Human RecQ Helicases in DNA Double-Strand Break Repair

V(D)J recombination, somatic hypermutation and class switch recombination of immunoglobulins: mechanism and regulation

(2020) Xiying Chi et al.   IMMUNOLOGY

Human RPA activates BLM's bidirectional DNA unwinding from a nick

(2020) Zhenheng Qin et al.   eLife

RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription

(2020) Martin Andrs et al.   Genes

DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP

(2020) Rajashree A. Deshpande et al.   Science Advances

Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

(2020) Shunlei Duan et al.   NUCLEIC ACIDS RESEARCH

WRN-Mutated Colorectal Cancer Is Characterized by a Distinct Genetic Phenotype

(2020) Kai Zimmer et al.   Cancers

Exploiting the Microhomology-Mediated End-Joining Pathway in Cancer Therapy

(2020) Jeffrey Patterson-Fortin et al.   CANCER RESEARCH

MIB1-mediated degradation of WRN promotes cellular senescence in response to camptothecin treatment

(2020) Meiting Li et al.   FASEB JOURNAL

RECQ1 Helicase in Genomic Stability and Cancer

(2020) Subrata Debnath et al.   Genes

Mutations in conserved functional domains of human RecQ helicases are associated with diseases and cancer: A review

(2020) Aditya Mojumdar   BIOPHYSICAL CHEMISTRY

Repeat expansions confer WRN dependence in microsatellite-unstable cancers

(2020) Niek van Wietmarschen et al.   NATURE

Limiting the DNA Double-Strand Break Resectosome for Genome Protection

(2020) Daryl A. Ronato et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients

(2020) Lauren G. Aoude et al.   Scientific Reports

RPA Phosphorylation Inhibits DNA Resection

(2019) Michael M. Soniat et al.   MOLECULAR CELL

WRN helicase is a synthetic lethal target in microsatellite unstable cancers

(2019) Edmond M. Chan et al.   NATURE

Oral squamous cell carcinoma arising in a patient with Werner syndrome

(2019) N. Kuribayashi et al.   INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

DNA double-strand break repair-pathway choice in somatic mammalian cells

(2019) Ralph Scully et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single-molecule visualization of human BLM helicase as it acts upon double- and single-stranded DNA substrates

(2019) Chaoyou Xue et al.   NUCLEIC ACIDS RESEARCH

DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response

(2019) Huiming Lu et al.   NUCLEIC ACIDS RESEARCH

Chromosome instability syndromes

(2019) A. Malcolm R. Taylor et al.   Nature Reviews Disease Primers

Mutation Spectrum of Cancer-Associated Genes in Patients With Early Onset of Colorectal Cancer

(2019) Gulnur Zhunussova et al.   Frontiers in Oncology

Human RECQL4 represses the RAD52‐mediated single‐strand annealing pathway after ionizing radiation or cisplatin treatment

(2019) Masaoki Kohzaki et al.   INTERNATIONAL JOURNAL OF CANCER

The DNA repair helicase RECQ1 has a checkpoint-dependent role in mediating DNA damage responses induced by gemcitabine

(2019) Swetha Parvathaneni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Germline BLM mutations and metastatic prostate cancer

(2019) Elisa M. Ledet et al.   PROSTATE

Non-enzymatic roles of human RAD51 at stalled replication forks

(2019) Jennifer M. Mason et al.   Nature Communications

Werner syndrome ( WRN ) gene variants and their association with altered function and age-associated diseases

(2018) Michel Lebel et al.   AGEING RESEARCH REVIEWS

Assessment of DNA repair susceptibility genes identified by whole exome sequencing in head and neck cancer

(2018) Raima Das et al.   DNA REPAIR

Rare missense mutations in RECQL and POLG associate with inherited predisposition to breast cancer

(2018) Anna Tervasmäki et al.   INTERNATIONAL JOURNAL OF CANCER

Repair of DNA double-strand breaks by mammalian alternative end-joining pathways

(2018) Annahita Sallmyr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homologous recombination and the repair of DNA double-strand breaks

(2018) William Douglass Wright et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting

(2018) Junko Oshima et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Multiple RPAs make WRN syndrome protein a superhelicase

(2018) Mina Lee et al.   NUCLEIC ACIDS RESEARCH

CASP8, XRCC1, WRN, NF2, and BRIP1 Polymorphisms Analysis Shows Their Genetic Susceptibility for Meningioma Risk and the Association with Tumor-Related Phenotype in a Chinese Population

(2018) Guanyou Huang et al.   World Neurosurgery

Targeted next generation sequencing identifies functionally deleterious germline mutations in novel genes in early-onset/familial prostate cancer

(2018) Paula Paulo et al.   PLoS Genetics

SHLD2/FAM35A co‐operates with REV7 to coordinate DNA double‐strand break repair pathway choice

(2018) Steven Findlay et al.   EMBO JOURNAL

Werner Syndrome Protein and DNA Replication

(2018) Shibani Mukherjee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

15 years of PhosphoSitePlus®: integrating post-translationally modified sites, disease variants and isoforms

(2018) Peter V Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Endogenous DNA Double-Strand Breaks during DNA Transactions: Emerging Insights and Methods for Genome-Wide Profiling

(2018) Britta A. M. Bouwman et al.   Genes

Hotspots for Initiation of Meiotic Recombination

(2018) Andrew J. Tock et al.   Frontiers in Genetics

A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation

(2017) Jing Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonhomologous DNA end-joining for repair of DNA double-strand breaks

(2017) Nicholas R. Pannunzio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites

(2017) Dharm S. Patel et al.   JOURNAL OF CELL BIOLOGY

The control of DNA repair by the cell cycle

(2017) Nicole Hustedt et al.   NATURE CELL BIOLOGY

WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1

(2017) Luxi Sun et al.   NUCLEIC ACIDS RESEARCH

Yeast Hrq1 shares structural and functional homology with the disease-linked human RecQ4 helicase

(2017) Cody M. Rogers et al.   NUCLEIC ACIDS RESEARCH

FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres

(2017) Xiaolei Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism

(2017) Sebastian Kaiser et al.   Nature Communications

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair

(2017) Huiming Lu et al.   Nature Communications

Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma—an aggressive and fatal disease

(2017) Anja Stirnweiss et al.   Oncotarget

Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP

(2017) James M. Daley et al.   Cell Reports

Germline RECQL mutations in high risk Chinese breast cancer patients

(2016) Ava Kwong et al.   BREAST CANCER RESEARCH AND TREATMENT

RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins

(2016) Prabhat Khadka et al.   DNA REPAIR

Do DNA Double-Strand Breaks Drive Aging?

(2016) Ryan R. White et al.   MOLECULAR CELL

WRN, the Werner Syndrome Gene, Exhibits Frameshift Mutations in Gastric and Colorectal Cancers

(2016) Ju Hwa Lee et al.   PATHOLOGY & ONCOLOGY RESEARCH

Analysis of DNA Repair Genes Polymorphisms in Breast Cancer

(2016) Hanna Romanowicz et al.   PATHOLOGY & ONCOLOGY RESEARCH

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

Regulation of Single-Strand Annealing and its Role in Genome Maintenance

(2016) Ragini Bhargava et al.   TRENDS IN GENETICS

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins

(2016) Gabrielle J. Grundy et al.   Nature Communications

CDK1 phosphorylates WRN at collapsed replication forks

(2016) Valentina Palermo et al.   Nature Communications

Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer

(2016) Raghavendra A. Shamanna et al.   Oncotarget

RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

(2016) Huiming Lu et al.   Cell Reports

Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases

(2016) Cosimo Pinto et al.   eLife

DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities

(2016) Takashi Tadokoro et al.   Aging-US

Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks

(2016) Rika Kusumoto-Matsuo et al.   Aging-US

Catalytic Strand Separation by RECQ1 Is Required for RPA-Mediated Response to Replication Stress

(2015) Taraswi Banerjee et al.   CURRENT BIOLOGY

Single nucleotide polymorphism in the RECQL5 gene increased osteosarcoma susceptibility in a Chinese Han population

(2015) Y.Z. Dong et al.   GENETICS AND MOLECULAR RESEARCH

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

(2015) William C. Drosopoulos et al.   JOURNAL OF CELL BIOLOGY

Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities

(2015) Prabhat Khadka et al.   MOLECULAR AND CELLULAR BIOLOGY

Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry

(2015) Weixing Zhao et al.   MOLECULAR CELL

The Ku heterodimer: Function in DNA repair and beyond

(2015) Victoria L. Fell et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Germline RECQL mutations are associated with breast cancer susceptibility

(2015) Cezary Cybulski et al.   NATURE GENETICS

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

(2015) Joseph A. Newman et al.   NUCLEIC ACIDS RESEARCH

Methylation of Werner syndrome protein is associated with the occurrence and development of invasive meningioma via the regulation of Myc and p53 expression

(2015) PUXIAN LI et al.   Experimental and Therapeutic Medicine

Deleterious Germline BLM Mutations and the Risk for Early-onset Colorectal Cancer

(2015) Richarda M. de Voer et al.   Scientific Reports

Mutations in RECQL Gene Are Associated with Predisposition to Breast Cancer

(2015) Jie Sun et al.   PLoS Genetics

DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining

(2015) Sean M. Howard et al.   PLoS Genetics

The Extraintestinal Pathogenic Escherichia coli Factor RqlI Constrains the Genotoxic Effects of the RecQ-Like Helicase RqlH

(2015) Colin W. Russell et al.   PLoS Pathogens

Human RecQ Helicases in DNA Repair, Recombination, and Replication

(2014) Deborah L. Croteau et al.   Annual Review of Biochemistry

RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex

(2014) Raghavendra A. Shamanna et al.   CARCINOGENESIS

RECQL5 Controls Transcript Elongation and Suppresses Genome Instability Associated with Transcription Stress

(2014) Marco Saponaro et al.   CELL

DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

(2014) Anthony J. Davis et al.   DNA REPAIR

DNA2 Cooperates with the WRN and BLM RecQ Helicases to Mediate Long-range DNA End Resection in Human Cells

(2014) Andreas Sturzenegger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Werner syndrome protein positively regulates XRCC4-like factor transcription

(2014) DONGYUN LIU et al.   Molecular Medicine Reports

Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks

(2014) Elda Cannavo et al.   NATURE

Human RECQL1 participates in telomere maintenance

(2014) Venkateswarlu Popuri et al.   NUCLEIC ACIDS RESEARCH

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Association between RECQL5 genetic polymorphisms and susceptibility to breast cancer

(2014) Yu-Jun He et al.   TUMOR BIOLOGY

End Resection at Double-Strand Breaks: Mechanism and Regulation

(2014) L. S. Symington   Cold Spring Harbor Perspectives in Biology

Senescence induced by RECQL4 dysfunction contributes to Rothmund–Thomson syndrome features in mice

(2014) H Lu et al.   Cell Death & Disease

Hrq1, a Homolog of the Human RecQ4 Helicase, Acts Catalytically and Structurally to Promote Genome Integrity

(2014) Matthew L. Bochman et al.   Cell Reports

The BLM dissolvasome in DNA replication and repair

(2013) Kelly A. Manthei et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hrq1 functions independently of Sgs1 to preserve genome integrity in Saccharomyces cerevisiae

(2013) Do-Hee Choi et al.   JOURNAL OF MICROBIOLOGY

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

(2013) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing

(2013) Shreya Paliwal et al.   NUCLEIC ACIDS RESEARCH

Spectrum and Risk of Neoplasia in Werner Syndrome: A Systematic Review

(2013) Julia M. Lauper et al.   PLoS One

Human RECQ1 Interacts with Ku70/80 and Modulates DNA End-Joining of Double-Strand Breaks

(2013) Swetha Parvathaneni et al.   PLoS One

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

(2013) L. N. Truong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population

(2013) Li-Qiang Zhi et al.   TUMOR BIOLOGY

A Role for BLM in Double-Strand Break Repair Pathway Choice: Prevention of CtIP/Mre11-Mediated Alternative Nonhomologous End-Joining

(2013) Anastazja Grabarz et al.   Cell Reports

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

(2012) Deborah L. Croteau et al.   AGING CELL

The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation

(2012) Masaoki Kohzaki et al.   CARCINOGENESIS

RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures

(2012) Venkateswarlu Popuri et al.   CELL CYCLE

RECQ1 plays a distinct role in cellular response to oxidative DNA damage

(2012) Sudha Sharma et al.   DNA REPAIR

Recruitment and retention dynamics of RECQL5 at DNA double strand break sites

(2012) Venkateswarlu Popuri et al.   DNA REPAIR

Clinical utility gene card for: Rothmund–Thomson syndrome

(2012) Lidia Larizza et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Polarity and Bypass of DNA Heterology during Branch Migration of Holliday Junctions by Human RAD54, BLM, and RECQ1 Proteins

(2012) Olga M. Mazina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Collaborating functions of BLM and DNA topoisomerase I in regulating human rDNA transcription

(2012) Patrick M. Grierson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability

(2012) Dharmendra Kumar Singh et al.   NUCLEIC ACIDS RESEARCH

Multimeric BLM is dissociated upon ATP hydrolysis and functions as monomers in resolving DNA structures

(2012) Ya-Nan Xu et al.   NUCLEIC ACIDS RESEARCH

Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains

(2012) Máté Gyimesi et al.   NUCLEIC ACIDS RESEARCH

The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures

(2012) Colleen Barefield et al.   NUCLEIC ACIDS RESEARCH

On the Interplay of Telomeres, Nevi and the Risk of Melanoma

(2012) Clara Bodelon et al.   PLoS One

RECQL4 in genomic instability and aging

(2012) Deborah L. Croteau et al.   TRENDS IN GENETICS

Exome Sequencing Identifies Rare Deleterious Mutations in DNA Repair Genes FANCC and BLM as Potential Breast Cancer Susceptibility Alleles

(2012) Ella R. Thompson et al.   PLoS Genetics

The N-terminal region of RECQL4 lacking the helicase domain is both essential and sufficient for the viability of vertebrate cells

(2011) Takuya Abe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Unique and important consequences of RECQ1 deficiency in mammalian cells

(2011) Sudha Sharma et al.   CELL CYCLE

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription

(2011) Patrick M. Grierson et al.   HUMAN MOLECULAR GENETICS

RECQL4, the Protein Mutated in Rothmund-Thomson Syndrome, Functions in Telomere Maintenance

(2011) Avik K. Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteome-wide Identification of WRN-Interacting Proteins in Untreated and Nuclease-Treated Samples

(2011) Sophie Lachapelle et al.   JOURNAL OF PROTEOME RESEARCH

The Set2-RPB1 Interaction Domain of Human RECQ5 Is Important for Transcription-Associated Genome Stability

(2011) M. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

(2011) Valerie Garcia et al.   NATURE

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

The involvement of human RECQL4 in DNA double-strand break repair

(2010) Dharmendra Kumar Singh et al.   AGING CELL

WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts

(2010) Alma Zecevic et al.   CELL CYCLE

Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding

(2010) Marie L. Rossi et al.   DNA REPAIR

ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

(2010) Francesca Ammazzalorso et al.   EMBO JOURNAL

WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations

(2010) Katrin Friedrich et al.   HUMAN GENETICS

Physical Interaction of RECQ5 Helicase with RAD51 Facilitates Its Anti-recombinase Activity

(2010) Sybille Schwendener et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA

(2010) Tina Thorslund et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CtIP promotes microhomology-mediated alternative end joining during class-switch recombination

(2010) Mieun Lee-Theilen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

(2010) Yu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rothmund-Thomson syndrome

(2010) Lidia Larizza et al.   Orphanet Journal of Rare Diseases

Structural Basis for DNA Strand Separation by the Unconventional Winged-Helix Domain of RecQ Helicase WRN

(2010) Ken Kitano et al.   STRUCTURE

Drosophila RecQ5 is required for efficient SSA repair and suppression of LOH in vivo

(2010) Yixu Chen et al.   Protein & Cell

A patient with Baller-Gerold syndrome and midline NK/T lymphoma

(2009) Marusa Debeljak et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication

(2009) Xiaohua Xu et al.   EMBO JOURNAL

Direct and indirect roles of RECQL4 in modulating base excision repair capacity

(2009) Shepherd H. Schurman et al.   HUMAN MOLECULAR GENETICS

Bloom Syndrome Helicase Stimulates RAD51 DNA Strand Exchange Activity through a Novel Mechanism

(2009) Dmitry V. Bugreev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bloom DNA Helicase Facilitates Homologous Recombination between Diverged Homologous Sequences

(2009) Koji Kikuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization

(2009) T. Dietschy et al.   JOURNAL OF CELL SCIENCE

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

(2009) Anyong Xie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential

(2009) Jay E. Johnson et al.   NUCLEIC ACIDS RESEARCH

MRE11 complex links RECQ5 helicase to sites of DNA damage

(2009) Lu Zheng et al.   NUCLEIC ACIDS RESEARCH

The Werner Syndrome Helicase/Exonuclease Processes Mobile D-Loops through Branch Migration and Degradation

(2009) Patricia L. Opresko et al.   PLoS One

Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

(2009) J.-S. Im et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eukaryotic DNA Ligases: Structural and Functional Insights

(2008) Tom Ellenberger et al.   Annual Review of Biochemistry

The zinc-binding motif of human RECQ5β suppresses the intrinsic strand-annealing activity of its DExH helicase domain and is essential for the helicase activity of the enzyme

(2008) Hua Ren et al.   BIOCHEMICAL JOURNAL

Werner Protein Cooperates with the XRCC4-DNA Ligase IV Complex in End-Processing†

(2008) Rika Kusumoto et al.   BIOCHEMISTRY

Intrinsic ssDNA Annealing Activity in the C-Terminal Region of WRN†

(2008) Meltem Muftuoglu et al.   BIOCHEMISTRY

Up-regulation of WRN and DNA ligase III  in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks

(2008) A. Sallmyr et al.   BLOOD

The mutation spectrum in RECQL4 diseases

(2008) H Annika Siitonen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

(2008) S. Gravel et al.   GENES & DEVELOPMENT

BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome

(2008) T. R. Singh et al.   GENES & DEVELOPMENT

RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability

(2008) D. Xu et al.   GENES & DEVELOPMENT

Sensitivity of RECQL4-deficient fibroblasts from Rothmund–Thomson syndrome patients to genotoxic agents

(2008) Weidong Jin et al.   HUMAN GENETICS

RecQ4 Facilitates UV Light-induced DNA Damage Repair through Interaction with Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A (XPA)

(2008) Wei Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE

Meningioma Associated With Werner Syndrome

(2008) Takao TSURUBUCHI et al.   NEUROLOGIA MEDICO-CHIRURGICA

Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

(2008) A. V. Nimonkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance

(2008) V BOHR   TRENDS IN BIOCHEMICAL SCIENCES

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics