Redox signals at the ER –mitochondria interface control melanoma progression

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

(2018) William C. Stafford et al.   Science Translational Medicine

Characterization of Naïve and Vitamin C-Treated Mouse Schwann Cell Line MSC80: Induction of the Antioxidative Thioredoxin Related Transmembrane Protein 1

(2018) Vietxuan Phan et al.   JOURNAL OF PROTEOME RESEARCH

Mitochondrial Ca 2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity

(2017) Zhiwei Dong et al.   MOLECULAR CELL

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

A pathology atlas of the human cancer transcriptome

(2017) Mathias Uhlen et al.   SCIENCE

Mitochondrial ROS control of cancer

(2017) María del Pilar Sosa Idelchik et al.   SEMINARS IN CANCER BIOLOGY

ROS in Cancer: The Burning Question

(2017) Iok In Christine Chio et al.   TRENDS IN MOLECULAR MEDICINE

Decoding NADPH oxidase 4 expression in human tumors

(2017) Jennifer L. Meitzler et al.   Redox Biology

Regulation of Endoplasmic Reticulum–Mitochondria Ca2+ Transfer and Its Importance for Anti-Cancer Therapies

(2017) Gaia Pedriali et al.   Frontiers in Oncology

CRAC channels, calcium, and cancer in light of the driver and passenger concept

(2016) Markus Hoth   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

NFAT1 Directly Regulates IL8 and MMP3 to Promote Melanoma Tumor Growth and Metastasis

(2016) E. Shoshan et al.   CANCER RESEARCH

Imaging calcium and redox signals using genetically encoded fluorescent indicators

(2016) Christine S. Gibhardt et al.   CELL CALCIUM

Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2 -mediated stress signaling

(2016) C. X. Santos et al.   EMBO JOURNAL

Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish

(2016) Christian Appenzeller-Herzog et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein

(2016) Kim-Kristin Prior et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMX1 determines cancer cell metabolism as a thiol-based modulator of ER–mitochondria Ca2+flux

(2016) Arun Raturi et al.   JOURNAL OF CELL BIOLOGY

The role of Orai-STIM calcium channels in melanocytes and melanoma

(2016) Hedwig Stanisz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface

(2016) David M. Booth et al.   MOLECULAR CELL

Mitofusins, from Mitochondria to Metabolism

(2016) Emilie Schrepfer et al.   MOLECULAR CELL

A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+channels

(2016) Stephanie Saul et al.   Science Signaling

Imaging mitochondrial dynamics in human skin reveals depth-dependent hypoxia and malignant potential for diagnosis

(2016) D. Pouli et al.   Science Translational Medicine

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria

(2016) César Cárdenas et al.   Cell Reports

A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+channels

(2016) Stephanie Saul et al.   Science Signaling

PPIXpress: construction of condition-specific protein interaction networks based on transcript expression

(2015) Thorsten Will et al.   BIOINFORMATICS

The Ca2+-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca2+ Uptake

(2015) Carmelina Petrungaro et al.   Cell Metabolism

Redox Homeostasis and Mitochondrial Dynamics

(2015) Peter H.G.M. Willems et al.   Cell Metabolism

Novel Protein Kinase C-Mediated Control of Orai1 Function in Invasive Melanoma

(2015) Robert Hooper et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct Spatial Ca2+ Signatures Selectively Activate Different NFAT Transcription Factor Isoforms

(2015) Pulak Kar et al.   MOLECULAR CELL

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

AKT1 Activation Promotes Development of Melanoma Metastases

(2015) Joseph H. Cho et al.   Cell Reports

Melanoma

(2015) Dirk Schadendorf et al.   Nature Reviews Disease Primers

Mitochondrial function in melanoma

(2014) Nicholas Theodosakis et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Endoplasmic Reticulum Stress in Malignancy

(2014) Hanna J. Clarke et al.   CANCER CELL

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The GOA database: Gene Ontology annotation updates for 2015

(2014) Rachael P. Huntley et al.   NUCLEIC ACIDS RESEARCH

Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry

(2014) Hedwig Stanisz et al.   Pigment Cell & Melanoma Research

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin

(2014) Sohum Mehta et al.   eLife

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

(2013) Alexander Roesch et al.   CANCER CELL

NFAT Gene Family in Inflammation and Cancer

(2013) M.-G. Pan et al.   CURRENT MOLECULAR MEDICINE

An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry

(2013) Sonia Sharma et al.   NATURE

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Concurrent MEK2 Mutation and BRAF Amplification Confer Resistance to BRAF and MEK Inhibitors in Melanoma

(2013) Jessie Villanueva et al.   Cell Reports

HyPer-3: A Genetically Encoded H2O2 Probe with Improved Performance for Ratiometric and Fluorescence Lifetime Imaging

(2012) Dmitry S. Bilan et al.   ACS Chemical Biology

NFATc2 Is a Potential Therapeutic Target in Human Melanoma

(2012) Valentina Perotti et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endoplasmic reticulum–mitochondria coupling: local Ca2+ signalling with functional consequences

(2012) Daniel Bakowski et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Redox regulation of calcium ion channels: Chemical and physiological aspects

(2011) Ivan Bogeski et al.   CELL CALCIUM

Palmitoylated TMX and calnexin target to the mitochondria-associated membrane

(2011) Emily M Lynes et al.   EMBO JOURNAL

Dynamic Regulation of the Mitochondrial Proton Gradient during Cytosolic Calcium Elevations

(2011) Damon Poburko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Real-time monitoring of redox changes in the mammalian endoplasmic reticulum

(2011) M. van Lith et al.   JOURNAL OF CELL SCIENCE

Staying in touch: the molecular era of organelle contact sites

(2011) Yael Elbaz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

(2010) Jessie Villanueva et al.   CANCER CELL

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

(2010) György Csordás et al.   MOLECULAR CELL

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma

(2009) R J Flockhart et al.   BRITISH JOURNAL OF CANCER

NADPH Oxidase 4 Contributes to Transformation Phenotype of Melanoma Cells by Regulating G2-M Cell Cycle Progression

(2009) M. Yamaura et al.   CANCER RESEARCH

Reactive oxygen species-dependent signaling regulates cancer

(2009) Frank Weinberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis

(2008) R. Brooks Robey et al.   SEMINARS IN CANCER BIOLOGY