RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription

RECQL5 : Another DNA helicase potentially involved in hereditary breast cancer susceptibility

(2019) Alejandra Tavera-Tapia et al.   HUMAN MUTATION

Replication Fork Activation Is Enabled by a Single-Stranded DNA Gate in CMG Helicase

(2019) Michael R. Wasserman et al.   CELL

RECQL5 plays an essential role in maintaining genome stability and viability of triple-negative breast cancer cells

(2019) Jin Peng et al.   Cancer Medicine

Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops

(2019) Nagaraja Chappidi et al.   MOLECULAR CELL

SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts

(2018) Min Li et al.   Nature Communications

Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress

(2018) Morgane Macheret et al.   NATURE

RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis

(2017) Stefano Di Marco et al.   MOLECULAR CELL

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5

(2017) Joseph A. Newman et al.   NUCLEIC ACIDS RESEARCH

RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells

(2016) Vaclav Urban et al.   JOURNAL OF CELL BIOLOGY

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

(2016) Rahul Bhowmick et al.   MOLECULAR CELL

Transcription–replication conflicts: how they occur and how they are resolved

(2016) Tatiana García-Muse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

Replication stress activates DNA repair synthesis in mitosis

(2015) Sheroy Minocherhomji et al.   NATURE

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability

(2015) Min Li et al.   Nature Communications

Human RecQ Helicases in DNA Repair, Recombination, and Replication

(2014) Deborah L. Croteau et al.   Annual Review of Biochemistry

RECQL5 Controls Transcript Elongation and Suppresses Genome Instability Associated with Transcription Stress

(2014) Marco Saponaro et al.   CELL

The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability

(2014) Stephan Hamperl et al.   DNA REPAIR

Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5

(2013) Susanne A Kassube et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcription-replication encounters, consequences and genomic instability

(2013) Anne Helmrich et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular recognition by the KIX domain and its role in gene regulation

(2013) J. K. Thakur et al.   NUCLEIC ACIDS RESEARCH

Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing

(2013) Shreya Paliwal et al.   NUCLEIC ACIDS RESEARCH

ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair

(2013) S. Mourgues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Variant of the Breast Cancer Type 2 Susceptibility Protein (BRC) Repeat Is Essential for the RECQL5 Helicase to Interact with RAD51 Recombinase for Genome Stabilization

(2012) M. Nurul Islam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homologous recombination and its regulation

(2012) L. Krejci et al.   NUCLEIC ACIDS RESEARCH

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

The Set2-RPB1 Interaction Domain of Human RECQ5 Is Important for Transcription-Associated Genome Stability

(2011) M. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

(2011) Anne Helmrich et al.   MOLECULAR CELL

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

The RecQ DNA Helicases in DNA Repair

(2010) Kara A. Bernstein et al.   Annual Review of Genetics

SF1 and SF2 helicases: family matters

(2010) Margaret E Fairman-Williams et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Physical Interaction of RECQ5 Helicase with RAD51 Facilitates Its Anti-recombinase Activity

(2010) Sybille Schwendener et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RecQL5 Promotes Genome Stabilization through Two Parallel Mechanisms--Interacting with RNA Polymerase II and Acting as a Helicase

(2010) M. N. Islam et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Structures of Crossover and Noncrossover Intermediates during Gap Repair in Yeast: Implications for Recombination

(2010) Katrina Mitchel et al.   MOLECULAR CELL

RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription

(2010) Radhakrishnan Kanagaraj et al.   NUCLEIC ACIDS RESEARCH

Direct Inhibition of RNA Polymerase II Transcription by RECQL5

(2009) Ozan Aygün et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MRE11 complex links RECQ5 helicase to sites of DNA damage

(2009) Lu Zheng et al.   NUCLEIC ACIDS RESEARCH

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

The zinc-binding motif of human RECQ5β suppresses the intrinsic strand-annealing activity of its DExH helicase domain and is essential for the helicase activity of the enzyme

(2008) Hua Ren et al.   BIOCHEMICAL JOURNAL

Association of human DNA helicase RecQ5β with RNA polymerase II and its possible role in transcription

(2008) Keiichi Izumikawa et al.   BIOCHEMICAL JOURNAL

A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin

(2008) O. Aygun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA