CDK1 phosphorylates WRN at collapsed replication forks

The Werner syndrome protein: linking the replication checkpoint response to genome stability

(2016) Pietro Pichierri et al.   Aging-US

Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks

(2016) Rika Kusumoto-Matsuo et al.   Aging-US

Biochemical mechanism of DSB end resection and its regulation

(2015) James M. Daley et al.   DNA REPAIR

DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous Recombination

(2015) Petr Cejka   JOURNAL OF BIOLOGICAL CHEMISTRY

The N-terminus of RPA large subunit and its spatial position are important for the 5′->3′ resection of DNA double-strand breaks

(2015) Margaret Tammaro et al.   NUCLEIC ACIDS RESEARCH

DNA2 Cooperates with the WRN and BLM RecQ Helicases to Mediate Long-range DNA End Resection in Human Cells

(2014) Andreas Sturzenegger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress

(2014) Giorgia Basile et al.   NUCLEIC ACIDS RESEARCH

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

(2014) A. Mehta et al.   Cold Spring Harbor Perspectives in Biology

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

(2014) Nozomi Tomimatsu et al.   Nature Communications

Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway

(2013) M. Aggarwal et al.   CANCER RESEARCH

ATR phosphorylates SMARCAL1 to prevent replication fork collapse

(2013) F. B. Couch et al.   GENES & DEVELOPMENT

Regulation of the DNA Damage Response by Cyclin-Dependent Kinases

(2013) Camilla Trovesi et al.   JOURNAL OF MOLECULAR BIOLOGY

Repair of Double-Strand Breaks by End Joining

(2013) K. K. Chiruvella et al.   Cold Spring Harbor Perspectives in Biology

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

(2012) Nozomi Tomimatsu et al.   DNA REPAIR

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

Identification of Specific Inhibitors of Human RAD51 Recombinase Using High-Throughput Screening

(2011) Fei Huang et al.   ACS Chemical Biology

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes

(2011) B. S. Patro et al.   JOURNAL OF CELL SCIENCE

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

(2011) Xuefeng Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic analysis of Xenopus EXO1's function in 5'-strand resection at DNA double-strand breaks

(2011) S. Liao et al.   NUCLEIC ACIDS RESEARCH

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

(2010) Julia M. Sidorova et al.   CELL CYCLE

Roles of Werner syndrome protein in protection of genome integrity

(2010) Marie L. Rossi et al.   DNA REPAIR

ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

(2010) Francesca Ammazzalorso et al.   EMBO JOURNAL

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

(2010) Eun Yong Shim et al.   EMBO JOURNAL

Pathways of mammalian replication fork restart

(2010) Eva Petermann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

(2009) Pablo Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Roles of the Werner syndrome RecQ helicase in DNA replication

(2008) Julia M. Sidorova   DNA REPAIR

Comparison of nonhomologous end joining and homologous recombination in human cells

(2008) Z MAO et al.   DNA REPAIR

Werner syndrome helicase activity is essential in maintaining fragile site stability

(2008) Livia Maria Pirzio et al.   JOURNAL OF CELL BIOLOGY

A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

(2008) Aude Dupré et al.   Nature Chemical Biology

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE