Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives
Authors
Keywords
-
Journal
Frontiers in Immunology
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-02-21
DOI
10.3389/fimmu.2021.611761
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Human α-synuclein overexpression in a mouse model of Parkinson’s disease leads to vascular pathology, blood brain barrier leakage and pericyte activation
- (2021) Osama Elabi et al. Scientific Reports
- The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State
- (2020) Matteo Runfola et al. Scientific Reports
- Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease
- (2020) Min Guo et al. BRAIN
- Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates
- (2020) Marie-Laure Arotcarena et al. BRAIN
- Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development
- (2020) Sebastian G. Utz et al. CELL
- The blood–brain barrier in health and disease: Important unanswered questions
- (2020) Caterina P. Profaci et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Defining molecular identity and fates of CNS-border associated macrophages after ischemic stroke in rodents and humans
- (2020) Wenson D. Rajan et al. NEUROBIOLOGY OF DISEASE
- Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease
- (2020) Wenjie Li et al. Experimental and Therapeutic Medicine
- Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
- (2020) Insup Choi et al. Nature Communications
- α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease
- (2020) Cecilia S. Lindestam Arlehamn et al. Nature Communications
- α-synuclein inclusions are abundant in non-neuronal cells in the anterior olfactory nucleus of the Parkinson’s disease olfactory bulb
- (2020) Taylor J. Stevenson et al. Scientific Reports
- Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson’s Disease
- (2020) Arianna Bellucci et al. Frontiers in Aging Neuroscience
- Extracellular clusterin limits the uptake of α‐synuclein fibrils by murine and human astrocytes
- (2020) Alice Filippini et al. GLIA
- The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson’s disease SNCA mutations
- (2020) Vivian Chen et al. HUMAN MOLECULAR GENETICS
- Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein
- (2020) Na Li et al. Journal of Neuroinflammation
- Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation
- (2020) Taiji Tsunemi et al. JOURNAL OF NEUROSCIENCE
- Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology
- (2019) Francesca Longhena et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cell Responses to Extracellular α-Synuclein
- (2019) Alexei A. Surguchev et al. MOLECULES
- Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein
- (2019) Wenyan Zou et al. Translational Neurodegeneration
- Plasma α -synuclein levels are increased in patients with obstructive sleep apnea syndrome
- (2019) Hao-Lun Sun et al. Annals of Clinical and Translational Neurology
- Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation
- (2019) Marta Joana Costa Jordão et al. SCIENCE
- Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- (2019) Valery L Feigin et al. LANCET NEUROLOGY
- α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease
- (2019) Zachary A. Sorrentino et al. ACTA NEUROPATHOLOGICA
- A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
- (2019) Hannah Van Hove et al. NATURE NEUROSCIENCE
- Monomeric α-synuclein induces blood–brain barrier dysfunction through activated brain pericytes releasing inflammatory mediators in vitro
- (2019) Shinya Dohgu et al. MICROVASCULAR RESEARCH
- Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders
- (2019) Allison J. Schaser et al. Scientific Reports
- Endothelial Targets in Stroke
- (2019) Anuska V. Andjelkovic et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities
- (2019) Parvez Alam et al. JOURNAL OF NEUROCHEMISTRY
- Brain perivascular macrophages: Recent advances and implications in health and diseases
- (2019) Tuo Yang et al. CNS Neuroscience & Therapeutics
- Alpha-Synuclein Preserves Mitochondrial Fusion and Function in Neuronal Cells
- (2019) Gaia Faustini et al. Oxidative Medicine and Cellular Longevity
- CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease
- (2019) Yuanyuan Li et al. Journal of Neuroinflammation
- Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury
- (2019) Hong Zeng et al. Journal of Neuroinflammation
- Dual microglia effects on blood brain barrier permeability induced by systemic inflammation
- (2019) Koichiro Haruwaka et al. Nature Communications
- Vessel-Associated Immune Cells in Cerebrovascular Diseases: From Perivascular Macrophages to Vessel-Associated Microglia
- (2019) Takashi Koizumi et al. Frontiers in Neuroscience
- Functional morphology of the blood–brain barrier in health and disease
- (2018) Stefan Liebner et al. ACTA NEUROPATHOLOGICA
- Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains
- (2018) Francesca Longhena et al. BRAIN PATHOLOGY
- High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease
- (2018) Dunja Mrdjen et al. IMMUNITY
- VEGF Signaling in Neurological Disorders
- (2018) Joon Shim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Microglial Phagocytosis and Its Regulation: A Therapeutic Target in Parkinson’s Disease?
- (2018) Elzbieta Janda et al. Frontiers in Molecular Neuroscience
- Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway
- (2018) Liyan Hou et al. Redox Biology
- Deep cervical lymph node ligation aggravates AD-like pathology of APP/PS1 mice
- (2018) Linmei Wang et al. BRAIN PATHOLOGY
- Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein
- (2018) Raquel Pinho et al. HUMAN MOLECULAR GENETICS
- Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease
- (2018) Sandro Da Mesquita et al. NATURE
- Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function
- (2018) Isabel Paiva et al. NEUROBIOLOGY OF DISEASE
- Microglia Response During Parkinson’s Disease: Alpha-Synuclein Intervention
- (2018) Sara A. Ferreira et al. Frontiers in Cellular Neuroscience
- CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage
- (2018) Jordi Pedragosa et al. Acta Neuropathologica Communications
- Enteric alpha-synuclein expression is increased in Crohn’s disease
- (2018) Alice Prigent et al. ACTA NEUROPATHOLOGICA
- The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing α-synuclein
- (2018) TaeHee Kim et al. Science Signaling
- Molecular characterization of perivascular drainage pathways in the murine brain
- (2017) Melanie-Jane Hannocks et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- The Threshold Theory for Parkinson's Disease
- (2017) Simone Engelender et al. TRENDS IN NEUROSCIENCES
- The End Is the Beginning: Parkinson’s Disease in the Light of Brain Imaging
- (2017) Arianna Bellucci et al. Frontiers in Aging Neuroscience
- The Synucleinopathies: Twenty Years On
- (2017) Michel Goedert et al. Journal of Parkinsons Disease
- The Contribution ofα-Synuclein Spreading to Parkinson’s Disease Synaptopathy
- (2017) Francesca Longhena et al. NEURAL PLASTICITY
- Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson’s Disease?
- (2017) Gaia Faustini et al. Genes
- The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer
- (2017) Jie Yin et al. Journal of Immunology Research
- Mitophagy in Parkinson’s Disease: Pathogenic and Therapeutic Implications
- (2017) Fei Gao et al. Frontiers in Neurology
- Curcumin affords neuroprotection and inhibits α-synuclein aggregation in lipopolysaccharide-induced Parkinson’s disease model
- (2017) Neha Sharma et al. INFLAMMOPHARMACOLOGY
- Parkinson disease
- (2017) Werner Poewe et al. Nature Reviews Disease Primers
- Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?
