Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD

Inflammatory Bowel Disease 2017: Innovations and Changing Paradigms

(2017) Jean-Frederic Colombel et al.   GASTROENTEROLOGY

MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

(2017) G-T Ho et al.   Mucosal Immunology

Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome

(2017) David A Dorward et al.   THORAX

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical Effects of a Topically Applied Toll-like Receptor 9 Agonist in Active Moderate-to-Severe Ulcerative Colitis

(2016) Raja Atreya et al.   Journal of Crohns & Colitis

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications

(2016) R K Boyapati et al.   Mucosal Immunology

The Role of Formylated Peptides and Formyl Peptide Receptor 1 in Governing Neutrophil Function during Acute Inflammation

(2015) David A. Dorward et al.   AMERICAN JOURNAL OF PATHOLOGY

Cationic nanocarriers induce cell necrosis through impairment of Na+/K+-ATPase and cause subsequent inflammatory response

(2015) Xiawei Wei et al.   CELL RESEARCH

Role of Mitochondrial DNA in Septic AKI via Toll-Like Receptor 9

(2015) N. Tsuji et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TLR9 Mediates Remote Liver Injury following Severe Renal Ischemia Reperfusion

(2015) Pieter J. Bakker et al.   PLoS One

Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome

(2014) Mitchell R. McGill et al.   HEPATOLOGY

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

(2014) Kiichi Nakahira et al.   PLOS MEDICINE

Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation

(2013) Bo Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure

(2012) Pedro E. Marques et al.   HEPATOLOGY

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Mitochondrial disorders as windows into an ancient organelle

(2012) Scott B. Vafai et al.   NATURE

TLR9 is important for protection against intestinal damage and for intestinal repair

(2012) William Alfred Rose II et al.   Scientific Reports

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL