Cell-Free Nucleic Acids and their Emerging Role in the Pathogenesis and Clinical Management of Inflammatory Bowel Disease

Exosomes: biogenesis, biologic function and clinical potential

(2019) Yuan Zhang et al.   Cell and Bioscience

Liquid biopsy and minimal residual disease — latest advances and implications for cure

(2019) Klaus Pantel et al.   Nature Reviews Clinical Oncology

Neutrophil Extracellular Traps Sustain Inflammatory Signals in Ulcerative Colitis

(2019) Vincenzo Dinallo et al.   Journal of Crohns & Colitis

Circulating lncRNA ITSN1-2 is upregulated, and its high expression correlates with increased disease severity, elevated inflammation, and poor survival in sepsis patients

(2019) Qingwei Zeng et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Circulating microRNA146b-5p is superior to C-reactive protein as a novel biomarker for monitoring inflammatory bowel disease

(2019) Peng Chen et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Mo1119 – The Role of Extracellular Dna in the Pathogenesis of Dss-Induced Colitis in Mice

(2019) Roman Gardlik et al.   GASTROENTEROLOGY

Metaproteomics of fecal samples of Crohn's disease and Ulcerative Colitis

(2019) T. Lehmann et al.   Journal of Proteomics

Exosome-Induced Regulation in Inflammatory Bowel Disease

(2019) Huiting Zhang et al.   Frontiers in Immunology

Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD

(2018) Ray K Boyapati et al.   INFLAMMATORY BOWEL DISEASES

Circulating and Fecal microRNAs as Biomarkers for Inflammatory Bowel Diseases

(2018) Katharina Schönauen et al.   INFLAMMATORY BOWEL DISEASES

Circulating lncRNA IFNG-AS1 expression correlates with increased disease risk, higher disease severity and elevated inflammation in patients with coronary artery disease

(2018) Yahuan Xu et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

REDD1/Autophagy Pathway Is Associated with Neutrophil-Driven IL-1β Inflammatory Response in Active Ulcerative Colitis

(2018) Iliana Angelidou et al.   JOURNAL OF IMMUNOLOGY

Peripheral whole blood lncRNA expression analysis in patients with eosinophilic asthma

(2018) Yu-Jin Zhu et al.   MEDICINE

Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system

(2018) Masaki Honda et al.   Nature Reviews Gastroenterology & Hepatology

The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases

(2018) Luca Liberale et al.   THROMBOSIS AND HAEMOSTASIS

Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease

(2018) Xu Zhang et al.   Nature Communications

Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease

(2018) Ahmed Moustafa et al.   Clinical and Translational Gastroenterology

Hookworm Secreted Extracellular Vesicles Interact With Host Cells and Prevent Inducible Colitis in Mice

(2018) Ramon M. Eichenberger et al.   Frontiers in Immunology

Neutrophil extracellular traps in pediatric inflammatory bowel disease

(2018) Yehonatan Gottlieb et al.   PATHOLOGY INTERNATIONAL

Exosomes in inflammation and role as biomarkers

(2018) Lara Console et al.   CLINICA CHIMICA ACTA

Exosomes as a novel cell‐free therapeutic approach in gastrointestinal diseases

(2018) Kaveh Baghaei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer

(2017) Ludovic Barault et al.   GUT

Plasma microRNA Profile Differentiates Crohn’s Colitis From Ulcerative Colitis

(2017) Uri Netz et al.   INFLAMMATORY BOWEL DISEASES

P055 Mitochondrial DNA is a damage-associated molecular pattern released during active IBD promoting TLR9-mediated inflammation

(2017) R. Boyapati et al.   Journal of Crohns & Colitis

Host DNases prevent vascular occlusion by neutrophil extracellular traps

(2017) Miguel Jiménez-Alcázar et al.   SCIENCE

The long non-coding RNA NEAT1 enhances epithelial-to-mesenchymal transition and chemoresistance via the miR-34a/c-Met axis in renal cell carcinoma

(2017) Fei Liu et al.   Oncotarget

Serum miRNA signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans

(2017) Emilie Viennois et al.   Scientific Reports

Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease

(2017) Xiaowen Zheng et al.   Protein & Cell

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Inflammatory Bowel Disease in Mice

(2017) Fei Mao et al.   Biomed Research International

Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview

(2017) Vidal Delgado-Rizo et al.   Frontiers in Immunology

Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies

(2017) Duk Hwan Kim et al.   Immune Network

Circulating mRNAs and miRNAs as candidate markers for the diagnosis and prognosis of prostate cancer

(2017) Marilesia Ferreira de Souza et al.   PLoS One

The dark side of circulating nucleic acids

(2016) Silvia Gravina et al.   AGING CELL

A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation

(2016) David Padua et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Sources and Functions of Extracellular Small RNAs in Human Circulation

(2016) Joëlle V. Fritz et al.   Annual Review of Nutrition

Cell Free DNA and Procalcitonin as Early Markers of Complications in ICU Patients with Multiple Trauma and Major Surgery

(2016) Asmaa Ahmed et al.   Clinical Laboratory

Identification of Circulating MicroRNA Signatures in Crohnʼs Disease Using the Nanostring nCounter Technology

(2016) Angelos Oikonomopoulos et al.   INFLAMMATORY BOWEL DISEASES

Exosomes Released from Cells Infected with Crohnʼs Disease–associated Adherent-Invasive Escherichia coli Activate Host Innate Immune Responses and Enhance Bacterial Intracellular Replication

(2016) Jessica Carrière et al.   INFLAMMATORY BOWEL DISEASES

Luminal Extracellular Vesicles (EVs) in Inflammatory Bowel Disease (IBD) Exhibit Proinflammatory Effects on Epithelial Cells and Macrophages

(2016) Shuji Mitsuhashi et al.   INFLAMMATORY BOWEL DISEASES

MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions

(2016) Caterina Catalanotto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circulating MicroRNA223 is a New Biomarker for Inflammatory Bowel Disease

(2016) Huiling Wang et al.   MEDICINE

Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications

(2016) R K Boyapati et al.   Mucosal Immunology

Proteomic profiling of dextran sulfate sodium induced acute ulcerative colitis mice serum exosomes and their immunomodulatory impact on macrophages

(2016) Wing-Yan Wong et al.   PROTEOMICS

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

(2016) J. Park et al.   Science Translational Medicine

Phosphotidylserine exposure and neutrophil extracellular traps enhance procoagulant activity in patients with inflammatory bowel disease

(2016) Ruishuang Ma et al.   THROMBOSIS AND HAEMOSTASIS

Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment

(2016) Jordan E Axelrad et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Plasma long noncoding RNA expression profile identified by microarray in patients with Crohn’s disease

(2016) Dong Chen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance

(2016) Lingling Jiang et al.   Nature Communications

Cell-free circulating mitochondrial DNA content and risk of hepatocellular carcinoma in patients with chronic HBV infection

(2016) Ling Li et al.   Scientific Reports

Single-stranded DNA library preparation uncovers the origin and diversity of ultrashort cell-free DNA in plasma

(2016) Philip Burnham et al.   Scientific Reports

The Role of Cell-Free Plasma DNA in Critically Ill Patients with Sepsis

(2015) Anna Clementi et al.   BLOOD PURIFICATION

Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases

(2015) Thanh-Huyen Tran et al.   CLINICAL IMMUNOLOGY

Circulating microRNAs as biomarkers of adult Crohn’s disease

(2015) Michael D. Jensen et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Circulating cell-free mitochondrial DNA as the probable inducer of early endothelial dysfunction in the prediabetic patient

(2015) Noé Alvarado-Vásquez   EXPERIMENTAL GERONTOLOGY

Overexpression of miR-595 and miR-1246 in the Sera of Patients with Active Forms of Inflammatory Bowel Disease

(2015) Geoffrey W. Krissansen et al.   INFLAMMATORY BOWEL DISEASES

Assessment of Circulating MicroRNAs for the Diagnosis and Disease Activity Evaluation in Patients with Ulcerative Colitis by Using the Nanostring Technology

(2015) Christos Polytarchou et al.   INFLAMMATORY BOWEL DISEASES

Neutrophil Extracellular Traps in Ulcerative Colitis

(2015) Tue Bjerg Bennike et al.   INFLAMMATORY BOWEL DISEASES

Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair

(2015) Giovanna Leoni et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating cell-free mitochondrial deoxyribonucleic acid is increased in coronary heart disease patients with diabetes mellitus

(2015) Jing Liu et al.   Journal of Diabetes Investigation

The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense

(2015) Shuiqing Hu et al.   Cell Reports

Excretion of Host DNA in Feces Is Associated with Risk ofClostridium difficileInfection

(2015) Caroline Vincent et al.   Journal of Immunology Research

Preconditioning with Intravenous Colitic Cell-Free DNA Prevents DSS-Colitis by Altering TLR9-Associated Gene Expression Profile

(2014) Györgyi Műzes et al.   DIGESTIVE DISEASES AND SCIENCES

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

(2014) A. Sugiura et al.   EMBO JOURNAL

Probiotic Lactobacillus rhamnosus Inhibits the Formation of Neutrophil Extracellular Traps

(2014) L. Vong et al.   JOURNAL OF IMMUNOLOGY

Intravenous Administration of a Single-Dose Free-Circulating DNA of Colitic Origin Improves Severe Murine DSS-Colitis

(2014) Ferenc Sipos et al.   PATHOLOGY & ONCOLOGY RESEARCH

Dynamic pathology for circulating free DNA in a dextran sodium sulfate colitis mouse model

(2014) Yuhki Koike et al.   PEDIATRIC SURGERY INTERNATIONAL

Effects of GWAS-Associated Genetic Variants on lncRNAs within IBD and T1D Candidate Loci

(2014) Aashiq H. Mirza et al.   PLoS One

Cell-free nucleic acids as noninvasive biomarkers for colorectal cancer detection

(2014) Hicham Mansour   Frontiers in Genetics

PR3-ANCA: A promising biomarker for ulcerative colitis with extensive disease

(2013) Michael Mahler et al.   CLINICA CHIMICA ACTA

Histone Methyltransferase Ash1l Suppresses Interleukin-6 Production and Inflammatory Autoimmune Diseases by Inducing the Ubiquitin-Editing Enzyme A20

(2013) Meng Xia et al.   IMMUNITY

Non-invasive prenatal diagnosis from the perspective of a low-resource country

(2013) Walter Ventura et al.   INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies

(2012) T. A. Fuchs et al.   BLOOD

Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity

(2012) S. Sangaletti et al.   BLOOD

The importance of examining the proportion of circulating DNA originating from tumor, microenvironment and normal cells in colorectal cancer patients

(2012) Florent Mouliere et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression

(2012) T. Derrien et al.   GENOME RESEARCH

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Circulating MicroRNA in inflammatory bowel disease

(2012) Archanioti Paraskevi et al.   Journal of Crohns & Colitis

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes

(2012) Alessia Gallo et al.   PLoS One

Genome-Wide Maps of Circulating miRNA Biomarkers for Ulcerative Colitis

(2012) Radha Duttagupta et al.   PLoS One

MicroRNAs in inflammatory bowel disease - pathogenesis, diagnostics and therapeutics

(2012) Mehmet Coskun   WORLD JOURNAL OF GASTROENTEROLOGY

TLR9 is important for protection against intestinal damage and for intestinal repair

(2012) William Alfred Rose II et al.   Scientific Reports

Recovering circulating extracellular or cell-free RNA from bodily fluids

(2011) Georgios Tzimagiorgis et al.   Cancer Epidemiology

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Circulating MicroRNA Is a Biomarker of Pediatric Crohn Disease

(2011) Adam M Zahm et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Innate Immune Sensing of DNA

(2011) Shruti Sharma et al.   PLoS Pathogens

The MicroRNA Spectrum in 12 Body Fluids

(2010) J. A. Weber et al.   CLINICAL CHEMISTRY

Peripheral blood MicroRNAs distinguish active ulcerative colitis and Crohnʼs disease

(2010) Feng Wu et al.   INFLAMMATORY BOWEL DISEASES

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease

(2010) Jean Frédéric Colombel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Overview of Circulating Nucleic Acids in Plasma/Serum

(2009) Asif N. Butt et al.   Annals of the New York Academy of Sciences

Evolution and Functions of Long Noncoding RNAs

(2009) Chris P. Ponting et al.   CELL

Long non-coding RNAs: insights into functions

(2009) Tim R. Mercer et al.   NATURE REVIEWS GENETICS

DNase 1 and systemic lupus erythematosus

(2008) Fernando Martínez Valle et al.   AUTOIMMUNITY REVIEWS

Toll-like receptors control autophagy

(2008) Mónica A Delgado et al.   EMBO JOURNAL

MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death

(2008) R Schickel et al.   ONCOGENE