Microfluidic and Organ-on-a-Chip Approaches to Investigate Cellular and Microenvironmental Contributions to Cardiovascular Function and Pathology

Microfluidics for the study of mechanotransduction

(2020) Christian M Griffith et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome

(2020) Leigh Atchison et al.   Stem Cell Reports

Tortuosity-powered microfluidic device for assessment of thrombosis and antithrombotic therapy in whole blood

(2020) David J. Luna et al.   Scientific Reports

A tissue-engineered 3D microvessel model reveals the dynamics of mosaic vessel formation in breast cancer

(2020) Vanesa L. Silvestri et al.   CANCER RESEARCH

Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform

(2020) Matthew L. Kutys et al.   Nature Communications

The Ehlers–Danlos syndromes

(2020) Fransiska Malfait et al.   Nature Reviews Disease Primers

Organs-on-chips: into the next decade

(2020) Lucie A. Low et al.   NATURE REVIEWS DRUG DISCOVERY

Microfabricated blood vessels for modeling the vascular transport barrier

(2019) William J. Polacheck et al.   Nature Protocols

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

Atherosclerosis

(2019) Peter Libby et al.   Nature Reviews Disease Primers

Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels

(2019) Mark A. Skylar-Scott et al.   Science Advances

Using microfluidic devices to study thrombosis in pathological blood flows

(2018) Bradley A. Herbig et al.   Biomicrofluidics

Diabetes and aortic aneurysm: current state of the art

(2018) Juliette Raffort et al.   CARDIOVASCULAR RESEARCH

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Hydrodynamics in Cell Studies

(2018) Deborah Huber et al.   CHEMICAL REVIEWS

Functional polymer surfaces for controlling cell behaviors

(2018) Lina Chen et al.   Materials Today

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

(2018) Kacey Ronaldson-Bouchard et al.   NATURE

Fibrillin microfibrils and elastic fibre proteins: Functional interactions and extracellular regulation of growth factors

(2018) Jennifer Thomson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Heart on a chip: Micro-nanofabrication and microfluidics steering the future of cardiac tissue engineering

(2018) Maria Kitsara et al.   MICROELECTRONIC ENGINEERING

A patient-specific intracranial aneurysm model with endothelial lining: a novel in vitro approach to bridge the gap between biology and flow dynamics

(2017) Naoki Kaneko et al.   Journal of NeuroInterventional Surgery

Inhibition of α v β 5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury

(2017) Amy McCurley et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

(2017) Pedro F. Costa et al.   LAB ON A CHIP

Biomaterial stiffness determines stem cell fate

(2017) Hongwei Lv et al.   LIFE SCIENCES

Microfluidic approaches to the study of angiogenesis and the microcirculation

(2017) Ehsan Akbari et al.   MICROCIRCULATION

A non-canonical Notch complex regulates adherens junctions and vascular barrier function

(2017) William J. Polacheck et al.   NATURE

Vascular heterogeneity and specialization in development and disease

(2017) Michael Potente et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Application of microfluidic devices in studies of thrombosis and hemostasis

(2017) Changjie Zhang et al.   PLATELETS

Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model

(2017) João Ribas et al.   Small

Matrix degradability controls multicellularity of 3D cell migration

(2017) Britta Trappmann et al.   Nature Communications

A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells

(2017) Leigh Atchison et al.   Scientific Reports

Age-related Impairment of Vascular Structure and Functions

(2017) Xianglai Xu et al.   Aging and Disease

In vitro cardiac tissue models: Current status and future prospects

(2016) Anurag Mathur et al.   ADVANCED DRUG DELIVERY REVIEWS

In microfluidico: Recreating in vivo hemodynamics using miniaturized devices

(2016) Shu Zhu et al.   BIORHEOLOGY

FBN1 : The disease-causing gene for Marfan syndrome and other genetic disorders

(2016) Lynn Y. Sakai et al.   GENE

Loss-of-function mutations in the X-linked biglycan gene cause a severe syndromic form of thoracic aortic aneurysms and dissections

(2016) Josephina A.N. Meester et al.   GENETICS IN MEDICINE

Characteristic adaptations of the extracellular matrix in dilated cardiomyopathy

(2016) Laura Louzao-Martinez et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues

(2016) Anna Marsano et al.   LAB ON A CHIP

3D cardiac μtissues within a microfluidic device with real-time contractile stress readout

(2016) Aereas Aung et al.   LAB ON A CHIP

Biomimetic 4D printing

(2016) A. Sydney Gladman et al.   NATURE MATERIALS

Measuring cell-generated forces: a guide to the available tools

(2016) William J Polacheck et al.   NATURE METHODS

Matrix stiffening promotes a tumor vasculature phenotype

(2016) Francois Bordeleau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Early-Stage Atherosclerosis Research Model Based on Microfluidics

(2016) Wenfu Zheng et al.   Small

On-chip assessment of human primary cardiac fibroblasts proliferative responses to uniaxial cyclic mechanical strain

(2015) Giovanni Stefano Ugolini et al.   BIOTECHNOLOGY AND BIOENGINEERING

Evaluation of aneurysm-associated wall shear stress related to morphological variations of circle of Willis using a microfluidic device

(2015) Seong-Won Nam et al.   JOURNAL OF BIOMECHANICS

3D printed microfluidics for biological applications

(2015) Chee Meng Benjamin Ho et al.   LAB ON A CHIP

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

(2015) J. T. Hinson et al.   SCIENCE

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease

(2015) Angharad M. Roberts et al.   Science Translational Medicine

“Do-it-yourself in vitro vasculature that recapitulates in vivo geometries for investigating endothelial-blood cell interactions”

(2015) Robert G. Mannino et al.   Scientific Reports

Myocardial Extracellular Matrix

(2014) Marieke Rienks et al.   CIRCULATION RESEARCH

The Vascular Endothelium and Human Diseases

(2014) Peramaiyan Rajendran et al.   International Journal of Biological Sciences

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

(2014) Gang Wang et al.   NATURE MEDICINE

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Flow shear stress regulates endothelial barrier function and expression of angiogenic factors in a 3D microfluidic tumor vascular model

(2014) Cara F Buchanan et al.   Cell Adhesion & Migration

Treatment of Vascular Ehlers-Danlos Syndrome

(2013) David Bergqvist et al.   ANNALS OF SURGERY

ECM-modulated cellular dynamics as a driving force for tissue morphogenesis

(2013) William P Daley et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Physicochemical regulation of endothelial sprouting in a 3D microfluidic angiogenesis model

(2013) Scott S. Verbridge et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Microfluidic platforms for mechanobiology

(2013) William J. Polacheck et al.   LAB ON A CHIP

Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device

(2013) Andries D. van der Meer et al.   LAB ON A CHIP

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle

(2013) Yun Xiao et al.   LAB ON A CHIP

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

(2013) Erik Westein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

(2013) D.-H. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and formulation of functional pluripotent stem cell-derived cardiac microtissues

(2013) N. Thavandiran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfluidic Models of Vascular Functions

(2012) Keith H.K. Wong et al.   Annual Review of Biomedical Engineering

Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels

(2012) Lauren L. Bischel et al.   BIOMATERIALS

Extracellular matrix and the mechanics of large artery development

(2012) Jeffrey K. Cheng et al.   Biomechanics and Modeling in Mechanobiology

Twisted Blood Vessels: Symptoms, Etiology and Biomechanical Mechanisms

(2012) Hai-Chao Han   JOURNAL OF VASCULAR RESEARCH

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Truncations of Titin Causing Dilated Cardiomyopathy

(2012) Daniel S. Herman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Elastin in Large Artery Stiffness and Hypertension

(2012) Jessica E. Wagenseil et al.   Journal of Cardiovascular Translational Research

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology

(2011) Michelle Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients

(2011) Yoojin Shin et al.   LAB ON A CHIP

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

Fluid forces control endothelial sprouting

(2011) J. W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Microfabricated Platform to Measure and Manipulate the Mechanics of Engineered Cardiac Microtissues

(2011) Thomas Boudou et al.   TISSUE ENGINEERING PART A

Cardiac Titin

(2010) Martin M. LeWinter et al.   CIRCULATION

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Differentiation of cardiomyocytes from human embryonic stem cells is accompanied by changes in the extracellular matrix production of versican and hyaluronan

(2010) Christina K. Chan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Hemodynamic–Morphologic Discriminants for Intracranial Aneurysm Rupture

(2010) Jianping Xiang et al.   STROKE

Collagen-Based Biomaterials for Tissue Engineering Applications

(2010) Rémi Parenteau-Bareil et al.   Materials

The enigmatic role of tafazzin in cardiolipin metabolism

(2009) Riekelt H. Houtkooper et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Recent developments in PDMS surface modification for microfluidic devices

(2009) Jinwen Zhou et al.   ELECTROPHORESIS

A Framework for Geometric Analysis of Vascular Structures: Application to Cerebral Aneurysms

(2009) M. Piccinelli et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Vascular Extracellular Matrix and Arterial Mechanics

(2009) Jessica E. Wagenseil et al.   PHYSIOLOGICAL REVIEWS

Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues

(2009) W. R. Legant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA