Subcellular compartmentalization of PKM2 identifies anti-PKM2 therapy response in vitro and in vivo mouse model of human non-small-cell lung cancer

Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress

(2018) Yi-Chieh Yang et al.   CANCER LETTERS

PKM2, a potential target for regulating cancer

(2018) Yu-huan Li et al.   GENE

A Novel Role for Pyruvate Kinase M2 as a Corepressor for P53 during the DNA Damage Response in Human Tumor Cells

(2016) Li Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

(2016) Ninel Azoitei et al.   Molecular Cancer

Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein

(2016) Juliana F. Ortega et al.   Oncotarget

Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis

(2016) Haiping Zhou et al.   Oncotarget

Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer

(2016) Wei Lu et al.   Scientific Reports

Targeting of IL-4 and IL-13 receptors for cancer therapy

(2015) Akiko Suzuki et al.   CYTOKINE

Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90–EGFR association

(2015) Y-C Yang et al.   ONCOGENE

PKM2 Subcellular Localization Is Involved in Oxaliplatin Resistance Acquisition in HT29 Human Colorectal Cancer Cell Lines

(2015) Alba Ginés et al.   PLoS One

Nuclear PKM2 contributes to gefitinib resistance via upregulation of STAT3 activation in colorectal cancer

(2015) Qiong Li et al.   Scientific Reports

Pyruvate kinase M2 and cancer: an updated assessment

(2014) Mohd Askandar Iqbal et al.   FEBS LETTERS

SAICAR Induces Protein Kinase Activity of PKM2 that Is Necessary for Sustained Proliferative Signaling of Cancer Cells

(2014) Kirstie E. Keller et al.   MOLECULAR CELL

Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition

(2014) A. Hamabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-4 receptor alpha overexpression in human bladder cancer correlates with the pathological grade and stage of the disease

(2014) Bharat H. Joshi et al.   Cancer Medicine

The Warburg effect then and now: From cancer to inflammatory diseases

(2013) Eva M. Palsson-McDermott et al.   BIOESSAYS

PKM2 and ACVR 1C are prognostic markers for poor prognosis of gallbladder cancer

(2013) J. Li et al.   Clinical & Translational Oncology

PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells

(2013) Yuhui Jiang et al.   MOLECULAR CELL

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

(2012) Michael S. Goldberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis

(2012) Weiwei Yang et al.   MOLECULAR CELL

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth

(2012) M. Cortes-Cros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of the M2 isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancer

(2012) Jae Yun Lim   WORLD JOURNAL OF GASTROENTEROLOGY

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice

(2010) Hua-shan Shi et al.   CANCER SCIENCE

Identification of small molecule inhibitors of pyruvate kinase M2

(2009) Matthew G. Vander Heiden et al.   BIOCHEMICAL PHARMACOLOGY

Evaluation of SubstitutedN,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

(2009) Matthew B. Boxer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Human Adrenomedullin Up-regulates Interleukin-13 Receptor  2 Chain in Prostate Cancer In vitro and In vivo: A Novel Approach to Sensitize Prostate Cancer to Anticancer Therapy

(2008) B. H. Joshi et al.   CANCER RESEARCH

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE