An Enhancer Element Harboring Variants Associated with Systemic Lupus Erythematosus Engages the TNFAIP3 Promoter to Influence A20 Expression

Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians

(2012) Wanling Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Brief Report: Candidate gene study in systemic sclerosis identifies a rare and functional variant of the TNFAIP3 locus as a risk factor for polyautoimmunity

(2012) Eugénie Koumakis et al.   ARTHRITIS AND RHEUMATISM

Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways

(2012) Samuel E. Vaughn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

SATB1-mediated functional packaging of chromatin into loops

(2012) Terumi Kohwi-Shigematsu et al.   METHODS

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

The genetics of lupus: a functional perspective

(2012) Sandra G Guerra et al.   ARTHRITIS RESEARCH & THERAPY

Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases

(2011) S L Musone et al.   GENES AND IMMUNITY

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

(2011) Indra Adrianto et al.   NATURE GENETICS

Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis

(2011) Gianna Elena Hammer et al.   NATURE IMMUNOLOGY

Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding

(2011) Trevor Siggers et al.   NATURE IMMUNOLOGY

Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population

(2010) P. Dieude et al.   ANNALS OF THE RHEUMATIC DISEASES

B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice

(2010) Y. Chu et al.   BLOOD

A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies

(2010) Nadine Hövelmeyer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity

(2010) Rita M. Tavares et al.   IMMUNITY

A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility

(2010) Yuta Kochi et al.   NATURE GENETICS

Multiple common variants for celiac disease influencing immune gene expression

(2010) Patrick C A Dubois et al.   NATURE GENETICS

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas

(2009) K. Honma et al.   BLOOD

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF- B signalling

(2009) G. Trynka et al.   GUT

TNFAIP3(A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

(2009) Roland Schmitz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A20 is targeted by promoter methylation, deletion and inactivating mutation in MALT lymphoma

(2009) E Chanudet et al.   LEUKEMIA

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

(2009) Mara Compagno et al.   NATURE

Frequent inactivation of A20 in B-cell lymphomas

(2009) Motohiro Kato et al.   NATURE

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

(2009) Rajan P Nair et al.   NATURE GENETICS

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ubiquitin-Editing Enzyme A20 Restricts Nucleotide-Binding Oligomerization Domain Containing 2-Triggered Signals

(2008) Osamu Hitotsumatsu et al.   IMMUNITY

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

(2008) Robert R Graham et al.   NATURE GENETICS

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

(2008) Stacy L Musone et al.   NATURE GENETICS