Balancing ER-Mitochondrial Ca2+ Fluxes in Health and Disease

BIRD-2, a BH4-domain-targeting peptide of Bcl-2, provokes Bax/Bak-independent cell death in B-cell cancers through mitochondrial Ca2+-dependent mPTP opening

(2021) Martijn Kerkhofs et al.   CELL CALCIUM

Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis

(2020) Rachel J. Perry et al.   NATURE

Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca 2+ ‐dependent death of cancer cells

(2020) Francesco Ciscato et al.   EMBO REPORTS

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

(2020) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease

(2020) Maria Calvo-Rodriguez et al.   Nature Communications

Nox4 regulates InsP 3 receptor‐dependent Ca 2+ release into mitochondria to promote cell survival

(2020) Matteo Beretta et al.   EMBO JOURNAL

Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome

(2020) Lien D. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca2+ transfer for survival

(2020) Cesar Cardenas et al.   Science Signaling

The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity

(2019) Patricia Gómez-Suaga et al.   Acta Neuropathologica Communications

How secret conversations inside cells are transforming biology

(2019) Elie Dolgin   NATURE

Familial Alzheimer’s disease-linked presenilin mutants and intracellular Ca2+ handling: A single-organelle, FRET-based analysis

(2019) Elisa Greotti et al.   CELL CALCIUM

Redox regulation of ER and mitochondrial Ca2+ signaling in cell survival and death

(2019) Suresh K. Joseph et al.   CELL CALCIUM

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

(2019) Amado Carreras-Sureda et al.   NATURE CELL BIOLOGY

Polycystin 2 regulates mitochondrial Ca2+ signaling, bioenergetics, and dynamics through mitofusin 2

(2019) Ivana Y. Kuo et al.   Science Signaling

Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective

(2019) Alessandro Rimessi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mutations in RHOT1 disrupt ER-mitochondria contact sites interfering with calcium homeostasis and mitochondrial dynamics in Parkinson’s disease

(2019) Dajana Grossmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential effect of glucose on ER-mitochondria Ca2+ exchange participates to insulin secretion and to glucotoxicity-mediated dysfunction of β cells.

(2019) Florian Dingreville et al.   DIABETES

Redox signals at the ER –mitochondria interface control melanoma progression

(2019) Xin Zhang et al.   EMBO JOURNAL

Characterization of NCS1–InsP3R1 interaction and its functional significance

(2019) Lien D. Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The functional universe of membrane contact sites

(2019) William A. Prinz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1

(2019) Yi Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer

(2019) Adam Bartok et al.   Nature Communications

NCS-1 is a regulator of calcium signaling in health and disease

(2018) Göran R. Boeckel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Breast Cancer Targeting through Inhibition of the Endoplasmic Reticulum-Based Apoptosis Regulator Nrh/BCL2L10

(2018) Adrien Nougarede et al.   CANCER RESEARCH

Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2

(2018) Mart Bittremieux et al.   CELL DEATH AND DIFFERENTIATION

Inositol Trisphosphate Receptor Type 3-mediated Enhancement of EGFR and MET Cotargeting Efficacy in Non–Small Cell Lung Cancer Detected by18F-fluorothymidine

(2018) Francesca Iommelli et al.   CLINICAL CANCER RESEARCH

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca 2+ Transfer

(2018) Riccardo Filadi et al.   CURRENT BIOLOGY

MCU Interacts with Miro1 to Modulate Mitochondrial Functions in Neurons

(2018) Robert F. Niescier et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions

(2018) György Csordás et al.   TRENDS IN CELL BIOLOGY

Wolfram syndrome: MAMs’ connection?

(2018) Benjamin Delprat et al.   Cell Death & Disease

The role of endoplasmic reticulum-mitochondria contact sites in the control of glucose homeostasis: an update

(2018) Jennifer Rieusset   Cell Death & Disease

STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca2+ fluxes and apoptotic responses

(2018) Lidia Avalle et al.   CELL DEATH AND DIFFERENTIATION

Mutation of hop-1 and pink-1 attenuates vulnerability of neurotoxicity in C. elegans: the role of mitochondria-associated membrane proteins in Parkinsonism

(2018) Siyu Wu et al.   EXPERIMENTAL NEUROLOGY

Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells

(2018) Suresh K. Joseph et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PDK4 Augments ER-Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity

(2018) Themis Thoudam et al.   DIABETES

Miro proteins prime mitochondria for Parkin translocation and mitophagy

(2018) Dzhamilja Safiulina et al.   EMBO JOURNAL

Aberrant IP3 receptor activities revealed by comprehensive analysis of pathological mutations causing spinocerebellar ataxia 29

(2018) Hideaki Ando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER-mitochondria cross-talk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome

(2018) Claire Angebault et al.   Science Signaling

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

A novel CISD2 mutation associated with a classical Wolfram syndrome phenotype alters Ca2+ homeostasis and ER-mitochondria interactions

(2017) Cécile Rouzier et al.   HUMAN MOLECULAR GENETICS

BOK displays cell death-independent tumor suppressor activity in non-small-cell lung carcinoma

(2017) Erika Moravcikova et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of Inositol 1, 4, 5-Trisphosphate Receptor Induce Breast Cancer Cell Death Through Deregulated Autophagy and Cellular Bioenergetics

(2017) Aru Singh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

(2017) Angela Bononi et al.   NATURE

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth

(2017) Shafi Kuchay et al.   NATURE

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

(2017) Fabao Liu et al.   NATURE CELL BIOLOGY

CISD2 Haploinsufficiency Disrupts Calcium Homeostasis, Causes Nonalcoholic Fatty Liver Disease, and Promotes Hepatocellular Carcinoma

(2017) Zhao-Qing Shen et al.   Cell Reports

Endoplasmic Reticulum–Mitochondrial Ca2+ Fluxes Underlying Cancer Cell Survival

(2017) Hristina Ivanova et al.   Frontiers in Oncology

Familial Alzheimer's Disease Mutations in Presenilins: Effects on Endoplasmic Reticulum Calcium Homeostasis and Correlation with Clinical Phenotypes

(2017) Omar Nelson et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduction of endoplasmic reticulum- mitochondria interactions in beta cells from patients with type 2 diabetes

(2017) Charles Thivolet et al.   PLoS One

Wolfram Syndrome: Diagnosis, Management, and Treatment

(2016) Fumihiko Urano   Current Diabetes Reports

FUNDC1 regulates mitochondrial dynamics at the ER–mitochondrial contact site under hypoxic conditions

(2016) Wenxian Wu et al.   EMBO JOURNAL

Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes

(2016) Dolores Del Prete et al.   JOURNAL OF ALZHEIMERS DISEASE

TMX1 determines cancer cell metabolism as a thiol-based modulator of ER–mitochondria Ca2+flux

(2016) Arun Raturi et al.   JOURNAL OF CELL BIOLOGY

Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production

(2016) Nuno Santos Leal et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Parkinson's disease

(2016) Michelle Grayson   NATURE

Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2

(2016) Riccardo Filadi et al.   Cell Reports

Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria

(2016) César Cárdenas et al.   Cell Reports

Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome

(2016) Michal Cagalinec et al.   PLOS BIOLOGY

IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact

(2016) Benjamin Bonneau et al.   eLife

Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

(2016) Weilin Zhang et al.   eLife

The SR/ER-mitochondria calcium crosstalk is regulated by GSK3β during reperfusion injury

(2015) L Gomez et al.   CELL DEATH AND DIFFERENTIATION

The BH4 Domain of Anti-apoptotic Bcl-XL, but Not That of the Related Bcl-2, Limits the Voltage-dependent Anion Channel 1 (VDAC1)-mediated Transfer of Pro-apoptotic Ca2+Signals to Mitochondria

(2015) Giovanni Monaco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death

(2015) Julien Prudent et al.   MOLECULAR CELL

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner

(2015) Carlotta Giorgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Ca2+ influx targets cardiolipin to disintegrate respiratory chain complex II for cell death induction

(2014) M-S Hwang et al.   CELL DEATH AND DIFFERENTIATION

Cisd2 modulates the differentiation and functioning of adipocytes by regulating intracellular Ca2+ homeostasis

(2014) Chih-Hao Wang et al.   HUMAN MOLECULAR GENETICS

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation

(2014) H Huang et al.   Cell Death & Disease

Non-apoptotic roles of Bcl-2 family: The calcium connection

(2013) Benjamin Bonneau et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner

(2013) A Bononi et al.   CELL DEATH AND DIFFERENTIATION

Molecular interaction and functional coupling between type 3 inositol 1,4,5-trisphosphate receptor and BKCa channel stimulate breast cancer cell proliferation

(2013) Abdallah Mound et al.   EUROPEAN JOURNAL OF CANCER

The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering

(2013) D. Ottolini et al.   HUMAN MOLECULAR GENETICS

The Bcl-2 Protein Family Member Bok Binds to the Coupling Domain of Inositol 1,4,5-Trisphosphate Receptors and Protects Them from Proteolytic Cleavage

(2013) Jacqualyn J. Schulman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Interaction between Bcl-xLand the Voltage-dependent Anion Channel (VDAC) Promotes Mitochondrial Ca2+Uptake

(2013) Huiya Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes

(2012) Yiguo Wang et al.   NATURE

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ero1α Regulates Ca2+ Fluxes at the Endoplasmic Reticulum–Mitochondria Interface (MAM)

(2011) Tiziana Anelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caffeine-Mediated Inhibition of Calcium Release Channel Inositol 1,4,5-Trisphosphate Receptor Subtype 3 Blocks Glioblastoma Invasion and Extends Survival

(2010) S. S. Kang et al.   CANCER RESEARCH

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

The type III inositol 1,4,5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma

(2010) Kazunori Shibao et al.   CELL CALCIUM

Ca2+ Hot Spots on the Mitochondrial Surface Are Generated by Ca2+ Mobilization from Stores, but Not by Activation of Store-Operated Ca2+ Channels

(2010) Marta Giacomello et al.   MOLECULAR CELL

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

(2010) György Csordás et al.   MOLECULAR CELL

PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release

(2010) C. Giorgi et al.   SCIENCE

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

(2009) Estela Area-Gomez et al.   AMERICAN JOURNAL OF PATHOLOGY

Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1

(2009) Natasha C Chang et al.   EMBO JOURNAL

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Altered Ca2+ homeostasis in the skeletal muscle of DJ−1 null mice

(2009) Alexander Shtifman et al.   NEUROBIOLOGY OF AGING

Polycystic Kidney Disease

(2008) Peter C. Harris et al.   Annual Review of Medicine

Bcl-B Expression in Human Epithelial and Nonepithelial Malignancies

(2008) M. Krajewska et al.   CLINICAL CANCER RESEARCH

Targeting Bcl-2-IP3 Receptor Interaction to Reverse Bcl-2's Inhibition of Apoptotic Calcium Signals

(2008) Yi-Ping Rong et al.   MOLECULAR CELL

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis

(2008) T. Szado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

(2008) M. Saotome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA