Single-Chain Fragment Variable Passive Immunotherapies for Neurodegenerative Diseases

Modified Immunotherapies Against Alzheimer's Disease: Toward Safer and Effective Amyloid-β Clearance

(2017) Yan-Jiang Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Prion protein oligomer and its neurotoxicity

(2013) P. Huang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The role of amyloid β in the pathogenesis of Alzheimer's disease

(2013) Barnabas James Gilbert   JOURNAL OF CLINICAL PATHOLOGY

Single chain variable fragment antibodies block aggregation and toxicity induced by familial ALS-linked mutant forms of SOD1

(2013) Ghanashyam D. Ghadge et al.   NEUROBIOLOGY OF DISEASE

Cellular prion protein and Alzheimer disease

(2013) Wataru Kudo et al.   Prion

Parkinson's Disease and Parkinsonism: Neuropathology

(2013) D. W. Dickson   Cold Spring Harbor Perspectives in Medicine

α-Synuclein oligomers and clinical implications for Parkinson disease

(2012) Lorraine V. Kalia et al.   ANNALS OF NEUROLOGY

Recombinant Single-Chain Antibody with the Trojan Peptide Penetratin Positioned in the Linker Region Enables Cargo Transfer Across the Blood–Brain Barrier

(2012) Nives Škrlj et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Engineered antibody approaches for Alzheimer’s disease immunotherapy

(2012) Remy Robert et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Epidemiology of Dementias and Alzheimer’s Disease

(2012) Ana Luisa Sosa-Ortiz et al.   ARCHIVES OF MEDICAL RESEARCH

From α-synuclein to synaptic dysfunctions: New insights into the pathophysiology of Parkinson's disease

(2012) Arianna Bellucci et al.   BRAIN RESEARCH

scFv Antibody: Principles and Clinical Application

(2012) Zuhaida Asra Ahmad et al.   Clinical & Developmental Immunology

Protein aggregation: Mechanisms and functional consequences

(2012) Gaetano Invernizzi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Direct Evidence of Generation and Accumulation of β-Sheet-rich Prion Protein in Scrapie-infected Neuroblastoma Cells with Human IgG1 Antibody Specific for β-Form Prion Protein

(2012) Toshiya Kubota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Anti-prion Antibodies Block Prion Peptide Fibril Formation and Neurotoxicity

(2012) Xing Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion-like spread of protein aggregates in neurodegeneration: Figure 1.

(2012) Magdalini Polymenidou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fusion to a highly charged proteasomal retargeting sequence increases soluble cytoplasmic expression and efficacy of diverse anti-synuclein intrabodies

(2012) Shubhada N. Joshi et al.   mAbs

Immunotherapy in prion disease

(2012) Yvonne Roettger et al.   Nature Reviews Neurology

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Brain delivery of AAV9 expressing an anti-PrP monovalent antibody delays prion disease in mice

(2012) Fabio Moda et al.   Prion

Impaired neurotransmission caused by overexpression of  -synuclein in nigral dopamine neurons

(2012) M. Lundblad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A combined strategy improves the solubility of aggregation-prone single-chain variable fragment antibodies

(2012) Wei Sun et al.   PROTEIN EXPRESSION AND PURIFICATION

Conformation-dependent scFv antibodies specifically recognize the oligomers assembled from various amyloids and show colocalization of amyloid fibrils with oligomers in patients with amyloidoses

(2011) Xi Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Alpha-synuclein synaptic pathology and its implications in the development of novel therapeutic approaches to cure Parkinson's disease

(2011) Arianna Bellucci et al.   BRAIN RESEARCH

Effects of a Brain-Engraftable Microglial Cell Line Expressing Anti-Prion scFv Antibodies on Survival Times of Mice Infected with Scrapie Prions

(2011) Koji Fujita et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Protein aggregates in Huntington's disease

(2011) Montserrat Arrasate et al.   EXPERIMENTAL NEUROLOGY

Cellular prion protein is essential for oligomeric amyloid- -induced neuronal cell death

(2011) W. Kudo et al.   HUMAN MOLECULAR GENETICS

Biological Effects and Use of PrPSc- and PrP-Specific Antibodies Generated by Immunization with Purified Full-Length Native Mouse Prions

(2011) B. Petsch et al.   JOURNAL OF VIROLOGY

Kinase inhibitors modulate huntingtin cell localization and toxicity

(2011) Randy Singh Atwal et al.   Nature Chemical Biology

Specific Binding of the Pathogenic Prion Isoform: Development and Characterization of a Humanized Single-Chain Variable Antibody Fragment

(2011) Nives Škrlj et al.   PLoS One

Bifunctional Anti-Huntingtin Proteasome-Directed Intrabodies Mediate Efficient Degradation of Mutant Huntingtin Exon 1 Protein Fragments

(2011) David C. Butler et al.   PLoS One

Gene–environment interactions: Key to unraveling the mystery of Parkinson's disease

(2011) Hui-Ming Gao et al.   PROGRESS IN NEUROBIOLOGY

Engineered antibody therapies to counteract mutant huntingtin and related toxic intracellular proteins

(2011) David C. Butler et al.   PROGRESS IN NEUROBIOLOGY

Huntington's Disease

(2011) S. Finkbeiner   Cold Spring Harbor Perspectives in Biology

Early or Late-Stage Anti-N-Terminal Huntingtin Intrabody Gene Therapy Reduces Pathological Features in B6.HDR6/1 Mice

(2010) Abigail Snyder-Keller et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Aβ-directed Single-chain Antibody Delivery Via a Serotype-1 AAV Vector Improves Learning Behavior and Pathology in Alzheimer's Disease Mice

(2010) Deborah A Ryan et al.   MOLECULAR THERAPY

Repeat expansion disease: progress and puzzles in disease pathogenesis

(2010) Albert R. La Spada et al.   NATURE REVIEWS GENETICS

Cystamine and intrabody co-treatment confers additional benefits in a fly model of Huntington's disease

(2010) S.F. Bortvedt et al.   NEUROBIOLOGY OF DISEASE

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Gene–environment interactions in Parkinson's disease and other forms of parkinsonism

(2010) Jeffery M. Vance et al.   NEUROTOXICOLOGY

Single-Chain Fv Antibody Fragments Retain Binding Properties of the Monoclonal Antibody Raised Against Peptide P1 of the Human Prion Protein

(2009) Nives Škrlj et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

IgG-single chain Fv fusion protein therapeutic for alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey

(2009) Ruben J. Boado et al.   BIOTECHNOLOGY AND BIOENGINEERING

Conformation-dependent single-chain variable fragment antibodies specifically recognize beta-amyloid oligomers

(2009) Xiao-ping Wang et al.   FEBS LETTERS

Development of vaccination approaches for the treatment of neurological diseases

(2009) Howard J. Federoff   JOURNAL OF COMPARATIVE NEUROLOGY

A novel anti-prion protein monoclonal antibody and its single-chain fragment variable derivative with ability to inhibit abnormal prion protein accumulation in cultured cells

(2009) Yoshihisa Shimizu et al.   MICROBIOLOGY AND IMMUNOLOGY

Development of antibody fragments for immunotherapy of prion diseases

(2008) Vincenza Campana et al.   BIOCHEMICAL JOURNAL

Recent Structural and Computational Insights into Conformational Diseases

(2008) Xavier Fernandez-Busquets et al.   CURRENT MEDICINAL CHEMISTRY

Anti-oligomeric single chain variable domain antibody differentially affects huntingtin and α-synuclein aggregates

(2008) Brent L. Nannenga et al.   FEBS LETTERS

Delivery of single-chain antibodies (scFvs) directed against the 37/67 kDa laminin receptor into mice via recombinant adeno-associated viral vectors for prion disease gene therapy

(2008) C. Zuber et al.   JOURNAL OF GENERAL VIROLOGY

Efficient Isolation of Soluble Intracellular Single-chain Antibodies using the Twin-arginine Translocation Machinery

(2008) Adam C. Fisher et al.   JOURNAL OF MOLECULAR BIOLOGY

Complementarity determining regions of an anti-prion protein scFv fragment orchestrate conformation specificity and antiprion activity

(2008) Andreas Müller-Schiffmann et al.   MOLECULAR IMMUNOLOGY

CNS Delivery of Vectored Prion-specific Single-chain Antibodies Delays Disease Onset

(2008) Charles A Wuertzer et al.   MOLECULAR THERAPY

The POM Monoclonals: A Comprehensive Set of Antibodies to Non-Overlapping Prion Protein Epitopes

(2008) Magdalini Polymenidou et al.   PLoS One

Engineered antibody intervention strategies for Alzheimer's disease and related dementias by targeting amyloid and toxic oligomers

(2008) R. Robert et al.   PROTEIN ENGINEERING DESIGN & SELECTION

An scFv Intrabody against the Nonamyloid Component of α-Synuclein Reduces Intracellular Aggregation and Toxicity

(2007) Sandra M. Lynch et al.   JOURNAL OF MOLECULAR BIOLOGY

Single chain Fv antibodies directed against the 37kDa/67kDa laminin receptor as therapeutic tools in prion diseases

(2007) Chantal Zuber et al.   MOLECULAR IMMUNOLOGY

Intramuscular delivery of a single chain antibody gene reduces brain Aβ burden in a mouse model of Alzheimer's disease

(2007) Yan-Jiang Wang et al.   NEUROBIOLOGY OF AGING