Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b

Elevated expression of granulocyte-macrophage colony-stimulating factor receptor in multiple sclerosis lesions

(2018) Jaime Imitola et al.   JOURNAL OF NEUROIMMUNOLOGY

IL-3 Is a Marker of Encephalitogenic T Cells, but Not Essential for CNS Autoimmunity

(2018) Priscilla W. Lee et al.   Frontiers in Immunology

Targeting the GM-CSF receptor for the treatment of CNS autoimmunity

(2017) Igal Ifergan et al.   JOURNAL OF AUTOIMMUNITY

Multiple sclerosis: experimental models and reality

(2016) Hans Lassmann et al.   ACTA NEUROPATHOLOGICA

GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation

(2016) Burkhard Becher et al.   IMMUNITY

An interferon-β-resistant and NLRP3 inflammasome–independent subtype of EAE with neuronal damage

(2016) Makoto Inoue et al.   NATURE NEUROSCIENCE

Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy

(2015) Javad Rasouli et al.   JOURNAL OF IMMUNOLOGY

Pivotal Roles of GM-CSF in Autoimmunity and Inflammation

(2015) Aoi Shiomi et al.   MEDIATORS OF INFLAMMATION

STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation

(2014) Wanqiang Sheng et al.   CELL RESEARCH

Cutting Edge: IL-21 Is Not Essential for Th17 Differentiation or Experimental Autoimmune Encephalomyelitis

(2014) J. M. Coquet et al.   JOURNAL OF IMMUNOLOGY

A Multiple Sclerosis–Associated Variant of CBLB Links Genetic Risk with Type I IFN Function

(2014) Klarissa Hanja Stürner et al.   JOURNAL OF IMMUNOLOGY

IL-17 and GM-CSF Expression Are Antagonistically Regulated by Human T Helper Cells

(2014) R. Noster et al.   Science Translational Medicine

Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells

(2014) Felix J. Hartmann et al.   Nature Communications

Using EAE to better understand principles of immune function and autoimmune pathology

(2013) Manu Rangachari et al.   JOURNAL OF AUTOIMMUNITY

GM-CSF as a therapeutic target in inflammatory diseases

(2013) Annemarie van Nieuwenhuijze et al.   MOLECULAR IMMUNOLOGY

Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells

(2013) Thomas Gruber et al.   Journal of Molecular Cell Biology

Casitas B Lineage Lymphoma b Is a Key Regulator of Peripheral Tolerance in Systemic Lupus Erythematosus

(2012) Diana Gómez-Martín et al.   ARTHRITIS AND RHEUMATISM

The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling

(2012) Sophie E. Broughton et al.   IMMUNOLOGICAL REVIEWS

Multiple Sclerosis: Pathogenesis and Treatment

(2011) Ingrid Loma et al.   Current Neuropharmacology

Reinforcement of cancer immunotherapy by adoptive transfer of cblb -deficient CD8+ T cells combined with a DC vaccine

(2011) Christina Lutz-Nicoladoni et al.   IMMUNOLOGY AND CELL BIOLOGY

NF-κB and BRG1 bind a distal regulatory element in the IL-3/GM-CSF locus

(2011) Andrea L. Wurster et al.   MOLECULAR IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Cbl-b-/- T Cells Demonstrate In Vivo Resistance to Regulatory T Cells but a Context-Dependent Resistance to TGF- 

(2010) C. O. Adams et al.   JOURNAL OF IMMUNOLOGY

The Human IL-3/Granulocyte-Macrophage Colony-Stimulating Factor Locus Is Epigenetically Silent in Immature Thymocytes and Is Progressively Activated during T Cell Development

(2010) F. Mirabella et al.   JOURNAL OF IMMUNOLOGY

Association of the CBLB gene with multiple sclerosis: new evidence from a replication study in an Italian population

(2010) L. Corrado et al.   JOURNAL OF MEDICAL GENETICS

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis

(2010) Serena Sanna et al.   NATURE GENETICS

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

(2009) T. R. Hercus et al.   BLOOD

IL-17 Signaling-Independent Central Nervous System Autoimmunity Is Negatively Regulated by TGF- 

(2009) I. Gonzalez-Garcia et al.   JOURNAL OF IMMUNOLOGY

PKC-  Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation

(2009) T. Gruber et al.   Science Signaling

IL‐21 and IL‐21R are not required for development of Th17 cells and autoimmunityin vivo

(2008) Ivo Sonderegger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of inflammatory responses by IL-17F

(2008) Xuexian O. Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

T-Cell Receptor-Induced NF- B Activation Is Negatively Regulated by E3 Ubiquitin Ligase Cbl-b

(2008) G. Qiao et al.   MOLECULAR AND CELLULAR BIOLOGY

Study of Cbl-b dynamics in peripheral blood lymphocytes isolated from patients with multiple sclerosis

(2008) Wen-bin Zhou et al.   NEUROSCIENCE LETTERS