Curcumin: A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes

Insights into the Effect of Curcumin and (–)-Epigallocatechin-3-Gallate on the Aggregation of Aβ(1–40) Monomers by Means of Molecular Dynamics

(2020) Francesco Tavanti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin Inhibits the Primary Nucleation of Amyloid-Beta Peptide: A Molecular Dynamics Study

(2020) Irini Doytchinova et al.   Biomolecules

Benefits of curcumin in brain disorders

(2019) Abid Bhat et al.   BIOFACTORS

Causative Links between Protein Aggregation and Oxidative Stress: A Review

(2019) Elise Lévy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interactions between Curcumin Derivatives and Amyloid-β Fibrils: Insights from Molecular Dynamics Simulations

(2019) Joseph M. Jakubowski et al.   Journal of Chemical Information and Modeling

Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial

(2018) Gary W. Small et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies

(2018) Shreyasi Asthana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

One molecule, many targets and numerous effects: the pleiotropy of curcumin lies in its chemical structure

(2018) Mahdi Hatamipour et al.   CURRENT PHARMACEUTICAL DESIGN

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

(2018) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

Curcuminoid Binds to Amyloid-β1-42 Oligomer and Fibril

(2018) Daijiro Yanagisawa et al.   JOURNAL OF ALZHEIMERS DISEASE

Curcumin Inhibits Tau Aggregation and Disintegrates Preformed Tau Filaments in vitro

(2017) Jitendra Subhash Rane et al.   JOURNAL OF ALZHEIMERS DISEASE

PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8

(2017) Michiaki Okuda et al.   JOURNAL OF ALZHEIMERS DISEASE

Curcumin as a potential candidate for treating hyperlipidemia: A review of cellular and metabolic mechanisms

(2017) Yunes Panahi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Endoplasmic reticulum stress and inflammation in the central nervous system

(2017) Neil T. Sprenkle et al.   Molecular Neurodegeneration

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease

(2017) Gargi Ganguly et al.   Drug Design Development and Therapy

Nanoformulations of curcumin: an emerging paradigm for improved remedial application

(2017) Meeta Gera et al.   Oncotarget

Protein aggregation into insoluble deposits protects from oxidative stress

(2017) Anita Carija et al.   Redox Biology

Curcumin as a multifaceted compound against human papilloma virus infection and cervical cancers: A review of chemistry, cellular, molecular, and preclinical features

(2016) Manouchehr Teymouri et al.   BIOFACTORS

Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults

(2016) Stephanie R. Rainey-Smith et al.   BRITISH JOURNAL OF NUTRITION

Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes

(2016) Amit S. Pithadia et al.   CHEMICAL COMMUNICATIONS

A comparative study of dietary curcumin, nanocurcumin, and other classical amyloid-binding dyes for labeling and imaging of amyloid plaques in brain tissue of 5×-familial Alzheimer’s disease mice

(2016) Panchanan Maiti et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Protective effects of a natural product, curcumin, against amyloid β induced mitochondrial and synaptic toxicities in Alzheimer's disease

(2016) P Hemachandra Reddy et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases

(2016) Amir Abbas Momtazi et al.   Molecular Diagnosis & Therapy

Multifunctionality of self-assembled nanogels of curcumin-hyaluronic acid conjugates on inhibiting amyloid β-protein fibrillation and cytotoxicity

(2016) Zhiqiang Jiang et al.   REACTIVE & FUNCTIONAL POLYMERS

Curcumin modulates cell death and is protective in Huntington’s disease model

(2016) Anjalika Chongtham et al.   Scientific Reports

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology

(2016) Rehana Akter et al.   Journal of Diabetes Research

Stabilizing Off-pathway Oligomers by Polyphenol Nanoassemblies for IAPP Aggregation Inhibition

(2016) Praveen Nedumpully-Govindan et al.   Scientific Reports

Mechanism of Inhibition of Human Islet Amyloid Polypeptide-Induced Membrane Damage by a Small Organic Fluorogen

(2016) Xiaoxu Li et al.   Scientific Reports

Curcumin Attenuates Amyloid-β Aggregate Toxicity and Modulates Amyloid-β Aggregation Pathway

(2015) Arjun Thapa et al.   ACS Chemical Neuroscience

Toxic species in amyloid disorders: Oligomers or mature fibrils

(2015) Vibha Taneja et al.   Annals of Indian Academy of Neurology

Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)

(2015) Kwok Kin Cheng et al.   BIOMATERIALS

Curcumin Binding to Beta Amyloid: A Computational Study

(2015) Praveen P. N. Rao et al.   Chemical Biology & Drug Design

Neuronal Aggregates: Formation, Clearance, and Spreading

(2015) Junghyun Lim et al.   DEVELOPMENTAL CELL

Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice

(2015) Daijiro Yanagisawa et al.   NEUROBIOLOGY OF AGING

Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons

(2015) Tomohiro Umeda et al.   Acta Neuropathologica Communications

Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein

(2015) Nuzhat Ahsan et al.   Scientific Reports

Capping of Aβ42 Oligomers by Small Molecule Inhibitors

(2014) Ziao Fu et al.   BIOCHEMISTRY

Synthesis and evaluation of a 18F-curcumin derivate for β-amyloid plaque imaging

(2014) Johanna Rokka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease

(2014) Xueli Zhang et al.   CHEMICAL COMMUNICATIONS

Inhibition of Amyloid Fibril Growth and Dissolution of Amyloid Fibrils by Curcumin-Gold Nanoparticles

(2014) Sharbari Palmal et al.   CHEMISTRY-A EUROPEAN JOURNAL

Curcumin Alters the Salt Bridge-containing Turn Region in Amyloid β(1–42) Aggregates

