Membrane lipids and transporter function

Retrospect and Prospect of Single Particle Cryo-Electron Microscopy: The Class of Integral Membrane Proteins as an Example

(2020) Shirin Akbar et al.   Journal of Chemical Information and Modeling

The hepatic lipidome: From basic science to clinical translation

(2020) Marit ten Hove et al.   ADVANCED DRUG DELIVERY REVIEWS

Origin and diversification of the cardiolipin biosynthetic pathway in the Eukarya domain

(2020) Luis Alberto Luévano-Martínez et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cardiolipin remodeling in Barth syndrome and other hereditary cardiomyopathies

(2020) Edoardo Bertero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2

(2020) Hongwu Qian et al.   CELL

Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+channels in nanodisc

(2020) Shuai Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter

(2020) Sagnika Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A guide to plasma membrane solute carrier proteins

(2020) Mattia D. Pizzagalli et al.   FEBS Journal

Current View of Ligand and Lipid Recognition by the Menthol Receptor TRPM8

(2020) Ying Yin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ion channels as lipid sensors: from structures to mechanisms

(2020) Mackenzie J. Thompson et al.   Nature Chemical Biology

Structural insight into substrate and inhibitor discrimination by human P-glycoprotein

(2019) Amer Alam et al.   SCIENCE

NPC intracellular cholesterol transporter 1 (NPC1)-mediated cholesterol export from lysosomes

(2019) Suzanne R. Pfeffer   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Protein–Lipid Interactions Probed Using Mass Spectrometry

(2019) Jani Reddy Bolla et al.   Annual Review of Biochemistry

Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues

(2019) Doralicia Casares et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

(2019) Yongchan Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling

(2019) Shengjie Feng et al.   Cell Reports

Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

(2019) Chin et al.   Cells

Lipid-Dependent Regulation of Ion Channels and G Protein–Coupled Receptors: Insights from Structures and Simulations

(2019) Anna L. Duncan et al.   Annual Review of Pharmacology and Toxicology

Endogenous, cholesterol-activated ATP-dependent transport in membrane vesicles from Spodoptera frugiperda cells

(2019) Noora Sjöstedt et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Virus Impact on Lipids and Membranes

(2019) Ellen Ketter et al.   Annual Review of Virology

Quantitative Proteomics and Mechanistic Modeling of Transporter‐mediated Disposition in Non‐Alcoholic Fatty Liver Disease

(2019) Anna Vildhede et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Plasma Membrane Cholesterol Regulates the Allosteric Binding of 1-Methyl-4-Phenylpyridinium to Organic Cation Transporter 2 (SLC22A2)

(2019) Severin Hörmann et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cryo-EM structures of apo and antagonist-bound human Cav3.1

(2019) Yanyu Zhao et al.   NATURE

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

(2019) Simon R. Bushell et al.   Nature Communications

Lipidomics from sample preparation to data analysis: a primer

(2019) Thomas Züllig et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Structure of the human lipid exporter ABCB4 in a lipid environment

(2019) Jeppe A. Olsen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Organic Cation Transporters in Health and Disease

(2019) Hermann Koepsell   PHARMACOLOGICAL REVIEWS

Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity

(2018) Klára Ščupáková et al.   ANALYTICAL CHEMISTRY

Membrane transporter research in times of countless structures

(2018) Markus A. Seeger   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Transporter-Mediated Alterations in Patients With NASH Increase Systemic and Hepatic Exposure to an OATP and MRP2 Substrate

(2018) Izna Ali et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Phospholipid transport protein function at organelle contact sites

(2018) Shamshad Cockcroft et al.   CURRENT OPINION IN CELL BIOLOGY

How lipids contribute to ion channel function, a fat perspective on direct and indirect interactions

(2018) Julio F Cordero-Morales et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Phospholipid subcellular localization and dynamics

(2018) Yanbo Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter

(2018) Louise Laursen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding the diversity of membrane lipid composition

(2018) Takeshi Harayama et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Imaging techniques to study drug transporter function in vivo

(2018) Nicolas Tournier et al.   PHARMACOLOGY & THERAPEUTICS

Post-translational modifications of transporters

(2018) Lindsay C. Czuba et al.   PHARMACOLOGY & THERAPEUTICS

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1

(2018) Xiaojing Pan et al.   SCIENCE

Update on global epidemiology of viral hepatitis and preventive strategies

(2018) Meryem Jefferies et al.   World Journal of Clinical Cases

Changes in drug transport and metabolism and their clinical implications in non-alcoholic fatty liver disease

(2017) Christoph G. Dietrich et al.   Expert Opinion on Drug Metabolism & Toxicology

Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease

(2017) Zoe Hall et al.   HEPATOLOGY

Effect of Liver Disease on Hepatic Transporter Expression and Function

(2017) Nilay Thakkar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Structure of the human multidrug transporter ABCG2

(2017) Nicholas M. I. Taylor et al.   NATURE

Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients

(2017) Franck Chiappini et al.   Scientific Reports

Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol

(2017) David Dickens et al.   Scientific Reports

Significance of oxygen transport through aquaporins

(2017) Janusz J. Zwiazek et al.   Scientific Reports

X-ray structures and mechanism of the human serotonin transporter

(2016) Jonathan A. Coleman et al.   NATURE

Molecular Imaging of Membrane Transporters’ Activity in Cancer: a Picture is Worth a Thousand Tubes

(2015) Aniv Mann et al.   AAPS Journal

General and specific lipid–protein interactions in Na,K-ATPase

(2015) F. Cornelius et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural insights into functional lipid–protein interactions in secondary transporters

(2015) Caroline Koshy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Biological membranes

(2015) H. Watson   Essays in Biochemistry

Phosphatidylethanolamine Is a Key Regulator of Membrane Fluidity in Eukaryotic Cells

(2015) Rosie Dawaliby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment

(2015) Pablo V. Escribá et al.   PROGRESS IN LIPID RESEARCH

Deciphering voltage-gated Na+ and Ca2+ channels by studying prokaryotic ancestors

(2015) William A. Catterall et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications

(2015) T. Heged s et al.   Database-The Journal of Biological Databases and Curation

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

Lipid landscapes and pipelines in membrane homeostasis

(2014) Joost C.M. Holthuis et al.   NATURE

Cholesterol binding to ion channels

(2014) Irena Levitan et al.   Frontiers in Physiology

Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function

(2014) Frances Jane Sharom   Frontiers in Oncology

Prebiotic Systems Chemistry: New Perspectives for the Origins of Life

(2013) Kepa Ruiz-Mirazo et al.   CHEMICAL REVIEWS

Organellar lipidomics—background and perspectives

(2013) Christian Klose et al.   CURRENT OPINION IN CELL BIOLOGY

The ABCs of membrane transporters in health and disease (SLC series): Introduction

(2013) Matthias A. Hediger et al.   MOLECULAR ASPECTS OF MEDICINE

X-ray structure of dopamine transporter elucidates antidepressant mechanism

(2013) Aravind Penmatsa et al.   NATURE

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

(2013) C. A. Shintre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effects of Atorvastatin Therapy on Rheological Characteristics of Erythrocyte Membrane, Serum Lipid Profile and Oxidative Status in Patients with Dyslipidemia

(2012) Hüseyin Avni Uydu et al.   JOURNAL OF MEMBRANE BIOLOGY

Effect of Plasma Membrane Cholesterol Depletion on Glucose Transport Regulation in Leukemia Cells

(2012) Cristiana Caliceti et al.   PLoS One

The bile salt export pump (BSEP) in health and disease

(2012) Ralf Kubitz et al.   Clinics and Research in Hepatology and Gastroenterology

Bioinformatics and Systems Biology of the Lipidome

(2011) Shankar Subramaniam et al.   CHEMICAL REVIEWS

Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis

(2011) Bruno Stieger et al.   Expert Opinion on Drug Metabolism & Toxicology

Specific Lipids Modulate the Transporter Associated with Antigen Processing (TAP)

(2011) Christian Schölz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P-type ATPases at a glance

(2011) M. Bublitz et al.   JOURNAL OF CELL SCIENCE

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis

(2010) Dina G. Tiniakos et al.   Annual Review of Pathology-Mechanisms of Disease

Extensive sphingolipid depletion does not affect lipid raft integrity or lipid raft localization and efflux function of the ABC transporter MRP1

(2010) Karin Klappe et al.   BIOCHEMICAL JOURNAL

Transporters involved in the hepatic uptake of 99mTc-mebrofenin and indocyanine green

(2010) Wilmar de Graaf et al.   JOURNAL OF HEPATOLOGY

Evaluation of 99mTechnetium-Mebrofenin and 99mTechnetium-Sestamibi as Specific Probes for Hepatic Transport Protein Function in Rat and Human Hepatocytes

(2010) Brandon Swift et al.   PHARMACEUTICAL RESEARCH

Effect of Membrane Cholesterol on BSEP/Bsep Activity: Species Specificity Studies for Substrates and Inhibitors

(2009) E. Kis et al.   DRUG METABOLISM AND DISPOSITION

Activity of the Bile Salt Export Pump (ABCB11) Is Critically Dependent on Canalicular Membrane Cholesterol Content

(2009) Coen C. Paulusma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the sodium–potassium pump at 2.4 Å resolution

(2009) Takehiro Shinoda et al.   NATURE

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endoplasmic Reticulum Stress in Disease Pathogenesis

(2008) Jonathan H. Lin et al.   Annual Review of Pathology-Mechanisms of Disease

Interaction of the P-Glycoprotein Multidrug Efflux Pump with Cholesterol: Effects on ATPase Activity, Drug Binding and Transport†

(2008) Paul D. W. Eckford et al.   BIOCHEMISTRY

Localization of the Sodium-Taurocholate cotransporting polypeptide in membrane rafts and modulation of its activity by cholesterol in vitro

(2008) Héctor Molina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Utilization of membrane vesicle preparations to study drug–ABC transporter interactions

(2008) Hristos Glavinas et al.   Expert Opinion on Drug Metabolism & Toxicology

Cholesterol but not association with detergent resistant membranes is necessary for the transport function of MRP2/ABCC2

(2008) Kousei Ito et al.   FEBS LETTERS

Update of the LIPID MAPS comprehensive classification system for lipids

(2008) Eoin Fahy et al.   JOURNAL OF LIPID RESEARCH

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Modulation of ileal bile acid transporter (ASBT) activity by depletion of plasma membrane cholesterol: association with lipid rafts

(2007) Fadi Annaba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY