- Home
- Publications
- Publication Search
- Publication Details
Title
A catalog of GWAS fine-mapping efforts in autoimmune disease
Authors
Keywords
-
Journal
AMERICAN JOURNAL OF HUMAN GENETICS
Volume 108, Issue 4, Pages 549-563
Publisher
Elsevier BV
Online
2021-04-02
DOI
10.1016/j.ajhg.2021.03.009
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn’s disease
- (2020) David González-Serna et al. Scientific Reports
- The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy
- (2019) Subhash Mehto et al. MOLECULAR CELL
- Risk variants disrupting enhancers of TH1 and TREG cells in type 1 diabetes
- (2019) Peng Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Crohn’s disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells
- (2019) Stephen M. Matthews et al. PLoS One
- Opportunities and challenges for transcriptome-wide association studies
- (2019) Michael Wainberg et al. NATURE GENETICS
- Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis
- (2019) Tomas Castro-Dopico et al. IMMUNITY
- The Missing Diversity in Human Genetic Studies
- (2019) Giorgio Sirugo et al. CELL
- Identification of rare coding variants in TYK2 protective for rheumatoid arthritis in the Japanese population and their effects on cytokine signalling
- (2019) Tomoki Motegi et al. ANNALS OF THE RHEUMATIC DISEASES
- IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis
- (2019) Hannes Lindahl et al. JOURNAL OF IMMUNOLOGY
- A genetics-led approach defines the drug target landscape of 30 immune-related traits
- (2019) Hai Fang et al. NATURE GENETICS
- Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1
- (2019) Bernard Khor et al. JOURNAL OF IMMUNOLOGY
- An allele-specific functional SNP associated with two systemic autoimmune diseases modulates IRF5 expression by long-range chromatin loop formation
- (2019) Hlaing Nwe Thynn et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Mendelian randomization analysis revealed potential causal factors for systemic lupus erythematosus
- (2019) Xingbo Mo et al. IMMUNOLOGY
- The impact of short tandem repeat variation on gene expression
- (2019) Stephanie Feupe Fotsing et al. NATURE GENETICS
- GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways
- (2019) Elena López-Isac et al. Nature Communications
- Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval
- (2019) Emily A. King et al. PLoS Genetics
- The Post-GWAS Era: From Association to Function
- (2018) Michael D. Gallagher et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Protective C allele of the single-nucleotide polymorphism rs1335532 is associated with strong binding of Ascl2 transcription factor and elevated CD58 expression in B-cells
- (2018) Nikita A. Mitkin et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Comparison of methods for transcriptome imputation through application to two common complex diseases
- (2018) James J. Fryett et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction
- (2018) Gang Li et al. NATURE GENETICS
- Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease
- (2018) Arianne C. Richard et al. PLoS Genetics
- Deciphering the Emerging Complexities of Molecular Mechanisms at GWAS Loci
- (2018) Maren E. Cannon et al. AMERICAN JOURNAL OF HUMAN GENETICS
- simGWAS: a fast method for simulation of large scale case-control GWAS summary statistics
- (2018) Mary Fortune et al. BIOINFORMATICS
- ClinVar at five years: Delivering on the promise
- (2018) Melissa J. Landrum et al. HUMAN MUTATION
- The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019
- (2018) Annalisa Buniello et al. NUCLEIC ACIDS RESEARCH
- Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations
- (2018) Ana Márquez et al. Genome Medicine
- Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b
- (2018) Sebastian Peer et al. Frontiers in Immunology
- Heterozygote galactocerebrosidase (GALC) mutants have reduced remyelination and impaired myelin debris clearance following demyelinating injury
- (2017) Nicole J. Scott-Hewitt et al. HUMAN MOLECULAR GENETICS
- Fine-mapping inflammatory bowel disease loci to single-variant resolution
- (2017) Hailiang Huang et al. NATURE
- Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
- (2017) Katrina M de Lange et al. NATURE GENETICS
- Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease
- (2017) Elizaveta S. Leshchiner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits
- (2017) Felix Grassmann et al. Genome Medicine
- Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease
- (2017) Christopher A. Odhams et al. PLoS Genetics
- Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility
- (2016) Terri H. Finkel et al. BMC Medical Genetics
- GWAS analysis implicates NF-κB-mediated induction of inflammatory T cells in multiple sclerosis
- (2016) J P Hussman et al. GENES AND IMMUNITY
- IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking
- (2016) Durga Sivanesan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Systemic Lupus Erythematosus–Associated Single Nucleotide Polymorphism rs1143678 in Integrin αMCytoplasmic Tail Generates a 14-3-3ζ Binding Site That Is Proinflammatory
- (2016) Li-Teng Ong et al. JOURNAL OF IMMUNOLOGY
- Open Targets: a platform for therapeutic target identification and validation
- (2016) Gautier Koscielny et al. NUCLEIC ACIDS RESEARCH
- The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1
- (2016) Gang Li et al. PLoS Genetics
- Leveraging Functional-Annotation Data in Trans-ethnic Fine-Mapping Studies
- (2015) Gleb Kichaev et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases
- (2015) H. Guo et al. HUMAN MOLECULAR GENETICS
- A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation
- (2015) Ana C. Anderson et al. JOURNAL OF AUTOIMMUNITY
- High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis
- (2015) Philippe Goyette et al. NATURE GENETICS
- The support of human genetic evidence for approved drug indications
- (2015) Matthew R Nelson et al. NATURE GENETICS
- A method to predict the impact of regulatory variants from DNA sequence
- (2015) Dongwon Lee et al. NATURE GENETICS
- An atlas of genetic correlations across human diseases and traits
- (2015) Brendan Bulik-Sullivan et al. NATURE GENETICS
- TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits
- (2015) Dorothée Diogo et al. PLoS One
- Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility
- (2015) Xianyong Yin et al. Nature Communications
- Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci
- (2015) Lam C. Tsoi et al. Nature Communications
- Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci
- (2015) Paul Martin et al. Nature Communications
- BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic -Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2
- (2014) L. Marroqui et al. DIABETES
- Genetic and epigenetic fine mapping of causal autoimmune disease variants
- (2014) Kyle Kai-How Farh et al. NATURE
- Stress-induced RNASET2 overexpression mediates melanocyte apoptosis via the TRAF2 pathway in vitro
- (2014) Q Wang et al. Cell Death & Disease
- Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells
- (2014) Felix J. Hartmann et al. Nature Communications
- Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics
- (2014) Claudia Giambartolomei et al. PLoS Genetics
- Beyond GWASs: Illuminating the Dark Road from Association to Function
- (2013) Stacey L. Edwards et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies
- (2013) David Ellinghaus et al. GASTROENTEROLOGY
- Targeted resequencing identifies defective variants of decoy receptor 3 in pediatric-onset inflammatory bowel disease
- (2013) C J Cardinale et al. GENES AND IMMUNITY
- Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits
- (2013) O. Corradin et al. GENOME RESEARCH
- Resequencing and fine-mapping of the chromosome 12q13-14 locus associated with multiple sclerosis refines the number of implicated genes
- (2013) A. Cortes et al. HUMAN MOLECULAR GENETICS
- Genetics of rheumatoid arthritis contributes to biology and drug discovery
- (2013) Yukinori Okada et al. NATURE
- Negligible impact of rare autoimmune-locus coding-region variants on missing heritability
- (2013) Karen A. Hunt et al. NATURE
- NIH Seeks Better Database for Genetic Diagnosis
- (2013) Eliot Marshall SCIENCE
- An Enhancer Element Harboring Variants Associated with Systemic Lupus Erythematosus Engages the TNFAIP3 Promoter to Influence A20 Expression
- (2013) Shaofeng Wang et al. PLoS Genetics
- Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis
- (2013) Mélissa Beaudoin et al. PLoS Genetics
- Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes
- (2012) Chris Wallace et al. HUMAN MOLECULAR GENETICS
- Monocytes from Irf5-/- Mice Have an Intrinsic Defect in Their Response to Pristane-Induced Lupus
- (2012) L. Yang et al. JOURNAL OF IMMUNOLOGY
- TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
- (2012) Adam P. Gregory et al. NATURE
- High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
- (2012) Steve Eyre et al. NATURE GENETICS
- Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
- (2012) Yukinori Okada et al. NATURE GENETICS
- Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
- (2012) M. T. Maurano et al. SCIENCE
- Emerging patterns of genetic overlap across autoimmune disorders
- (2012) Corinne Richard-Miceli et al. Genome Medicine
- Proteome-Wide Analysis of Disease-Associated SNPs That Show Allele-Specific Transcription Factor Binding
- (2012) Falk Butter et al. PLoS Genetics
- PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic -Cell Apoptosis via Regulation of the BH3-Only Protein Bim
- (2011) I. Santin et al. DIABETES
- Evidence for two independent associations with type 1 diabetes at the 12q13 locus
- (2011) K L Keene et al. GENES AND IMMUNITY
- Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene
- (2011) Lucy J. Davison et al. HUMAN MOLECULAR GENETICS
- Colonic Eosinophilic Inflammation in Experimental Colitis Is Mediated by Ly6Chigh CCR2+ Inflammatory Monocyte/Macrophage-Derived CCL11
- (2011) A. Waddell et al. JOURNAL OF IMMUNOLOGY
- The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+ T Cell Proliferation
- (2011) D. M. Kofler et al. JOURNAL OF IMMUNOLOGY
- Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
- (2011) Indra Adrianto et al. NATURE GENETICS
- A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease
- (2011) Patrick Brest et al. NATURE GENETICS
- Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
- (2011) Manuel A Rivas et al. NATURE GENETICS
- The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
- (2011) Zhihua Liu et al. NATURE IMMUNOLOGY
- A20-binding inhibitor of NF- B (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein activation and protects from inflammatory disease
- (2011) J. Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects
- (2010) Kai Wang et al. HUMAN MOLECULAR GENETICS
- Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis
- (2010) Ulrike Hüffmeier et al. NATURE GENETICS
- Crohn's disease-associated adherent-invasiveE.âcoliare selectively favoured by impaired autophagy to replicate intracellularly
- (2009) Pierre Lapaquette et al. CELLULAR MICROBIOLOGY
- PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic -Cell Apoptosis
- (2009) F. Moore et al. DIABETES
- Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
- (2009) L. A. Hindorff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes
- (2009) S. Nejentsev et al. SCIENCE
- Detecting shared pathogenesis from the shared genetics of immune-related diseases
- (2008) Alexandra Zhernakova et al. NATURE REVIEWS GENETICS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started