Changes in drug transport and metabolism and their clinical implications in non-alcoholic fatty liver disease

Non-Alcoholic Steatohepatitis: From Pathophysiology to Novel Therapies

(2016) Daniel Jahn et al.   DIGESTIVE DISEASES

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer

(2016) Amon Asgharpour et al.   JOURNAL OF HEPATOLOGY

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016)   JOURNAL OF HEPATOLOGY

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

(2016) Matthew James Armstrong et al.   LANCET

Thiazolidinediones for nonalcoholic steatohepatitis

(2016) Lingling He et al.   MEDICINE

The Role of Cholesterol in the Pathogenesis of NASH

(2016) George N. Ioannou   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Altered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitis

(2015) BC Ferslew et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis

(2015) John D. Clarke et al.   DIABETES

Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame

(2015) Samar H. Ibrahim et al.   DIGESTIVE DISEASES AND SCIENCES

Farnesoid x receptor in human metabolism and disease: the interplay between gene polymorphisms, clinical phenotypes and disease susceptibility

(2015) Ioannis Koutsounas et al.   Expert Opinion on Drug Metabolism & Toxicology

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

(2015) Robert J. Wong et al.   GASTROENTEROLOGY

Incretin-based therapies for the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis

(2015) Laura J Carbone et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Nonalcoholic steatohepatitis in precision medicine: Unraveling the factors that contribute to individual variability

(2015) John D. Clarke et al.   PHARMACOLOGY & THERAPEUTICS

S2k-Leitlinie nicht alkoholische Fettlebererkrankungen

(2015) E. Roeb et al.   ZEITSCHRIFT FUR GASTROENTEROLOGIE

Development of Hepatocellular Carcinoma in a Murine Model of Nonalcoholic Steatohepatitis Induced by Use of a High-Fat/Fructose Diet and Sedentary Lifestyle

(2014) Joanna K. Dowman et al.   AMERICAN JOURNAL OF PATHOLOGY

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin-Induced Myopathy: 2014 Update

(2014) L B Ramsey et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Sitagliptin attenuates methionine/choline-deficient diet-induced steatohepatitis

(2014) Yun-A. Jung et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial

(2014) Yumie Takeshita et al.   DIABETOLOGIA

Pharmacokinetic and toxicological considerations for the treatment of diabetes in patients with liver disease

(2014) André J Scheen   Expert Opinion on Drug Metabolism & Toxicology

Drug metabolism enzymes in a steatotic model of rat treated with a high fat diet and a low dose of streptozotocin

(2014) A. Vornoli et al.   FOOD AND CHEMICAL TOXICOLOGY

Insulin sensitisers in the treatment of non-alcoholic fatty liver disease: a systematic review.

(2014) D Shyangdan et al.   HEALTH TECHNOLOGY ASSESSMENT

Synergistic interaction between genetics and disease on pravastatin disposition

(2014) John D. Clarke et al.   JOURNAL OF HEPATOLOGY

Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease

(2014) Anaïs Michaut et al.   LIVER INTERNATIONAL

Effect of Diet on Expression of Genes Involved in Lipid Metabolism, Oxidative Stress, and Inflammation in Mouse Liver–Insights into Mechanisms of Hepatic Steatosis

(2014) Helen J. Renaud et al.   PLoS One

Genetic Polymorphism of Cytochrome P450 4F2, Vitamin E Level and Histological Response in Adults and Children with Nonalcoholic Fatty Liver Disease Who Participated in PIVENS and TONIC Clinical Trials

(2014) Shaminie Athinarayanan et al.   PLoS One

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin

(2014) Ligong Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug-Induced Hepatic Steatosis

(2014) Naga Chalasani et al.   SEMINARS IN LIVER DISEASE

Increased Susceptibility to Methotrexate-Induced Toxicity in Nonalcoholic Steatohepatitis

(2014) Rhiannon N. Hardwick et al.   TOXICOLOGICAL SCIENCES

Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes

(2014) Mónika Szabó et al.   TOXICOLOGY IN VITRO

Perspective

(2013) Paul J. Nestel et al.   CURRENT OPINION IN LIPIDOLOGY

Dysregulated Bile Acid Synthesis, Metabolism and Excretion in a High Fat-Cholesterol Diet-Induced Fibrotic Steatohepatitis in Rats

(2013) Xiaofang Jia et al.   DIGESTIVE DISEASES AND SCIENCES

CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis

(2013) Mohamed A. Abdelmegeed et al.   FREE RADICAL BIOLOGY AND MEDICINE

Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis

(2013) Lars P. Bechmann et al.   HEPATOLOGY

High-BMI at diagnosis is associated with inferior survival in patients with osteosarcoma: A report from the Children's Oncology Group

(2013) Sadaf Altaf et al.   PEDIATRIC BLOOD & CANCER

Response to “High BMI at diagnosis is associated with inferior survival in patients with osteosarcoma”

(2013) Sadaf Altaf et al.   PEDIATRIC BLOOD & CANCER

Effect of Caloric Restriction and AMPK Activation on Hepatic Nuclear Receptor, Biotransformation Enzyme, and Transporter Expression in Lean and Obese Mice

(2013) Supriya R. Kulkarni et al.   PHARMACEUTICAL RESEARCH

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease

(2013) April D. Lake et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Peroxisome Proliferator-Activated Receptor Genetic Polymorphisms and Nonalcoholic Fatty Liver Disease: Any Role in Disease Susceptibility?

(2013) Paola Dongiovanni et al.   PPAR Research

Molecular Interactions between NAFLD and Xenobiotic Metabolism

(2013) Adviti Naik et al.   Frontiers in Genetics

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Appropriate Chemotherapy Dosing for Obese Adult Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline

(2012) Jennifer J. Griggs et al.   JOURNAL OF CLINICAL ONCOLOGY

Decreased Mrp2 transport in severe macrovesicular fatty liver grafts

(2012) Atsushi Kudo et al.   JOURNAL OF SURGICAL RESEARCH

Individualized risk for statin-induced myopathy: current knowledge, emerging challenges and potential solutions

(2012) QiPing Feng et al.   PHARMACOGENOMICS

LDL Receptor Knock-Out Mice Are a Physiological Model Particularly Vulnerable to Study the Onset of Inflammation in Non-Alcoholic Fatty Liver Disease

(2012) Veerle Bieghs et al.   PLoS One

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition

(2011) Michael Charlton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Liver function tests and statins

(2011) Philippe J Zamor et al.   CURRENT OPINION IN CARDIOLOGY

Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease

(2011) A. D. Lake et al.   DRUG METABOLISM AND DISPOSITION

Hepatic Pharmacokinetics of Cationic Drugs in a High-Fat Emulsion-Induced Rat Model of Nonalcoholic Steatohepatitis

(2011) P. Li et al.   DRUG METABOLISM AND DISPOSITION

Alteration of Hepatic but Not Renal Transporter Expression in Diet-Induced Obese Mice

(2011) V. R. More et al.   DRUG METABOLISM AND DISPOSITION

Variations in ATP-Binding Cassette Transporter Regulation during the Progression of Human Nonalcoholic Fatty Liver Disease

(2011) R. N. Hardwick et al.   DRUG METABOLISM AND DISPOSITION

Effect of Nuclear Receptor Downregulation on Hepatic Expression of Cytochrome P450 and Transporters in Chronic Hepatitis C in Association with Fibrosis Development

(2011) Kazuhiko Hanada et al.   Drug Metabolism and Pharmacokinetics

Signal profile on Gd-EOB-DTPA-enhanced MR imaging in non-alcoholic steatohepatitis and liver cirrhosis induced in rats: correlation with transporter expression

(2011) Natsuko Tsuda et al.   EUROPEAN RADIOLOGY

Acetaminophen Pharmacokinetics in Children With Nonalcoholic Fatty Liver Disease

(2011) Nicole J Barshop et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Bile acid retention and activation of endogenous hepatic farnesoid-X-receptor in the pathogenesis of fatty liver disease in ob/ob-mice

(2010) Ina V. Martin et al.   BIOLOGICAL CHEMISTRY

Relationship between Kidney Function and Liver Histology in Subjects with Nonalcoholic Steatohepatitis

(2010) G. Targher et al.   Clinical Journal of the American Society of Nephrology

Effect of Obesity on the Pharmacokinetics of Drugs in Humans

(2010) Michael J. Hanley et al.   CLINICAL PHARMACOKINETICS

Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and retinopathy in type 1 diabetic patients

(2010) G. Targher et al.   DIABETOLOGIA

Increased Expression of Hepatic Organic Cation Transporter 1 and Hepatic Distribution of Metformin in High-fat Diet-induced Obese Mice

(2010) Eun-Hee Jang et al.   Drug Metabolism and Pharmacokinetics

High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis

(2010) Rohit Kohli et al.   HEPATOLOGY

Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel

(2010) Robert A.B. van Waterschoot et al.   INTERNATIONAL JOURNAL OF CANCER

Risk of chronic kidney disease in patients with non-alcoholic fatty liver disease: Is there a link?

(2010) Giovanni Targher et al.   JOURNAL OF HEPATOLOGY

The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin-induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver

(2010) Yoshitaka Hasegawa et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis

(2010) Vasilios G Athyros et al.   LANCET

Serum Dipeptidyl Peptidase-4 Activity in Insulin Resistant Patients with Non-Alcoholic Fatty Liver Disease: A Novel Liver Disease Biomarker

(2010) Gábor Firneisz et al.   PLoS One

Advances in individual prediction of methotrexate toxicity: a review

(2009) Kjeld Schmiegelow   BRITISH JOURNAL OF HAEMATOLOGY

Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer

(2009) Ken-ichi Fujita et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats

(2009) Craig D. Fisher et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Alternative transporter pathways in patients with untreated early-stage and late-stage primary biliary cirrhosis

(2009) Yasuaki Takeyama et al.   LIVER INTERNATIONAL

Gene expression in human NAFLD

(2008) Dario Greco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent

(2008) Laura H. Tetri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis

(2008) Craig D. Fisher et al.   ARCHIVES OF TOXICOLOGY

Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na+-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients

(2008) K. Nakai et al.   DRUG METABOLISM AND DISPOSITION

Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

(2008) Mary E. Rinella et al.   JOURNAL OF LIPID RESEARCH

Farnesoid X Receptor Deficiency Induces Nonalcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Knockout Mice Fed a High-Fat Diet

(2008) B. Kong et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Drug-Metabolizing Enzyme and Transporter Expression in a Mouse Model of Diabetes and Obesity

(2008) Qiuqiong Cheng et al.   MOLECULAR PHARMACEUTICS

Acquired Resistance to Acetaminophen Hepatotoxicity is Associated with Induction of Multidrug Resistance-Associated Protein 4 (Mrp4) in Proliferating Hepatocytes

(2008) Lauren M. Aleksunes et al.   TOXICOLOGICAL SCIENCES

Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARα with clofibrate

(2008) Shashikiran Donthamsetty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY