI3K-AKT-mTOR signaling axis

(2016) Weiguo Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases

(2016) Zan Chen et al.   BIOCHEMISTRY

LncRNA-MEG3 inhibits cell proliferation of endometrial carcinoma by repressing Notch signaling

(2016) Qingyun Guo et al.   BIOMEDICINE & PHARMACOTHERAPY

Parthenolide induces apoptosis and autophagy through the suppression of PI3K/Akt signaling pathway in cervical cancer

(2016) Sridharan Jeyamohan et al.   BIOTECHNOLOGY LETTERS

AIMP2 Controls Intestinal Stem Cell Compartments and Tumorigenesis by Modulating Wnt/ -Catenin Signaling

(2016) M. K. Yum et al.   CANCER RESEARCH

SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth

(2016) Seong-Hoon Park et al.   CANCER RESEARCH

miR‐10b expression in breast cancer stem cells supports self‐renewal through negative PTEN regulation and sustained AKT activation

(2016) Ivan Bahena‐Ocampo et al.   EMBO REPORTS

Regulation of the imprintedDlk1-Dio3locus by allele-specific enhancer activity

(2016) Zhuojuan Luo et al.   GENES & DEVELOPMENT

The liver-specific microRNA-122*, the complementary strand of microRNA-122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitry

(2016) Alina Simerzin et al.   HEPATOLOGY

MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription

(2016) Yue Li et al.   HEPATOLOGY

FAK Promotes Osteoblast Progenitor Cell Proliferation and Differentiation by Enhancing Wnt Signaling

(2016) Chunhui Sun et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model

(2016) Oh-Joon Kwon et al.   JOURNAL OF CLINICAL INVESTIGATION

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

(2016) Ninel Azoitei et al.   Molecular Cancer

MSK1-Mediated β-Catenin Phosphorylation Confers Resistance to PI3K/mTOR Inhibitors in Glioblastoma

(2016) Shaofang Wu et al.   MOLECULAR CANCER THERAPEUTICS

MicroRNA-29b inhibits TGF-β1-induced fibrosis via regulation of the TGF-β1/Smad pathway in primary human endometrial stromal cells

(2016) JINGXIONG LI et al.   Molecular Medicine Reports

PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

(2016) Seyedmehdi Shojaee et al.   NATURE MEDICINE

PTEN enables the development of pre-B acute lymphoblastic leukemia

(2016) Jérôme Fortin et al.   NATURE MEDICINE

RNA interference–induced hepatotoxicity results from loss of the first synthesized isoform of microRNA-122 in mice

(2016) Paul N Valdmanis et al.   NATURE MEDICINE

lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal

(2016) Pingping Zhu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Gastrin promotes the metastasis of gastric carcinoma through the β-catenin/TCF-4 pathway

(2016) Kun Zhuang et al.   ONCOLOGY REPORTS

Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas

(2016) Saya H. Ebbesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PKM2 and cancer: The function of PKM2 beyond glycolysis

(2016) GAOCHAO DONG et al.   Oncology Letters

lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal

(2016) Pingping Zhu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells

(2016) Camila S. Matsumoto et al.   Oncotarget

Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1α activation

(2016) Aditya Ambade et al.   Scientific Reports

Effect of Mir-122 on Human Cholangiocarcinoma Proliferation, Invasion, and Apoptosis Through P53 Expression

(2016) Cuiping Wu et al.   MEDICAL SCIENCE MONITOR

PTEN negatively regulates mTORC2 formation and signaling in grade IV glioma via Rictor hyperphosphorylation at Thr1135 and direct the mode of action of an mTORC1/2 inhibitor

(2016) K Bhattacharya et al.   Oncogenesis

Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines

(2016) Shaina N. Porter et al.   Stem Cell Reports

Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner

(2016) Jia Liu et al.   Cell Discovery

MiR-122 Reverses the Doxorubicin-Resistance in Hepatocellular Carcinoma Cells through Regulating the Tumor Metabolism

(2016) Chenwei Pan et al.   PLoS One

A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion

(2016) Tsuneo Ikenoue et al.   Scientific Reports

Long noncoding RNA MEG3 is downregulated in cervical cancer and affects cell proliferation and apoptosis by regulating miR-21

(2015) Jun Zhang et al.   CANCER BIOLOGY & THERAPY

Hepatitis C Virus RNA Functionally Sequesters miR-122

(2015) Joseph M. Luna et al.   CELL

Long Non-Coding RNA MEG3 Inhibits Cell Proliferation and Induces Apoptosis in Prostate Cancer

(2015) Gang Luo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

FOXKs Promote Wnt/β-Catenin Signaling by Translocating DVL into the Nucleus

(2015) Wenqi Wang et al.   DEVELOPMENTAL CELL

β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis

(2015) Satdarshan Pal Monga   GASTROENTEROLOGY

The mechanism of adenosine-mediated activation of lncRNA MEG3 and its antitumor effects in human hepatoma cells

(2015) LI-XUAN LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Epigenetic repression of long non-coding RNA MEG3 mediated by DNMT1 represses the p53 pathway in gliomas

(2015) JIA LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression

(2015) Weizhao Peng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Lack of Evidence for PKM2 Protein Kinase Activity

(2015) Aaron M. Hosios et al.   MOLECULAR CELL

Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90–EGFR association

(2015) Y-C Yang et al.   ONCOGENE

ECM1 regulates tumor metastasis and CSC-like property through stabilization of β-catenin

(2015) K-m Lee et al.   ONCOGENE

Long Noncoding RNA MEG3 Interacts with p53 Protein and Regulates Partial p53 Target Genes in Hepatoma Cells

(2015) Juanjuan Zhu et al.   PLoS One

Upregulation of lncRNA MEG3 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells From Multiple Myeloma Patients By Targeting BMP4 Transcription

(2015) Wenzhuo Zhuang et al.   STEM CELLS

Decreased expression of MEG3 contributes to retinoblastoma progression and affects retinoblastoma cell growth by regulating the activity of Wnt/β-catenin pathway

(2015) Yali Gao et al.   TUMOR BIOLOGY

PKM2 promotes stemness of breast cancer cell by through Wnt/β-catenin pathway

(2015) Zheng Zhao et al.   TUMOR BIOLOGY

Inhibitory effect of 2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo(b)pyran (K-1) on human primary endometrial hyperplasial cells mediated via combined suppression of Wnt/β-catenin signaling and PI3K/Akt survival pathway

(2014) V Chandra et al.   Cell Death & Disease

Control of glioma cell death and differentiation by PKM2–Oct4 interaction

(2014) M Morfouace et al.   Cell Death & Disease