Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling
Authors
Keywords
-
Journal
Molecular Cancer
Volume 17, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-02-15
DOI
10.1186/s12943-018-0791-3
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase
- (2017) Xianling Ning et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer
- (2017) Tai-Kuang Chao et al. PLoS One
- PKM2 promotes cell migration and inhibits autophagy by mediating PI3K/AKT activation and contributes to the malignant development of gastric cancer
- (2017) Chao Wang et al. Scientific Reports
- Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2
- (2016) Ji Liang et al. CELL RESEARCH
- PKM2, cancer metabolism, and the road ahead
- (2016) Talya L Dayton et al. EMBO REPORTS
- Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma
- (2016) Talya L. Dayton et al. GENES & DEVELOPMENT
- PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells
- (2016) Joydeep Mukherjee et al. INTERNATIONAL JOURNAL OF CANCER
- PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation
- (2016) Ninel Azoitei et al. Molecular Cancer
- Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome
- (2016) Goran Hamid Mohammad et al. PLoS One
- Overexpression of pyruvate kinase M2 predicts a poor prognosis for patients with osteosarcoma
- (2016) Zheng-xuan Liu et al. TUMOR BIOLOGY
- PKM2 released by neutrophils at wound site facilitates early wound healing by promoting angiogenesis
- (2016) Yinwei Zhang et al. WOUND REPAIR AND REGENERATION
- Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies
- (2016) Jiayuan Wu et al. OncoTargets and Therapy
- PKM2 and cancer: The function of PKM2 beyond glycolysis
- (2016) GAOCHAO DONG et al. Oncology Letters
- Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer
- (2016) Wei Lu et al. Scientific Reports
- PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2
- (2016) Nan Li et al. Cell Reports
- Interaction with Pyruvate Kinase M2 Destabilizes Tristetraprolin by Proteasome Degradation and Regulates Cell Proliferation in Breast Cancer
- (2016) Liangqian Huang et al. Scientific Reports
- Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells
- (2015) Peng Yang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Overexpression of pyruvate kinase M2 associates with aggressive clinicopathological features and unfavorable prognosis in oral squamous cell carcinoma
- (2015) Yanling Wang et al. CANCER BIOLOGY & THERAPY
- Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages
- (2015) Eva M. Palsson-McDermott et al. Cell Metabolism
- Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells
- (2015) Dong Joon Kim et al. EXPERIMENTAL CELL RESEARCH
- PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma
- (2015) Guanzhen Yu et al. Molecular Cancer
- Lack of Evidence for PKM2 Protein Kinase Activity
- (2015) Aaron M. Hosios et al. MOLECULAR CELL
- Pyruvate kinase: Function, regulation and role in cancer
- (2015) William J. Israelsen et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Blood-Based Protein Biomarker Panel for the Detection of Colorectal Cancer
- (2015) Kim Y. C. Fung et al. PLoS One
- Nuclear PKM2 contributes to gefitinib resistance via upregulation of STAT3 activation in colorectal cancer
- (2015) Qiong Li et al. Scientific Reports
- Pyruvate kinase M2 and cancer: an updated assessment
- (2014) Mohd Askandar Iqbal et al. FEBS LETTERS
- Overexpression of metabolic markers PKM2 and LDH5 correlates with aggressive clinicopathological features and adverse patient prognosis in tongue cancer
- (2014) Chunping Yuan et al. HISTOPATHOLOGY
- Pyruvate Kinase M2 in Blood Circulation Facilitates Tumor Growth by Promoting Angiogenesis
- (2014) Liangwei Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression patterns of three regulation enzymes in glycolysis in esophageal squamous cell carcinoma: association with survival
- (2014) Wenfeng Li et al. MEDICAL ONCOLOGY
- SAICAR Induces Protein Kinase Activity of PKM2 that Is Necessary for Sustained Proliferative Signaling of Cancer Cells
- (2014) Kirstie E. Keller et al. MOLECULAR CELL
- Control of glioma cell death and differentiation by PKM2–Oct4 interaction
- (2014) M Morfouace et al. Cell Death & Disease
- PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells
- (2014) Yuhui Jiang et al. Nature Communications
- PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells
- (2013) William J. Israelsen et al. CELL
- PKM2 and ACVR 1C are prognostic markers for poor prognosis of gallbladder cancer
- (2013) J. Li et al. Clinical & Translational Oncology
- Extracellular vesicles: Exosomes, microvesicles, and friends
- (2013) Graça Raposo et al. JOURNAL OF CELL BIOLOGY
- High expression of glycolytic and pigment proteins is associated with worse clinical outcome in stage III melanoma
- (2013) Johan Falkenius et al. MELANOMA RESEARCH
- PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells
- (2013) Yuhui Jiang et al. MOLECULAR CELL
- Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells
- (2012) M. Tamada et al. CANCER RESEARCH
- Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase
- (2012) Xueliang Gao et al. MOLECULAR CELL
- Serine is a natural ligand and allosteric activator of pyruvate kinase M2
- (2012) Barbara Chaneton et al. NATURE
- Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
- (2012) Dimitrios Anastasiou et al. Nature Chemical Biology
- SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions
- (2012) K. E. Keller et al. SCIENCE
- Overexpression of the M2 isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancer
- (2012) Jae Yun Lim WORLD JOURNAL OF GASTROENTEROLOGY
- Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
- (2011) Weiwei Yang et al. NATURE
- Comparative Proteomic Approach Identifies Pkm2 and Cofilin-1 as Potential Diagnostic, Prognostic and Therapeutic Targets for Pulmonary Adenocarcinoma
- (2011) Xing-chen Peng et al. PLoS One
- Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review
- (2011) Paolo E. Porporato et al. Frontiers in Pharmacology
- Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase
- (2010) Jian-kang Jiang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
- (2010) Sonja I Buschow et al. IMMUNOLOGY AND CELL BIOLOGY
- Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells
- (2010) Sybille Mazurek INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Exosomes: Extracellular organelles important in intercellular communication
- (2010) Suresh Mathivanan et al. Journal of Proteomics
- Differential proteomic profiling of chordomas and analysis of prognostic factors
- (2010) Hua Zhou et al. JOURNAL OF SURGICAL ONCOLOGY
- Identification of small molecule inhibitors of pyruvate kinase M2
- (2009) Matthew G. Vander Heiden et al. BIOCHEMICAL PHARMACOLOGY
- Evaluation of SubstitutedN,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase
- (2009) Matthew B. Boxer et al. JOURNAL OF MEDICINAL CHEMISTRY
- Four-Gene Expression Ratio Test for Survival in Patients Undergoing Surgery for Mesothelioma
- (2009) G. J. Gordon et al. JNCI-Journal of the National Cancer Institute
- HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
- (2009) Charles J. David et al. NATURE
- ExoCarta: A compendium of exosomal proteins and RNA
- (2009) Suresh Mathivanan et al. PROTEOMICS
- Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
- (2009) T. Hitosugi et al. Science Signaling
- Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation
- (2008) Gilles A. Spoden et al. INTERNATIONAL JOURNAL OF CANCER
- Pyruvate kinase M2 is a phosphotyrosine-binding protein
- (2008) Heather R. Christofk et al. NATURE
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
- (2008) Heather R. Christofk et al. NATURE
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started