Article
Oncology
Haoxue Wang, Ying Zhu, Hongda Chen, Nan Yang, Xiaoyang Wang, Bin Li, Pingting Ying, Heng He, Yimin Cai, Ming Zhang, Siyuan Niu, Yue Li, Zequn Lu, Xiating Peng, Danyi Zou, Rong Zhong, Jiang Chang, Min Dai, Jianbo Tian, Xiaoping Miao
Summary: This study comprehensively characterized the role of ATF1 in CRC through RNA-seq and ChIP-seq assays, identifying a specific variant, rs7017386, associated with the risk of CRC by affecting the expression of CCAT1 and PVT1 in the Wnt pathway. Mechanistically, the rs7017386 allele was found to enhance ATF1 binding affinity and promote the expressions of PVT1 and CCAT1 by forming a long-range chromatin loop, resulting in the activation of the Wnt pathway in CRC progression.
Review
Cell Biology
Yuhong Liu, Zhihua Tu, Xi Zhang, Keqian Du, Zhengquan Xie, Zhiming Lin
Summary: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease with a complex pathogenesis. Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication of SLE that involves the nervous system and produces neurological or psychiatric symptoms. The mechanisms of NPSLE involve genetic factors, blood-brain barrier dysfunction, vascular lesions, multiple autoimmune antibodies, cytokines, and neuronal cell death. Due to the complexity and clinical overlap with other neurological or psychiatric disorders, the accurate diagnosis and treatment of NPSLE is challenging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Chemistry, Medicinal
Sajjad Chamani, Maryam Moossavi, Ali Naghizadeh, Mitra Abbasifard, Muhammed Majeed, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Systemic autoimmune diseases are characterized by immune system dysregulation, leading to immune cell activation, inflammation, and multi-organ impairment. Curcumin, a phenolic ingredient extracted from turmeric, has various functions such as inhibiting inflammation and oxidative stress. However, its immunomodulatory effects on immune reactions/processes are still largely unknown.
PHYTOTHERAPY RESEARCH
(2022)
Review
Immunology
Ying Zhu, Benqiao Wang, Yuehan Hao, Ruixia Zhu
Summary: Multiple reports have shown the co-existence of autoimmune diseases and myasthenia gravis (MG). This review explores the clinical presentations of autoimmune diseases in MG and investigates whether the presence of autoimmune diseases affects the severity and treatment strategies of MG. The review reveals a higher frequency of autoimmune diseases in MG patients, particularly in women. Most autoimmune comorbidities are linked to AChR-MG, with thyroid disorders, systemic lupus erythematosus, and vitiligo being the most common. MG can also coexist with neurological autoimmune diseases, with neuromyelitis optica (NMO) being the most common. The review suggests that autoimmune diseases occur more often in early-onset MG and do not influence the clinical course of MG.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Walaa K. Mousa, Fadia Chehadeh, Shannon Husband
Summary: The interaction between gut microbes and the immune system plays a crucial role in the development and treatment of systemic autoimmune diseases. Understanding how gut microbes can trigger or protect from these diseases can help us tackle them through dietary and lifestyle changes, microbiome-based therapies, identification of diagnostic biomarkers, and intervention with microbial population changes. Considering the microbiome signature as a key player in systemic autoimmune diseases holds promise in transforming these untreatable diseases into manageable or preventable ones.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Lingxiao Xu, Jian Zhao, Qing Sun, Xue Xu, Lei Wang, Ting Liu, Yunjuan Wu, Jingfeng Zhu, Linyu Geng, Yun Deng, Alexander Awgulewitsch, Diane L. Kamen, Jim C. Oates, Prithvi Raj, Edward K. Wakeland, R. Hal Scofield, Joel M. Guthridge, Judith A. James, Bevra H. Hahn, Deborah K. McCurdy, Fang Wang, Miaojia Zhang, Wenfeng Tan, Gary S. Gilkeson, Betty P. Tsao
Summary: This research found two novel SAT1 LOF variants through whole exome sequencing in families with multiple siblings affected by systemic lupus erythematosus (SLE), demonstrating their association with SLE. The study highlights the pathogenic role of dysregulated polyamine catabolism in lupus.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Biology
Pawel Joachimiak, Adam Ciesiolka, Emilia Kozlowska, Pawel M. Switonski, Grzegorz Figura, Agata Ciolak, Grazyna Adamek, Magdalena Surdyka, Zaneta Kalinowska-Poska, Maciej Figiel, Nicholas S. S. Caron, Michael R. R. Hayden, Agnieszka Fiszer
Summary: This study used SNP variants to quantitatively determine the allele-specific expression levels in patient-derived cell lines for spinocerebellar ataxia type 3 (SCA3) and Huntington's disease (HD). They found differences in allele expression levels and developed a reliable and quantitative method using SNP-based droplet digital PCR (ddPCR) to analyze low abundant transcripts. This allele-selective approach provides insights into allele-related mechanisms and can improve understanding of polyglutamine diseases.
Article
Rheumatology
Sebastien Sanges, Lisa Rice, Ly Tu, Eleanor Valenzi, Jean-Luc Cracowski, David Montani, Julio C. Mantero, Camille Ternynck, Guillemette Marot, Andreea M. Bujor, Eric Hachulla, David Launay, Marc Humbert, Christophe Guignabert, Robert Lafyatis
Summary: This study examined the serum proteome of patients with systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) and identified two proteins that were significantly correlated with pulmonary vascular resistance (PVR), potentially providing biomarkers for earlier diagnosis and treatment.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Charalampos Papagoras, George E. Fragoulis, Nikoleta Zioga, Theodora Simopoulou, Kleopatra Deftereou, Eleni Kalavri, Evangelia Zampeli, Nafsika Gerolymatou, Evangelia Kataxaki, Konstantinos Melissaropoulos, Stylianos Panopoulos, Kalliopi Fragiadaki, Gerasimos Evangelatos, Vasiliki-Kalliopi Bournia, Aikaterini Arida, Anastasios Karamanakos, Maria Pappa, Alexandros Panagiotopoulos, Christos Koutsianas, Georgia Mparouta, Theodoros Dimitroulas, Stamatis-Nick Liossis, Maria G. Tektonidou, Evrydiki Kravvariti, Nikolaos Kougkas, Panagiotis Georgiou, Paraskevi Voulgari, Antonia Elezoglou, Dimitrios P. Bogdanos, Dimitrios Vassilopoulos, Petros P. Sfikakis
Summary: Vaccinated patients with systemic rheumatic diseases who experience breakthrough COVID-19 have better outcomes compared to unvaccinated patients with similar disease characteristics. This highlights the importance of COVID-19 vaccination in vulnerable populations like those with SRDs.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Tea Gegenava, Federico Fortuni, Nina Marijn van Leeuwen, Anders H. Tennoe, Anna-Maria Hoffmann-Vold, Ruxandra Jurcut, Adrian Giuca, Laura Groseanu, Felix Tanner, Oliver Distler, Jeroen J. Bax, Jeska De Vries-Bouwstra, Nina Ajmone Marsan
Summary: This study aimed to assess the impact of sex differences on cardiovascular outcomes in patients with systemic sclerosis (SSc). The results showed that male SSc patients had a higher incidence of cardiovascular events, and the adjusted left ventricular global longitudinal strain may explain this gender difference in outcomes.
Article
Rheumatology
Jingru Tian, Dingyao Zhang, Xu Yao, Yaqing Huang, Qianjin Lu
Summary: This study estimated the epidemiology of SLE globally, finding variations in incidence and prevalence rates across different countries and regions. It also highlighted the impact of gender, age, and prevalence estimation method on the findings. SLE was found to occur more frequently in high-income countries.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Christopher P. Denton, Shiwen Xu, Fenge Zhang, Rory H. Maclean, Kristina E. N. Clark, Signe Borchert, Rizwan Hussain, Joerg Klingelhofer, Jonas Hallen, Voon H. Ong
Summary: This study investigated the role of S100A4 in fibroblast activation in systemic sclerosis (SSc). The results showed that S100A4 concentration was higher in SSc patients compared to healthy controls, and was associated with interstitial lung disease and scleroderma renal crisis. In vitro experiments demonstrated that S100A4 promoted the expression of profibrotic genes in SSc fibroblasts, while a neutralizing antibody against S100A4 reduced this expression. These findings provide evidence for the profibrotic role of S100A4 in SSc and suggest its potential as a therapeutic target.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Antonis Fanouriakis, Myrto Kostopoulou, Jeanette Andersen, Martin Aringer, Laurent Arnaud, Sang-Cheol Bae, John Boletis, Ian N. Bruce, Ricard Cervera, Andrea Doria, Thomas Doerner, Richard A. Furie, Dafna D. Gladman, Frederic A. Houssiau, Luis Sousa Ines, David Jayne, Marios Kouloumas, Laszlo Kovacs, Chi Chiu Mok, Eric F. Morand, Gabriella Moroni, Marta Mosca, Johanna Mucke, Chetan B. Mukhtyar, Gyoergy Nagy, Sandra Navarra, Ioannis Parodis, Jose M. Pego-Reigosa, Michelle Petri, Bernardo A. Pons-Estel, Matthias Schneider, Josef S. Smolen, Elisabet Svenungsson, Yoshiya Tanaka, Maria G. Tektonidou, Y. K. Onno Teng, Angela Tincani, Edward M. Vital, Ronald F. van Vollenhoven, Chris Wincup, George Bertsias, Dimitrios T. Boumpas
Summary: The EULAR recommendations for the management of systemic lupus erythematosus (SLE) have been updated based on emerging new evidence. The updated recommendations provide consensus guidance on the use of various medications and treatment strategies to control the disease, as well as recommendations for assessing treatment response and tapering therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ali Duarte-Garcia, Mehmet Hocaoglu, Maria Valenzuela-Almada, Shirley-Ann Osei-Onomah, Jesse Y. Dabit, Alain Sanchez-Rodriguez, Stephanie Q. Duong, Rachel E. Giblon, Hannah E. Langenfeld, Graciela S. Alarcon, Charles G. Helmick, Cynthia S. Crowson
Summary: The incidence and prevalence of systemic lupus erythematosus (SLE) are increasing in the US population, potentially due to the rising ethnic diversity. However, the severity of SLE and the survival gap between SLE and the general population have remained unchanged over time.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Marianna Mitratza, Bart Klijs, A. Elisabeth Hak, Jan W. P. F. Kardaun, Anton E. Kunst
Summary: This study aimed to assess the mortality rate of systemic autoimmune diseases (SAIDs) and found that SAIDs contribute to mortality through multiple comorbidities, with particularly strong associations with diseases of the musculoskeletal system, genitourinary system, and influenza.
