Transcription as a source of genome instability

The roles of transcription and genotoxins underlying p53 mutagenesis in vivo

(2011) Barbara E. Wright et al.   CARCINOGENESIS

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

(2011) Katrin Paeschke et al.   CELL

The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores

(2011) Rodrigo Bermejo et al.   CELL

Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

(2011) Roberto Chiarle et al.   CELL

Linking RNA Polymerase Backtracking to Genome Instability in E. coli

(2011) Dipak Dutta et al.   CELL

Transcription-induced DNA toxicity at trinucleotide repeats

(2011) Yunfu Lin et al.   CELL CYCLE

Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast

(2011) Nayun Kim et al.   DNA REPAIR

G-quadruplex-induced instability during leading-strand replication

(2011) Judith Lopes et al.   EMBO JOURNAL

Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles

(2011) Belén Gómez-González et al.   EMBO JOURNAL

R-loop-mediated genomic instability is caused by impairment of replication fork progression

(2011) W. Gan et al.   GENES & DEVELOPMENT

TP53 Mutational signature for aristolochic acid: an environmental carcinogen

(2011) Masaaki Moriya et al.   INTERNATIONAL JOURNAL OF CANCER

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

(2011) Anne Helmrich et al.   MOLECULAR CELL

RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability

(2011) Lamia Wahba et al.   MOLECULAR CELL

Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability

(2011) Hannah E. Mischo et al.   MOLECULAR CELL

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

DNA slip-outs cause RNA polymerase II arrest in vitro : potential implications for genetic instability

(2011) Viviana Salinas-Rios et al.   NUCLEIC ACIDS RESEARCH

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

(2011) N. Kim et al.   SCIENCE

Break-Induced Replication Is Highly Inaccurate

(2011) Angela Deem et al.   PLOS BIOLOGY

Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX

(2011) María S. Domínguez-Sánchez et al.   PLoS Genetics

The interface between transcription and mRNP export: From THO to THSC/TREX-2

(2010) Ana G. Rondón et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

What happens when replication and transcription complexes collide?

(2010) Richard T. Pomerantz et al.   CELL CYCLE

Transcription-Dependent Cytosine Deamination Is a Novel Mechanism in Ultraviolet Light-Induced Mutagenesis

(2010) Giel Hendriks et al.   CURRENT BIOLOGY

Is RecG a general guardian of the bacterial genome?

(2010) Christian J. Rudolph et al.   DNA REPAIR

Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

(2010) A. El Hage et al.   GENES & DEVELOPMENT

Bidirectional transcription stimulates expansion and contraction of expanded (CTG)•(CAG) repeats

(2010) Masayuki Nakamori et al.   HUMAN MOLECULAR GENETICS

Transcription-Associated Mutation in Bacillus subtilis Cells under Stress

(2010) C. Pybus et al.   JOURNAL OF BACTERIOLOGY

Deoxyuridine Triphosphate Incorporation during Somatic Hypermutation of Mouse VkOx Genes after Immunization with Phenyloxazolone

(2010) B. Roche et al.   JOURNAL OF IMMUNOLOGY

Abasic Sites in the Transcribed Strand of Yeast DNA Are Removed by Transcription-Coupled Nucleotide Excision Repair

(2010) N. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Convergent Transcription through a Long CAG Tract Destabilizes Repeats and Induces Apoptosis

(2010) Y. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinguishing the Roles of Topoisomerases I and II in Relief of Transcription-Induced Torsional Stress in Yeast rRNA Genes

(2010) S. L. French et al.   MOLECULAR AND CELLULAR BIOLOGY

Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions

(2010) Robert W Maul et al.   NATURE IMMUNOLOGY

Role of transcript and interplay between transcription and replication in triplet-repeat instability in mammalian cells

(2010) P. M. Rindler et al.   NUCLEIC ACIDS RESEARCH

Role for topoisomerase 1 in transcription-associated mutagenesis in yeast

(2010) M. J. Lippert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae

(2010) T. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and implications of transcription blockage by guanine-rich DNA sequences

(2010) B. P. Belotserkovskii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Mutagenesis and Unique Mutation Signature Associated with Mitotic Gene Conversion

(2010) W. M. Hicks et al.   SCIENCE

Co-Orientation of Replication and Transcription Preserves Genome Integrity

(2010) Anjana Srivatsan et al.   PLoS Genetics

Stimulation of direct-repeat recombination by RNA polymerase III transcription

(2009) M.C. Díaz de la Loza et al.   DNA REPAIR

Ribonuclease H: the enzymes in eukaryotes

(2009) Susana M. Cerritelli et al.   FEBS Journal

Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset

(2009) Meera Swami et al.   HUMAN MOLECULAR GENETICS

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

(2009) L. S. Waters et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

(2009) Renee D. Paulsen et al.   MOLECULAR CELL

Highly Transcribed RNA Polymerase II Genes Are Impediments to Replication Fork Progression in Saccharomyces cerevisiae

(2009) Anna Azvolinsky et al.   MOLECULAR CELL

Transcription-associated recombination in eukaryotes: link between transcription, replication and recombination

(2009) P. Gottipati et al.   MUTAGENESIS

dUTP incorporation into genomic DNA is linked to transcription in yeast

(2009) Nayun Kim et al.   NATURE

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

(2009) Sandie Tuduri et al.   NATURE CELL BIOLOGY

Mutation patterns in cancer genomes

(2009) A. F. Rubin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progressive GAA·TTC Repeat Expansion in Human Cell Lines

(2009) Scott Ditch et al.   PLoS Genetics

Gene transcription increases DNA damage-induced mutagenesis in mammalian stem cells

(2008) Giel Hendriks et al.   DNA REPAIR

Transcription-coupled DNA repair: two decades of progress and surprises

(2008) Philip C. Hanawalt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spt2p Defines a New Transcription-Dependent Gross Chromosomal Rearrangement Pathway

(2008) Nilabja Sikdar et al.   PLoS Genetics