(2014) Venus Singh Mithu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy

(2014) Nayumi Shigihara et al.   JOURNAL OF CLINICAL INVESTIGATION

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

(2014) Katherine HM Cox et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The Chemistry of Curcumin: From Extraction to Therapeutic Agent

(2014) Kavirayani Priyadarsini   MOLECULES

Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer’s disease

(2014) Zhang Xiong et al.   Pharmacological Reports

Curcumin and neurodegenerative diseases

(2013) Adriana Monroy et al.   BIOFACTORS

Conformational Distribution and α-Helix to β-Sheet Transition of Human Amylin Fragment Dimer

(2013) Ruxi Qi et al.   BIOMACROMOLECULES

Curcumin and Diabetes: A Systematic Review

(2013) Dong-wei Zhang et al.   Evidence-based Complementary and Alternative Medicine

Single-Chain Fragment Variable Passive Immunotherapies for Neurodegenerative Diseases

(2013) Liang Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanistic Insights of Curcumin Interactions with the Core-Recognition Motif of β-Amyloid Peptide

(2013) Priyadharshini Kumaraswamy et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson’s Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy

(2013) Tian-Fang Jiang et al.   Journal of Neuroimmune Pharmacology

Molecular Mechanism of Misfolding and Aggregation of Aβ(13–23)

(2013) Sándor Lovas et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Membrane-Mediated Neuroprotection by Curcumin from Amyloid-β-Peptide-Induced Toxicity

(2013) Arjun Thapa et al.   LANGMUIR

Amylin Uncovered: A Review on the Polypeptide Responsible for Type II Diabetes

(2013) Karen Pillay et al.   Biomed Research International

Curcumin Modulates α-Synuclein Aggregation and Toxicity

(2012) Pradeep K. Singh et al.   ACS Chemical Neuroscience

Curcumin modulates the self-assembly of the islet amyloid polypeptide by disassembling α-helix

(2012) Samuel Sparks et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome?

(2012) Amirhossein Sahebkar   BIOFACTORS

Natural Biomolecules and Protein Aggregation: Emerging Strategies against Amyloidogenesis

(2012) Antonella Sgarbossa   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin Prevents Aggregation in α-Synuclein by Increasing Reconfiguration Rate

(2012) Basir Ahmad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effect of Curcumin on the Stability of Aβ Dimers

(2012) Li Na Zhao et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Curcumin Binds to Aβ1–40 Peptides and Fibrils Stronger Than Ibuprofen and Naproxen

(2012) Son Tung Ngo et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease

(2012) Miriam A Hickey et al.   Molecular Neurodegeneration

AL Amyloidosis

(2012) Estelle Desport et al.   Orphanet Journal of Rare Diseases

Curcumin Promotes A-beta Fibrillation and Reduces Neurotoxicity in Transgenic Drosophila

(2012) Ina Caesar et al.   PLoS One

A Chemical Analog of Curcumin as an Improved Inhibitor of Amyloid Abeta Oligomerization

(2012) Robert A. Orlando et al.   PLoS One

Curcumin Prevents Formation of Polyglutamine Aggregates by Inhibiting Vps36, a Component of the ESCRT-II Complex

(2012) Meenakshi Verma et al.   PLoS One

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

(2012) John M Ringman et al.   Alzheimers Research & Therapy

“Clicked” Sugar–Curcumin Conjugate: Modulator of Amyloid-β and Tau Peptide Aggregation at Ultralow Concentrations

(2011) Sukanta Dolai et al.   ACS Chemical Neuroscience

Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid β-protein fibrils

(2011) Yuichi Masuda et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Amyloidosis: Pathogenesis and New Therapeutic Options

(2011) Giampaolo Merlini et al.   JOURNAL OF CLINICAL ONCOLOGY

The Aggregation-Enhancing Huntingtin N-Terminus Is Helical in Amyloid Fibrils

(2011) V. N. Sivanandam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multitargeting by curcumin as revealed by molecular interaction studies

(2011) Subash C. Gupta et al.   NATURAL PRODUCT REPORTS

Protein aggregate spreading in neurodegenerative diseases: Problems and perspectives

(2011) Seung-Jae Lee et al.   NEUROSCIENCE RESEARCH

Towards a Pharmacophore for Amyloid

(2011) Meytal Landau et al.   PLOS BIOLOGY

Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus

(2010) Xiaoya Zheng et al.   ACTA DIABETOLOGICA

The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity

(2010) Marie Daval et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

(2010) J F Rivera et al.   CELL DEATH AND DIFFERENTIATION

Biochemical and biophysical features of both oligomer/fibril and cell membrane in amyloid cytotoxicity

(2010) Massimo Stefani   FEBS Journal

Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein

(2010) Can Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils

(2010) Mahiuddin Ahmed et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The inhibitory effects of different curcuminoids on β-amyloid protein, β-amyloid precursor protein and β-site amyloid precursor protein cleaving enzyme 1 in swAPP HEK293 cells

(2010) Hongying Liu et al.   NEUROSCIENCE LETTERS

Synthesis and Biological Evaluation of Clicked Curcumin and Clicked KLVFFA Conjugates as Inhibitors of β-Amyloid Fibril Formation

(2009) Myriam Ouberai et al.   BIOCONJUGATE CHEMISTRY

Dynamic α-Helix Structure of Micelle-bound Human Amylin

(2009) Sharadrao M. Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

(2009) Larry Baum et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation

(2009) Yoshiari Shimmyo et al.   NEUROREPORT

Curcumin inhibits aggregation of α-synuclein

(2008) Neeraj Pandey et al.   ACTA NEUROPATHOLOGICA

Structure of α-Helical Membrane-bound Human Islet Amyloid Polypeptide and Its Implications for Membrane-mediated Misfolding

(2008) Melania Apostolidou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease

(2008) A. N. Begum et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS