A novel CISD2 mutation associated with a classical Wolfram syndrome phenotype alters Ca2+ homeostasis and ER-mitochondria interactions

Unilateral renal cystic disease in the left kidney

(2016) Tae Ryom Oh et al.   Clinical and Experimental Nephrology

Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome

(2016) Michal Cagalinec et al.   PLOS BIOLOGY

Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in insulin insensitivity of mammalian cells

(2015) Chih-Hao Wang et al.   Annals of the New York Academy of Sciences

Calcium signaling as a mediator of cell energy demand and a trigger to cell death

(2015) Gauri Bhosale et al.   Annals of the New York Academy of Sciences

Wolfram syndrome 2: a novel CISD2 mutation identified in Italian siblings

(2014) Maurizio Rondinelli et al.   ACTA DIABETOLOGICA

New functions of mitochondria associated membranes in cellular signaling

(2014) Alexander R. van Vliet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A novel CISD2 intragenic deletion, optic neuropathy and platelet aggregation defect in Wolfram syndrome type 2

(2014) Enza Mozzillo et al.   BMC Medical Genetics

Cisd2 mediates lifespan: is there an interconnection among Ca2+homeostasis, autophagy, and lifespan?

(2014) C.-H. Wang et al.   FREE RADICAL RESEARCH

Cisd2 modulates the differentiation and functioning of adipocytes by regulating intracellular Ca2+ homeostasis

(2014) Chih-Hao Wang et al.   HUMAN MOLECULAR GENETICS

Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+homeostasis

(2013) Sandra E. Wiley et al.   EMBO Molecular Medicine

Free Fatty Acid Induces Endoplasmic Reticulum Stress and Apoptosis of β-cells by Ca2+/Calpain-2 Pathways

(2013) Wei Cui et al.   PLoS One

BCL2-CISD2

(2012) Natasha C. Chang et al.   Autophagy

A persistent level of Cisd2 extends healthy lifespan and delays aging in mice

(2012) Chia-Yu Wu et al.   HUMAN MOLECULAR GENETICS

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

(2011) R. Bravo et al.   JOURNAL OF CELL SCIENCE

Neurologic features and genotype-phenotype correlation in Wolfram syndrome

(2010) Annabelle Chaussenot et al.   ANNALS OF NEUROLOGY

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

(2010) Sonya G. Fonseca et al.   JOURNAL OF CLINICAL INVESTIGATION

SLP-2 is required for stress-induced mitochondrial hyperfusion

(2009) Daniel Tondera et al.   EMBO JOURNAL

Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1

(2009) Natasha C Chang et al.   EMBO JOURNAL

Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice

(2009) Y.-F. Chen et al.   GENES & DEVELOPMENT

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response

(2009) Sebastian Schuck et al.   JOURNAL OF CELL BIOLOGY

Crystal Structure of Miner1: The Redox-active 2Fe-2S Protein Causative in Wolfram Syndrome 2

(2009) Andrea R. Conlan et al.   JOURNAL OF MOLECULAR BIOLOGY

Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content

(2008) C. Jane Hanson et al.   CELL CALCIUM

Role of SERCA1 Truncated Isoform in the Proapoptotic Calcium Transfer from ER to Mitochondria during ER Stress

(2008) Mounia Chami et al.   MOLECULAR CELL