- (2017) Junichi Matsumoto et al. Acta Neuropathologica Communications
- α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson’s disease patients
- (2017) Birger Victor Dieriks et al. Scientific Reports
- Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke
- (2016) Melissa A. Lopes Pinheiro et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function
- (2016) Wei-Li Kuan et al. EXPERIMENTAL NEUROLOGY
- Macrophages Mediate the Repair of Brain Vascular Rupture through Direct Physical Adhesion and Mechanical Traction
- (2016) Chi Liu et al. IMMUNITY
- ɑ-Synuclein strains and the variable pathologies of synucleinopathies
- (2016) Wouter Peelaerts et al. JOURNAL OF NEUROCHEMISTRY
- Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration
- (2016) Hongwei Qin et al. JOURNAL OF NEUROSCIENCE
- Poststroke Induction of -Synuclein Mediates Ischemic Brain Damage
- (2016) T. Kim et al. JOURNAL OF NEUROSCIENCE
- Synaptic failure and α-synuclein
- (2016) Laura Calo et al. MOVEMENT DISORDERS
- Origin, fate and dynamics of macrophages at central nervous system interfaces
- (2016) Tobias Goldmann et al. NATURE IMMUNOLOGY
- Pericytes of the neurovascular unit: key functions and signaling pathways
- (2016) Melanie D Sweeney et al. NATURE NEUROSCIENCE
- Vascular endothelial growth factor: a neurovascular target in neurological diseases
- (2016) Christian Lange et al. Nature Reviews Neurology
- Extracellular vesicles round off communication in the nervous system
- (2016) Vivian Budnik et al. NATURE REVIEWS NEUROSCIENCE
- Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease
- (2016) Weiguo Peng et al. NEUROBIOLOGY OF DISEASE
- A comparative study of the amount of α-synuclein in ischemic stroke and Parkinson’s disease
- (2016) Hui-Qing Zhao et al. NEUROLOGICAL SCIENCES
- Review: Parkinson's disease: from synaptic loss to connectome dysfunction
- (2016) Arianna Bellucci et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Purinergic receptor P2RY12-dependent microglial closure of the injured blood–brain barrier
- (2016) Nanhong Lou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tissue-Resident CD169 + Macrophages Form a Crucial Front Line against Plasmodium Infection
- (2016) Pravesh Gupta et al. Cell Reports
- Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant
- (2016) Claire Hoenen et al. PLoS One
- Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies
- (2015) Anne Stuendl et al. BRAIN
- Post-translational modification of α-synuclein in Parkinson׳s disease
- (2015) Paul J. Barrett et al. BRAIN RESEARCH
- Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease
- (2015) Madison T Gray et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies
- (2015) Anna Villar-Piqué et al. JOURNAL OF NEUROCHEMISTRY
- Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson’s Disease via Protein Semisynthesis and Mutagenesis
- (2015) Ritwik Burai et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
- (2015) W. Peelaerts et al. NATURE
- α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation
- (2015) Shijun Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Parkinson's disease as a member of Prion-like disorders
- (2015) Maria Eugenia Herva et al. VIRUS RESEARCH
- The Blood–Brain Barrier
- (2015) Richard Daneman et al. Cold Spring Harbor Perspectives in Biology
- Novel subcellular localization for α-synuclein: possible functional consequences
- (2015) Cristina Guardia-Laguarta et al. Frontiers in Neuroanatomy
- String Vessel Formation is Increased in the Brain of Parkinson Disease
- (2015) Panzao Yang et al. Journal of Parkinsons Disease
- Mitochondrial Dysfunction andα-Synuclein Synaptic Pathology in Parkinson’s Disease: Who’s on First?
- (2015) Michela Zaltieri et al. Parkinsons Disease
- Alpha synuclein is transported into and out of the brain by the blood–brain barrier
- (2014) Yu-Ting Sui et al. PEPTIDES
- Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson’s disease with dementia and dementia with Lewy bodies compared to Alzheimer’s disease
- (2014) Oskar Hansson et al. Alzheimers Research & Therapy
- The Dynamic Structure of α-Synuclein Multimers
- (2013) Thomas Gurry et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD
- (2013) Chongwang Chang et al. NEUROSCIENCE LETTERS
- Large -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
- (2013) B.-K. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Factors regulating microglia activation
- (2013) Katrin Kierdorf et al. Frontiers in Cellular Neuroscience
- Endothelial Cell Heterogeneity
- (2013) W. C. Aird Cold Spring Harbor Perspectives in Medicine
- Vascular Degeneration in Parkinson's Disease
- (2012) Jian Guan et al. BRAIN PATHOLOGY
- From α-synuclein to synaptic dysfunctions: New insights into the pathophysiology of Parkinson's disease
- (2012) Arianna Bellucci et al. BRAIN RESEARCH
- Microglial Activation and Antioxidant Responses Induced by the Parkinson’s Disease Protein α-Synuclein
- (2012) Dawn Béraud et al. Journal of Neuroimmune Pharmacology
- Decreased reuptake of dopamine in the dorsal striatum in the absence of alpha-synuclein
- (2011) Heramb Chadchankar et al. BRAIN RESEARCH
- Evidence for angiogenesis in Parkinson’s disease, incidental Lewy body disease, and progressive supranuclear palsy
- (2011) Brinda Desai Bradaric et al. JOURNAL OF NEURAL TRANSMISSION
- Parenchymal accumulation of CD163+ macrophages/microglia in multiple sclerosis brains
- (2011) Zhiren Zhang et al. JOURNAL OF NEUROIMMUNOLOGY
- CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease
- (2011) Shi Zhang et al. Journal of Neuroinflammation
- Presence of Reactive Microglia and Neuroinflammatory Mediators in a Case of Frontotemporal Dementia with P301S Mutation
- (2011) Arianna Bellucci et al. Neurodegenerative Diseases
- The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding
- (2010) Tim Bartels et al. BIOPHYSICAL JOURNAL
- Role of GTPases in control of microvascular permeability
- (2010) V. Spindler et al. CARDIOVASCULAR RESEARCH
- Regulation of Weibel-Palade Body Exocytosis by α-Synuclein in Endothelial Cells
- (2010) Kwang Soo Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Absence of the αvβ3 Integrin Dictates the Time-Course of Angiogenesis in the Hypoxic Central Nervous System: Accelerated Endothelial Proliferation Correlates with Compensatory Increases in α5β1 Integrin Expression
- (2010) Longxuan Li et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Alpha-Synuclein Aggregation Induced by Brief Ischemia Negatively Impacts Neuronal Survival in vivo: A Study in [A30P]alpha-Synuclein Transgenic Mouse
- (2010) Isin Unal-Cevik et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- The role of alpha-synuclein in neurotransmission and synaptic plasticity
- (2010) Furong Cheng et al. JOURNAL OF CHEMICAL NEUROANATOMY
- Microglial activation state exerts a biphasic influence on brain endothelial cell proliferation by regulating the balance of TNF and TGF-β1
- (2010) Jennifer V Welser et al. Journal of Neuroinflammation
- α-Synuclein Delays Endoplasmic Reticulum (ER)-to-Golgi Transport in Mammalian Cells by Antagonizing ER/Golgi SNAREs
- (2010) Nandhakumar Thayanidhi et al. MOLECULAR BIOLOGY OF THE CELL
- Identification of the amino acid sequence motif of α-synuclein responsible for macrophage activation
- (2009) Saet-byul Lee et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Evidence That α-Synuclein Does Not Inhibit Phospholipase D†
- (2009) Irit Rappley et al. BIOCHEMISTRY
- The First N-terminal Amino Acids of α-Synuclein Are Essential for α-Helical Structure Formation In Vitro and Membrane Binding in Yeast
- (2009) Katherina Vamvaca et al. JOURNAL OF MOLECULAR BIOLOGY
- Distribution of the Immune Inhibitory Molecules CD200 and CD200R in the Normal Central Nervous System and Multiple Sclerosis Lesions Suggests Neuron-Glia and Glia-Glia Interactions
- (2009) Nathalie Koning et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Altered Regulation of CD200 Receptor in Monocyte-Derived Macrophages from Individuals with Parkinson’s Disease
- (2009) Xiao-Guang Luo et al. NEUROCHEMICAL RESEARCH
- [11C]-PK11195 PET: Quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?
- (2009) A.L. Bartels et al. PARKINSONISM & RELATED DISORDERS
- The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction
- (2009) Britta Engelhardt et al. Seminars in Immunopathology
- Driving Rho GTPase activity in endothelial cells regulates barrier integrity
- (2009) C. M. L. Beckers et al. THROMBOSIS AND HAEMOSTASIS
- Red Blood Cells Are the Major Source of Alpha-Synuclein in Blood
- (2008) Robin Barbour et al. Neurodegenerative Diseases
- Synuclein activates microglia in a model of Parkinson's disease
- (2007) Xiaomin Su et al. NEUROBIOLOGY OF AGING
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now