Analysis of polygenic risk score usage and performance in diverse human populations

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

(2019) Mashaal Sohail et al.   eLife

Reduced signal for polygenic adaptation of height in UK Biobank

(2019) Jeremy J Berg et al.   eLife

Detecting Polygenic Adaptation in Admixture Graphs

(2018) Fernando Racimo et al.   GENETICS

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

The personal and clinical utility of polygenic risk scores

(2018) Ali Torkamani et al.   NATURE REVIEWS GENETICS

Global genetic differentiation of complex traits shaped by natural selection in humans

(2018) Jing Guo et al.   Nature Communications

Cardiovascular disease: The rise of the genetic risk score

(2018) Joshua W. Knowles et al.   PLOS MEDICINE

Detecting Polygenic Adaptation in Admixture Graphs

(2018) Fernando Racimo et al.   GENETICS

Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia

(2018) David Curtis   PSYCHIATRIC GENETICS

Generalizing polygenic risk scores from Europeans to Hispanics/Latinos

(2018) Kelsey E. Grinde et al.   GENETIC EPIDEMIOLOGY

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability

(2017) L E Duncan et al.   MOLECULAR PSYCHIATRY

Cultural evolutionary theory: How culture evolves and why it matters

(2017) Nicole Creanza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A machine-learning heuristic to improve gene score prediction of polygenic traits

(2017) Guillaume Paré et al.   Scientific Reports

Common genetic variants and subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA)

(2016) Jose D. Vargas et al.   ATHEROSCLEROSIS

Genomics is failing on diversity

(2016) Alice B. Popejoy et al.   NATURE

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

(2016) Georg B Ehret et al.   NATURE GENETICS

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

(2016) Thomas J Hoffmann et al.   NATURE GENETICS

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

(2016) David L Morris et al.   NATURE GENETICS

Detection of human adaptation during the past 2000 years

(2016) Yair Field et al.   SCIENCE

Using Genetic Distance to Infer the Accuracy of Genomic Prediction

(2016) Marco Scutari et al.   PLoS Genetics

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Sparse whole-genome sequencing identifies two loci for major depressive disorder

(2015) Na Cai et al.   NATURE

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Population genetic differentiation of height and body mass index across Europe

(2015) Matthew R Robinson et al.   NATURE GENETICS

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Large Scale Genetic Research on Neuropsychiatric Disorders in African Populations is Needed

(2015) Shareefa Dalvie et al.   EBioMedicine

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

(2014) Meian He et al.   HUMAN MOLECULAR GENETICS

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Defining the role of common variation in the genomic and biological architecture of adult human height

(2014) Andrew R Wood et al.   NATURE GENETICS

Regularized Machine Learning in the Genetic Prediction of Complex Traits

(2014) Sebastian Okser et al.   PLoS Genetics

A Population Genetic Signal of Polygenic Adaptation

(2014) Jeremy J. Berg et al.   PLoS Genetics

Pitfalls of predicting complex traits from SNPs

(2013) Naomi R. Wray et al.   NATURE REVIEWS GENETICS

Power and Predictive Accuracy of Polygenic Risk Scores

(2013) Frank Dudbridge   PLoS Genetics

Genomics for the world

(2011) Carlos D. Bustamante et al.   NATURE

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

(2009) Shaun M. Purcell et al.   NATURE

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS