The diverse origins of circulating cell-free DNA in the human body: a critical re-evaluation of the literature

Cell-free DNA in a three-dimensional spheroid cell culture model: A preliminary study

(2017) Janine Aucamp et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

New evidence that a large proportion of human blood plasma cell-free DNA is localized in exosomes

(2017) M. Rohan Fernando et al.   PLoS One

Characterization of the release and biological significance of cell-free DNA from breast cancer cell lines

(2017) Wei Wang et al.   Oncotarget

Characterization of the cell-free DNA released by cultured cancer cells

(2016) Abel Jacobus Bronkhorst et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Origins, structures, and functions of circulating DNA in oncology

(2016) A. R. Thierry et al.   CANCER AND METASTASIS REVIEWS

Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin

(2016) Matthew W. Snyder et al.   CELL

A historical and evolutionary perspective on the biological significance of circulating DNA and extracellular vesicles

(2016) Janine Aucamp et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cell-free DNA in maternal plasma and serum: A comparison of quantity, quality and tissue origin using genomic and epigenomic approaches

(2016) Felix C.K. Wong et al.   CLINICAL BIOCHEMISTRY

Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients

(2016) Kim Timmermans et al.   INTENSIVE CARE MEDICINE

Decreased Circulating mtDNA Levels in Professional Male Volleyball Players

(2016) Milena Nasi et al.   International Journal of Sports Physiology and Performance

Inferring expressed genes by whole-genome sequencing of plasma DNA

(2016) Peter Ulz et al.   NATURE GENETICS

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Identification of tissue-specific cell death using methylation patterns of circulating DNA

(2016) Roni Lehmann-Werman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Long and Short of Circulating Cell-Free DNA and the Ins and Outs of Molecular Diagnostics

(2016) Peiyong Jiang et al.   TRENDS IN GENETICS

Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance

(2016) S. Nishimoto et al.   Science Advances

Single-stranded DNA library preparation uncovers the origin and diversity of ultrashort cell-free DNA in plasma

(2016) Philip Burnham et al.   Scientific Reports

Very Short Mitochondrial DNA Fragments and Heteroplasmy in Human Plasma

(2016) Ruoyu Zhang et al.   Scientific Reports

Extracellular DNA: A Bridge to Cancer

(2015) M. C. Hawes et al.   CANCER RESEARCH

Cell-free DNA: Preanalytical variables

(2015) Abel Jacobus Bronkhorst et al.   CLINICA CHIMICA ACTA

Influence of storage conditions and extraction methods on the quantity and quality of circulating cell-free DNA (ccfDNA): the SPIDIA-DNAplas External Quality Assessment experience

(2015) Francesca Malentacchi et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Three-Dimensional Cell Culture: A Breakthrough in Vivo

(2015) Delphine Antoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Circulating nucleic acids damage DNA of healthy cells by integrating into their genomes

(2015) Indraneel Mittra et al.   JOURNAL OF BIOSCIENCES

Extracellular traps and macrophages: new roles for the versatile phagocyte

(2015) Devin M. Boe et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cell necrosis–independent sustained mitochondrial and nuclear DNA release following trauma surgery

(2015) Daniel J. McIlroy et al.   Journal of Trauma and Acute Care Surgery

Origin of Circulating Free DNA in Sepsis: Analysis of the CLP Mouse Model

(2015) Shigeto Hamaguchi et al.   MEDIATORS OF INFLAMMATION

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Noninvasive monitoring of infection and rejection after lung transplantation

(2015) Iwijn De Vlaminck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments

(2015) Kun Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-Free Fetal DNA, Telomeres, and the Spontaneous Onset of Parturition

(2015) Mark Phillippe   Reproductive Sciences

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

(2015) Valentina R. Minciacchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cell necrosis–independent sustained mitochondrial and nuclear DNA release following trauma surgery

(2015) Daniel J. McIlroy et al.   Journal of Trauma and Acute Care Surgery

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Exercise is a potent stimulus for enhancing circulating DNase activity

(2014) Martina Velders et al.   CLINICAL BIOCHEMISTRY

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with MutatedKRASandp53DNA in the Serum Exosomes of Patients with Pancreatic Cancer

(2014) Christoph Kahlert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Placental telomere length decreases with gestational age and is influenced by parity: A study of third trimester live-born twins

(2014) M. Gielen et al.   PLACENTA

Circulating nucleic acids: possible inherited effects

(2013) Peter Gahan   BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Circulating microparticles: square the circle

(2013) Natasha S Barteneva et al.   BMC CELL BIOLOGY

Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression

(2013) Inbal Mishalian et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Stressing the cell cycle in senescence and aging

(2013) Hollie Chandler et al.   CURRENT OPINION IN CELL BIOLOGY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Oxidized Extracellular DNA as a Stress Signal in Human Cells

(2013) Aleksei V. Ermakov et al.   Oxidative Medicine and Cellular Longevity

Review: Cell-free fetal DNA in the maternal circulation as an indication of placental health and disease

(2013) E.S. Taglauer et al.   PLACENTA

Complete Genes May Pass from Food to Human Blood

(2013) Sándor Spisák et al.   PLoS One

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

(2013) A. Hochreiter-Hufford et al.   Cold Spring Harbor Perspectives in Biology

Role of quantitative and qualitative characteristics of free circulating DNA in the management of patients with non-small cell lung cancer

(2013) Paola Ulivi et al.   CELLULAR ONCOLOGY

Autophagic removal of micronuclei

(2012) Santiago Rello-Varona et al.   CELL CYCLE

The origin and properties of extracellular DNA: From PAMP to DAMP

(2012) David S. Pisetsky   CLINICAL IMMUNOLOGY

Endoreplication and polyploidy: insights into development and disease

(2012) D. T. Fox et al.   DEVELOPMENT

Cell-free and cell-bound circulating nucleic acid complexes: mechanisms of generation, concentration and content

(2012) Elena Y Rykova et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

TLR9 Provokes Inflammation in Response to Fetal DNA: Mechanism for Fetal Loss in Preterm Birth and Preeclampsia

(2012) A. Scharfe-Nugent et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Short Fetal Leukocyte Telomere Length and Preterm Prelabor Rupture of the Membranes

(2012) Ramkumar Menon et al.   PLoS One

Cardiomyocyte Microvesicles Contain DNA/RNA and Convey Biological Messages to Target Cells

(2012) Anders Waldenström et al.   PLoS One

Circulating Cell-Free DNA

(2012) Sarah Breitbach et al.   SPORTS MEDICINE

Characterization of cell-free circulating DNA in plasma in patients with prostate cancer

(2012) Pâmela Oliveira Delgado et al.   TUMOR BIOLOGY

A Mechanism of Gene Amplification Driven by Small DNA Fragments

(2012) Kuntal Mukherjee et al.   PLoS Genetics

After trypsinisation, 3D spheroids of C3A hepatocytes need 18 days to re-establish similar levels of key physiological functions to those seen in the liver

(2012) Krzysztof Wrzesinski et al.   Toxicology Research

Oxidative stress and mitochondrial dysfunction in sepsis

(2011) H.F. Galley   BRITISH JOURNAL OF ANAESTHESIA

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

Controlled rereplication at DNA replication origins

(2011) María Gómez   CELL CYCLE

Origin, translocation and destination of extracellular occurring DNA — A new paradigm in genetic behaviour

(2011) Dimetrie L. Peters et al.   CLINICA CHIMICA ACTA

Short-Term Treadmill Running as a Model for Studying Cell-Free DNA Kinetics In Vivo

(2011) T. Beiter et al.   CLINICAL CHEMISTRY

Nonhematopoietically Derived DNA Is Shorter than Hematopoietically Derived DNA in Plasma: A Transplantation Model

(2011) Y. W. L. Zheng et al.   CLINICAL CHEMISTRY

An extracellular DNA mediated bystander effect produced from low dose irradiated endothelial cells

(2011) Aleksei V. Ermakov et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Formation of mammalian erythrocytes: chromatin condensation and enucleation

(2011) Peng Ji et al.   TRENDS IN CELL BIOLOGY

Prevention of DNA re-replication in eukaryotic cells

(2011) L. N. Truong et al.   Journal of Molecular Cell Biology

Erythroblast Enucleation

(2011) Ganesan Keerthivasan et al.   Stem Cells International

An Mg2+ and Ca2+-Stimulated Adenosine Triphosphatase in Human Prostatic Fluid - Part II*

(2010) G. RONQUIST et al.   ANDROLOGIA

Horizontal gene transfer: You are what you eat

(2010) Lars Holmgren   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell-Free Nucleic Acids Circulating in the Plasma of Colorectal Cancer Patients Induce the Oncogenic Transformation of Susceptible Cultured Cells

(2010) D. C. Garcia-Olmo et al.   CANCER RESEARCH

The virtosome-a novel cytosolic informative entity and intercellular messenger

(2010) Peter B. Gahan et al.   CELL BIOCHEMISTRY AND FUNCTION

Microparticles

(2010) Sebastian F. Mause et al.   CIRCULATION RESEARCH

DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia

(2010) Ryan KC Yuen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Aging is associated with quantitative and qualitative changes in circulating cell-free DNA: The Vitality 90+ study

(2010) Juulia Jylhävä et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Circulating nucleic acids in cancer and pregnancy

(2010) Pamela Pinzani et al.   METHODS

The ploidy conveyor of mature hepatocytes as a source of genetic variation

(2010) Andrew W. Duncan et al.   NATURE

Endoreplication: A Molecular Trick during Animal Neuron Evolution

(2010) Mauro Mandrioli et al.   QUARTERLY REVIEW OF BIOLOGY

Maternal Plasma DNA Sequencing Reveals the Genome-Wide Genetic and Mutational Profile of the Fetus

(2010) Y. M. D. Lo et al.   Science Translational Medicine

Microparticles in Cancer

(2010) Janusz Rak   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Promiscuous DNA: horizontal transfer of transposable elements and why it matters for eukaryotic evolution

(2010) Sarah Schaack et al.   TRENDS IN ECOLOGY & EVOLUTION

Circulating DNA

(2009) Maniesh van der Vaart et al.   Annals of the New York Academy of Sciences

Deoxyribonuclease Activity and Circulating DNA Concentration in Blood Plasma of Patients with Prostate Tumors

(2009) Anna V. Cherepanova et al.   Annals of the New York Academy of Sciences

The Effect of Protein Transport Inhibitors on the Production of Extracellular DNA

(2009) Evgeniy S. Morozkin et al.   Annals of the New York Academy of Sciences

Metabolic DNA as the Origin of Spontaneously Released DNA?

(2009) Peter B. Gahan et al.   Annals of the New York Academy of Sciences

A Method for Characterization of Total Circulating DNA

(2009) Maniesh van der Vaart et al.   Annals of the New York Academy of Sciences

Circulating mitochondrial DNA in the serum of patients with testicular germ cell cancer as a novel noninvasive diagnostic biomarker

(2009) Jörg Ellinger et al.   BJU INTERNATIONAL

Oncosome Formation in Prostate Cancer: Association with a Region of Frequent Chromosomal Deletion in Metastatic Disease

(2009) Dolores Di Vizio et al.   CANCER RESEARCH

Horizontal transfer of tumor DNA to endothelial cells in vivo

(2009) J Ehnfors et al.   CELL DEATH AND DIFFERENTIATION

Characterisation of circulating DNA by parallel tagged sequencing on the 454 platform

(2009) Maniesh van der Vaart et al.   CLINICA CHIMICA ACTA

Clinical use of circulating nucleosomes

(2009) Stefan Holdenrieder et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Endoreplication: polyploidy with purpose

(2009) H. O. Lee et al.   GENES & DEVELOPMENT

The clinical value of neutrophil extracellular traps

(2009) Tim Lögters et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence

(2009) Peter D. Adams   MOLECULAR CELL

Oxidative stress as a significant factor for development of an adaptive response in irradiated and nonirradiated human lymphocytes after inducing the bystander effect by low-dose X-radiation

(2009) Aleksei V. Ermakov et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Cip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy

(2009) Zakir Ullah et al.   Cell Division

Diagnosing Schistosomiasis by Detection of Cell-Free Parasite DNA in Human Plasma

(2009) Dominic Wichmann et al.   PLoS Neglected Tropical Diseases

The Inflammatory Response to Cell Death

(2008) Kenneth L. Rock et al.   Annual Review of Pathology-Mechanisms of Disease

Apoptosis and non-apoptotic deaths in cancer development and treatment response

(2008) Elza C. de Bruin et al.   CANCER TREATMENT REVIEWS

Death through a tragedy: mitotic catastrophe

(2008) H Vakifahmetoglu et al.   CELL DEATH AND DIFFERENTIATION

Cell-Free Plasma DNA as a Predictor of Outcome in Severe Sepsis and Septic Shock

(2008) K. Saukkonen et al.   CLINICAL CHEMISTRY

Size distribution of circulating cell-free DNA in sera of breast cancer patients in the course of adjuvant chemotherapy

(2008) Ugur Deligezer et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Effects of ultra-marathon on circulating DNA and mRNA expression of pro- and anti-apoptotic genes in mononuclear cells

(2008) Johanna Atamaniuk et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Overreplication of short DNA regions during S phase in human cells

(2008) M. Gomez et al.   GENES & DEVELOPMENT

NEUTROPHIL-DERIVED CIRCULATING FREE DNA (cf-DNA/NETs)

(2008) Stefan Margraf et al.   SHOCK

Characterization of circulating DNA in healthy human plasma

(2007) Nobuyasu Suzuki et al.   CLINICA CHIMICA ACTA