Article
Endocrinology & Metabolism
Shan-Shan Dong, Shi Yao, Yi-Xiao Chen, Yan Guo, Yu-Jie Zhang, Hui-Min Niu, Ruo-Han Hao, Hui Shen, Qing Tian, Hong-Wen Deng, Tie-Lin Yang
INTERNATIONAL JOURNAL OF OBESITY
(2019)
Article
Endocrinology & Metabolism
Yan Zhang, Xiao-Feng Chen, Jing Li, Fang He, Xu Li, Yan Guo
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Biochemical Research Methods
Jia-Bin Chen, Shan-Shan Dong, Shi Yao, Yuan-Yuan Duan, Wei-Xin Hu, Hao Chen, Nai-Ning Wang, Xiao-Feng Chen, Ruo-Han Hao, Hlaing Nwe Thynn, Ming-Rui Guo, Yu-Jie Zhang, Yu Rong, Yi-Xiao Chen, Fu-Ling Zhou, Yan Guo, Tie-Lin Yang
Article
Medicine, Research & Experimental
Xiao-Feng Chen, Ming-Rui Guo, Yuan-Yuan Duan, Feng Jiang, Hao Wu, Shan-Shan Dong, Xiao-Rong Zhou, Hlaing Nwe Thynn, Cong-Cong Liu, Lin Zhang, Yan Guo, Tie-Lin Yang
Article
Endocrinology & Metabolism
Shi Yao, Hao Wu, Jing-Miao Ding, Zhuo-Xin Wang, Tahir Ullah, Shan-Shan Dong, Hao Chen, Yan Guo
Summary: This study identified multiple candidate genes for childhood BMI through TWAS analysis, some of which were only identified in specific tissues. Some of the genes were functionally related to obesity phenotypes, including genes with differential expression during the differentiation of fat cells. These results provide new clues for understanding the genetic mechanism of childhood obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Genetics & Heredity
Shan-Shan Dong, Kun Zhang, Yan Guo, Jing-Miao Ding, Yu Rong, Jun-Cheng Feng, Shi Yao, Ruo-Han Hao, Feng Jiang, Jia-Bin Chen, Hao Wu, Xiao-Feng Chen, Tie-Lin Yang
Summary: The study identified potential causal effects of childhood obesity on 60 adult traits, but found that the detrimental effects on disease-related traits were no longer present after accounting for adult BMI. The associations between childhood BMI and increased risks of diseases in adulthood are likely attributed to individuals remaining obese in later life.
Article
Oncology
Junhe Zhang, Hao Chen, Chen Chen, Haimeng Liu, Yurou He, Junli Zhao, Peiyan Yang, Qinwen Mao, Haibin Xia
Summary: Utilizing MSCs as potential carriers and regulating adenovirus replication with a Tet-on system has shown effective treatment against glioma. The novel adenovirus demonstrated efficient replication and killing of glioma cells in vitro, with effective regulation by doxycycline. The doxycycline-induced group with dual expression of IL24 and Endostatin showed significantly greater antitumor effects in a xenograft model of glioma.
Article
Biochemical Research Methods
Wei-Xin Hu, Yu Rong, Yan Guo, Feng Jiang, Wen Tian, Hao Chen, Shan-Shan Dong, Tie-Lin Yang
Summary: Research shows that designing sgRNAs with on-target mismatches can improve binding activity and reduce off-target effects. A web tool named ExsgRNA is provided for optimizing sgRNA design.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Endocrinology & Metabolism
Dong-Li Zhu, Xiao-Feng Chen, Xiao-Rong Zhou, Shou-Ye Hu, Xiao-Mei Tuo, Ruo-Han Hao, Shan-Shan Dong, Feng Jiang, Yu Rong, Tie-Lin Yang, Zhi Yang, Yan Guo
Summary: Through bioinformatics and functional experiments, a potentially functional single-nucleotide polymorphism (SNP) located in an enhancer element was identified. This SNP, by altering the binding affinity of a transcription factor, increased the expression of the target gene SOX6, thus affecting the susceptibility to osteoporosis. This study revealed the mechanisms by which noncoding genetic variants impact osteoporosis through long-range gene regulatory mechanisms.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)