NETosis as a Pathogenic Factor for Heart Failure

Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis Following Myocardial Infarction

(2020) Gopalkrishna Sreejit et al.   CIRCULATION

Serum Albumin Is a Marker of Myocardial Fibrosis, Adverse Pulsatile Aortic Hemodynamics, and Prognosis in Heart Failure With Preserved Ejection Fraction

(2020) Stuart B. Prenner et al.   Journal of the American Heart Association

Distinct Pathological Pathways in Patients With Heart Failure and Diabetes

(2020) Jasper Tromp et al.   JACC-Heart Failure

Mitochondrial permeability transition pore is involved in oxidative burst and NETosis of human neutrophils

(2020) Nina Vorobjeva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mechanisms of Chronotropic Incompetence in Heart Failure With Preserved Ejection Fraction

(2020) Satyam Sarma et al.   Circulation-Heart Failure

COVID-19-related myocarditis in a 21-year-old female patient

(2020) In-Cheol Kim et al.   EUROPEAN HEART JOURNAL

Metformin and heart failure–related outcomes in patients with or without diabetes: a systematic review of randomized controlled trials

(2020) Phiwayinkosi V. Dludla et al.   HEART FAILURE REVIEWS

CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

(2020) Álvaro Teijeira et al.   IMMUNITY

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Covid-19 “Fulminant Myocarditis” Successfully Treated With Temporary Mechanical Circulatory Support

(2020) Jorge Salamanca et al.   JACC-Cardiovascular Imaging

Endothelial Sirtuin 3 Dictates Glucose Transport to Cardiomyocyte and Sensitizes Pressure Overload‐Induced Heart Failure

(2020) Heng Zeng et al.   Journal of the American Heart Association

Myeloperoxidase and related biomarkers are suggestive footprints of endothelial microvascular inflammation in HFpEF patients

(2020) Camilla Hage et al.   ESC Heart Failure

Serum alarmin S100A8/S100A9 levels and its potential role as biomarker in myocarditis

(2020) Irene Müller et al.   ESC Heart Failure

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

Metabolic Inflammation in Heart Failure with Preserved Ejection Fraction

(2020) Gabriele G Schiattarella et al.   CARDIOVASCULAR RESEARCH

COP9 Signalosome Suppresses RIPK1-RIPK3–Mediated Cardiomyocyte Necroptosis in Mice

(2020) Peng Xiao et al.   Circulation-Heart Failure

Heart failure development in obesity: mechanistic pathways

(2020) Kristjan Karason et al.   EUROPEAN HEART JOURNAL

Epidemiology of heart failure

(2020) Amy Groenewegen et al.   EUROPEAN JOURNAL OF HEART FAILURE

miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis

(2020) Ana B. Arroyo et al.   HAEMATOLOGICA

Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis

(2020) Carmelo Carmona-Rivera et al.   JCI Insight

IL-33-induced neutrophil extracellular traps degrade fibronectin in a murine model of bronchopulmonary dysplasia

(2020) Rui Jin et al.   Cell Death Discovery

Anti-modified citrullinated vimentin antibody: a novel biomarker associated with cardiac systolic dysfunction in patients with rheumatoid arthritis

(2020) Somayye Norouzi et al.   BMC Cardiovascular Disorders

Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

(2020) Panagiotis Skendros et al.   JOURNAL OF CLINICAL INVESTIGATION

Heart Failure in Type 2 Diabetes Mellitus

(2019) Helena C. Kenny et al.   CIRCULATION RESEARCH

Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records

(2019) Alicia Uijl et al.   EUROPEAN JOURNAL OF HEART FAILURE

Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis

(2019) Ludwig T. Weckbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition

(2019) Rachel J. Roth Flach et al.   PLoS One

Induction of neutrophil extracellular traps during tissue injury: Involvement of STING and Toll-like receptor 9 pathways

(2019) Li Liu et al.   CELL PROLIFERATION

Novel findings in neutrophil biology and their impact on cardiovascular disease

(2019) Aldo Bonaventura et al.   CARDIOVASCULAR RESEARCH

Predictors of neutrophil extracellular traps markers in type 2 diabetes mellitus: associations with a prothrombotic state and hypofibrinolysis

(2019) Agata H. Bryk et al.   Cardiovascular Diabetology

Excessive Neutrophil Extracellular Trap Formation Aggravates Acute Myocardial Infarction Injury in Apolipoprotein E Deficiency Mice via the ROS-Dependent Pathway

(2019) Zheliang Zhou et al.   Oxidative Medicine and Cellular Longevity

A Novel Assay for Neutrophil Extracellular Traps (NETs) Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients

(2019) Simon T Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction

(2019) Thomas M. Hofbauer et al.   BASIC RESEARCH IN CARDIOLOGY

High sensitivity C-Reactive Protein in Chronic Heart Failure: Patient Characteristics, Phenotypes and Mode of Death

(2019) Pierpaolo Pellicori et al.   CARDIOVASCULAR RESEARCH

S100a8/a9 Signaling Causes Mitochondrial Dysfunction and Cardiomyocytes Death in Response Ischemic/Reperfusion Injury

(2019) Yulin Li et al.   CIRCULATION

Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis after Vessel Injury

(2019) Nicoletta Sorvillo et al.   CIRCULATION RESEARCH

Statins in the Prevention and Treatment of Heart Failure: a Review of the Evidence

(2019) Matthew M. Y. Lee et al.   Current Atherosclerosis Reports

Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain

(2019) Seung-Woo Kim et al.   Acta Neuropathologica Communications

Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer

(2019) Ariela Benigni et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibiting nucleolin reduce inflammation induced by mitochondrial DNA in cardiomyocytes exposed to hypoxia and reoxygenation

(2019) Lars Henrik Mariero et al.   BRITISH JOURNAL OF PHARMACOLOGY

Wnt5a-Mediated Neutrophil Recruitment Has an Obligatory Role in Pressure Overload–Induced Cardiac Dysfunction

(2019) Ying Wang et al.   CIRCULATION

Extracellular DNA NET-Works With Dire Consequences for Health

(2019) Nicoletta Sorvillo et al.   CIRCULATION RESEARCH

Effect of Serum Albumin Levels in Patients With Heart Failure With Preserved Ejection Fraction (from the TOPCAT Trial)

(2019) Stuart B. Prenner et al.   AMERICAN JOURNAL OF CARDIOLOGY

Mitochondrial DNA Stimulates TLR9-Dependent NET Formation in Primary Graft Dysfunction

(2019) Beñat Mallavia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Prevalence of heart failure and left ventricular dysfunction in China: the China Hypertension Survey, 2012–2015

(2019) Guang Hao et al.   EUROPEAN JOURNAL OF HEART FAILURE

miR-129-5p improves cardiac function in rats with chronic heart failure through targeting HMGB1

(2019) Na Xiao et al.   MAMMALIAN GENOME

Neutrophil Extracellular Trap Components Associate with Infarct Size, Ventricular Function, and Clinical Outcome in STEMI

(2019) Ragnhild Helseth et al.   MEDIATORS OF INFLAMMATION

Neutrophil Elastase Inhibition Ameliorates Endotoxin-Induced Myocardial Injury Accompanying Degradation of Cardiac Capillary Glycocalyx

(2019) Tetsuya Fukuta et al.   SHOCK

Increased plasmatic NETs by-products in patients in severe obesity

(2019) Marco D’Abbondanza et al.   Scientific Reports

Diagnostic and Therapeutic Gaps in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease

(2019) Marco Canepa et al.   JACC-Heart Failure

Interleukin-1β Mediates Arterial Thrombus Formation via NET-Associated Tissue Factor

(2019) Luca Liberale et al.   Journal of Clinical Medicine

Value of Neutrophil to Lymphocyte Ratio and Its Trajectory in Patients Hospitalized With Acute Heart Failure and Preserved Ejection Fraction

(2019) Kalyani Anil Boralkar et al.   AMERICAN JOURNAL OF CARDIOLOGY

Interdependence of Atrial Fibrillation and Heart Failure With a Preserved Ejection Fraction Reflects a Common Underlying Atrial and Ventricular Myopathy

(2019) Milton Packer et al.   CIRCULATION

Predominant Involvement of the Aortic Root in a Patient with Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis: Congestive Heart Failure due to Subacute Severe Aortic Regurgitation and Reversible Conduction Disturbance

(2019) Atsusuke Yatomi et al.   INTERNAL MEDICINE

Inhibition of peptidyl arginine deiminase-4 protects against myocardial infarction induced cardiac dysfunction

(2019) Mingjun Du et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Activation leads to a significant shift in the intracellular redox homeostasis of neutrophil-like cells

(2019) Kaibo Xie et al.   Redox Biology

The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo

(2018) Lisa Menegazzo et al.   ACTA DIABETOLOGICA

The chlorinated lipidome originating from myeloperoxidase-derived HOCl targeting plasmalogens: Metabolism, clearance, and biological properties

(2018) Elisa N.D. Palladino et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

MiR-146a Regulates Neutrophil Extracellular Trap Formation That Predicts Adverse Cardiovascular Events in Patients With Atrial FibrillationHighlights

(2018) Ana B. Arroyo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Novel Role of IL (Interleukin)-1β in Neutrophil Extracellular Trap Formation and Abdominal Aortic AneurysmsHighlights

(2018) Akshaya K. Meher et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Analyzing gene expression profiles with preliminary validations in cardiac hypertrophy induced by pressure overload

(2018) Jing Gao et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Thromboembolic findings in patients with heart failure at autopsy

(2018) Isabella Sales de Macedo et al.   CARDIOVASCULAR PATHOLOGY

Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity

(2018) Daniel S Gaul et al.   CARDIOVASCULAR RESEARCH

Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure

(2018) Iñigo Valiente-Alandi et al.   CIRCULATION

MicroRNA-195 Regulates Metabolism in Failing Myocardium Via Alterations in Sirtuin 3 Expression and Mitochondrial Protein Acetylation

(2018) Xiaokan Zhang et al.   CIRCULATION

CXCL1–CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration

(2018) Lei Wang et al.   EUROPEAN HEART JOURNAL

Peptidylarginine deiminase 4: a nuclear button triggering neutrophil extracellular traps in inflammatory diseases and aging

(2018) Siu Ling Wong et al.   FASEB JOURNAL

Targeting HMGB1 ameliorates cardiac fibrosis through restoring TLR2-mediated autophagy suppression in myocardial fibroblasts

(2018) Ri-Na Wu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

2-Chlorofatty acids: Lipid mediators of neutrophil extracellular trap formation

(2018) Elisa N.D. Palladino et al.   JOURNAL OF LIPID RESEARCH

Risk of Cardiovascular Disease and Venous Thromboembolism Among Patients With Incident ANCA-Associated Vasculitis: A 20-Year Population-Based Cohort Study

(2018) Alvise Berti et al.   MAYO CLINIC PROCEEDINGS

Histological comparison of arterial thrombi in mice and men and the influence of Cl-amidine on thrombus formation

(2018) Julia Novotny et al.   PLoS One

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

(2018) Ofir Wolach et al.   Science Translational Medicine

Deletion of Extra Domain A of Fibronectin Reduces Acute Myocardial Ischaemia/Reperfusion Injury in Hyperlipidaemic Mice by Limiting Thrombo-Inflammation

(2018) Mehul Chorawala et al.   THROMBOSIS AND HAEMOSTASIS

Neutrophil Extracellular Traps Participate in All Different Types of Thrombotic and Haemorrhagic Complications of Coronary Atherosclerosis

(2018) Kartika Pertiwi et al.   THROMBOSIS AND HAEMOSTASIS

Heart failure in systemic lupus erythematosus

(2018) Bishnu P. Dhakal et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Prosarcopenic Effects of Statins May Limit Their Effectiveness in Patients with Heart Failure

(2018) Agata Bielecka-Dabrowa et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive—A New Preclinical Model

(2018) Claire L. Curl et al.   Journal of the American Heart Association

Secretion of the Phosphorylated Form of S100A9 from Neutrophils Is Essential for the Proinflammatory Functions of Extracellular S100A8/A9

(2018) Véronique Schenten et al.   Frontiers in Immunology

Post-Myocardial Infarction Heart Failure

(2018) M. Cecilia Bahit et al.   JACC-Heart Failure

Clinical Spectrum and Management of Heart Failure in Hypertrophic Cardiomyopathy

(2018) Barry J. Maron et al.   JACC-Heart Failure

Stimulus-dependent chromatin dynamics, citrullination, calcium signalling and ROS production during NET formation

(2018) Cynthia M. de Bont et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cooperative PSGL-1 and CXCR2 signaling in neutrophils promotes deep vein thrombosis in mice

(2018) Tadayuki Yago et al.   BLOOD

Neutrophils contribute to vasculitis by increased release of neutrophil extracellular traps in BEHÇET’S disease

(2018) Rémi Safi et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Obesity-induced Endothelial Dysfunction is Prevented by Neutrophil Extracellular Trap Inhibition

(2018) Hui Wang et al.   Scientific Reports

Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils

(2018) Yebin Zhou et al.   Scientific Reports

Treating oxidative stress in heart failure: past, present and future

(2018) Atze van der Pol et al.   EUROPEAN JOURNAL OF HEART FAILURE

Role of neutrophils in CVB3 infection and viral myocarditis

(2018) Leonardo Rivadeneyra et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Peptidyl arginine deiminase inhibition suppresses arthritis via decreased protein citrullination in joints and serum with the downregulation of interleukin-6

(2018) Hoshimi Kawaguchi et al.   Modern Rheumatology

Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis

(2018) Minoru Inoue et al.   Nature Communications

Indoxyl Sulfate Promotes Arterial Thrombosis in Rat Model via Increased Levels of Complex TF/VII, PAI-1, Platelet Activation as Well as Decreased Contents of SIRT1 and SIRT3

(2018) Malgorzata Karbowska et al.   Frontiers in Physiology

Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis

(2018) Weiqian Chen et al.   Journal of Immunology Research

Relation of Neutrophil to Lymphocyte Ratio to Risk of Incident Atrial Fibrillation

(2018) Anat Berkovitch et al.   AMERICAN JOURNAL OF CARDIOLOGY

Redox regulation of cardiovascular inflammation – Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species

(2017) Philip Wenzel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Correlation Between Mitochondrial DNA Content Measured in Myocardium and Peripheral Blood of Patients with Non-Ischemic Heart Failure

(2017) Judita Knez et al.   Genetic Testing and Molecular Biomarkers

Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK

(2017) Gang Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Myeloid-related protein-8/14 in acute coronary syndrome

(2017) Masashi Sakuma et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Increased levels of neutrophil extracellular trap remnants in the serum of patients with rheumatoid arthritis

(2017) Wei Wang et al.   International Journal of Rheumatic Diseases

Bacterial Siderophores Hijack Neutrophil Functions

(2017) Piu Saha et al.   JOURNAL OF IMMUNOLOGY

Plasma-derived exosomes contribute to inflammation via the TLR9-NF-κB pathway in chronic heart failure patients

(2017) Wei Ye et al.   MOLECULAR IMMUNOLOGY

An emerging role for neutrophil extracellular traps in noninfectious disease

(2017) Selina K Jorch et al.   NATURE MEDICINE

Elevated calprotectin in patients with atrial fibrillation with and without heart failure

(2017) Lærke V. Bruhn et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Experimental and Human Evidence for Lipocalin‐2 (Neutrophil Gelatinase‐Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure

(2017) Francine Z. Marques et al.   Journal of the American Heart Association

NETosis before and after Hyperglycemic Control in Type 2 Diabetes Mellitus Patients

(2017) Agostina Carestia et al.   PLoS One

Detection of Soluble ED-A+Fibronectin and Evaluation as Novel Serum Biomarker for Cardiac Tissue Remodeling

(2016) Barbara Ziffels et al.   DISEASE MARKERS

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2016) Piotr Ponikowski et al.   EUROPEAN HEART JOURNAL

Mitochondrial involvement in myocyte death and heart failure

(2016) Michael J. Goldenthal   HEART FAILURE REVIEWS

Midkine Deteriorates Cardiac Remodeling via Epidermal Growth Factor Receptor Signaling in Chronic Kidney DiseaseNovelty and Significance

(2016) Yuki Honda et al.   HYPERTENSION

Peptidylarginine deiminase 4 promotes age-related organ fibrosis

(2016) Kimberly Martinod et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory and fibrotic responses of cardiac fibroblasts to myocardial damage associated molecular patterns (DAMPs)

(2016) Neil A. Turner   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Superoxide Induces Neutrophil Extracellular Trap Formation in a TLR-4 and NOX-Dependent Mechanism

(2016) Ahmed B Al-Khafaji et al.   MOLECULAR MEDICINE

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Circulating Neutrophil Extracellular Trap Levels in Well-Controlled Type 2 Diabetes and Pathway Involved in Their Formation Induced by High-Dose Glucose

(2016) Arina Miyoshi et al.   PATHOBIOLOGY

Serum free thiols in chronic heart failure

(2016) Anne M. Koning et al.   PHARMACOLOGICAL RESEARCH

Association of anti-citrullinated protein or peptide antibodies with left ventricular structure and function in rheumatoid arthritis

(2016) Laura Geraldino-Pardilla et al.   RHEUMATOLOGY

Phosphotidylserine exposure and neutrophil extracellular traps enhance procoagulant activity in patients with inflammatory bowel disease

(2016) Ruishuang Ma et al.   THROMBOSIS AND HAEMOSTASIS

Peptidylarginine Deiminase Inhibitor Suppresses Neutrophil Extracellular Trap Formation and MPO-ANCA Production

(2016) Yoshihiro Kusunoki et al.   Frontiers in Immunology

Oxidative Burst-Dependent NETosis Is Implicated in the Resolution of Necrosis-Associated Sterile Inflammation

(2016) Mona H. C. Biermann et al.   Frontiers in Immunology

Inflammation in Heart Failure With Preserved Ejection Fraction

(2016) Mardi Gomberg-Maitland et al.   JACC-Heart Failure

Circulating Level of Neutrophil Extracellular Traps Is Not a Useful Biomarker for Assessing Disease Activity in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

(2016) Huan Wang et al.   PLoS One

Usefulness of Neutrophil-to-Lymphocyte Ratio in Risk Stratification of Patients With Advanced Heart Failure

(2015) Vicente A. Benites-Zapata et al.   AMERICAN JOURNAL OF CARDIOLOGY

Neutrophil extracellular traps in ischemia-reperfusion injury-induced myocardial no-reflow: therapeutic potential of DNase-based reperfusion strategy

(2015) Lan Ge et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Citrullination and autoimmunity

(2015) Guido Valesini et al.   AUTOIMMUNITY REVIEWS

Cellular fibronectin containing extra domain A promotes arterial thrombosis in mice through platelet Toll-like receptor 4

(2015) P. Prakash et al.   BLOOD

Citrullination of myofilament proteins in heart failure

(2015) Justyna Fert-Bober et al.   CARDIOVASCULAR RESEARCH

PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling

(2015) Jyaysi Desai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neutrophil NET formation is regulated from the inside by myeloperoxidase-processed reactive oxygen species

(2015) Halla Björnsdottir et al.   FREE RADICAL BIOLOGY AND MEDICINE

Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

(2015) Hai Huang et al.   HEPATOLOGY

Increased serum HMGB1 level may predict the fatal outcomes in patients with chronic heart failure

(2015) Tao Liu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Extracellular high-mobility group box 1 mediates pressure overload-induced cardiac hypertrophy and heart failure

(2015) Lei Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Platelet-derived HMGB1 is a critical mediator of thrombosis

(2015) Sebastian Vogel et al.   JOURNAL OF CLINICAL INVESTIGATION

At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases

(2015) Peter C. Grayson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly

(2015) Chris P. Verschoor et al.   MOLECULAR IMMUNOLOGY

Critical role of RAGE and HMGB1 in inflammatory heart disease

(2015) Anna Bangert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation

(2015) Miguel Angel Burguillos et al.   Cell Reports

Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice

(2015) Yangchen Dhondup et al.   PLoS One

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lprmice

(2014) Jason S Knight et al.   ANNALS OF THE RHEUMATIC DISEASES

von Willebrand Factor Directly Interacts With DNA From Neutrophil Extracellular Traps

(2014) S. Grassle et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The role of galectin-3 and galectin-3-binding protein in venous thrombosis

(2014) E. P. DeRoo et al.   BLOOD

The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via  2 integrins (CD11/CD18)

(2014) L. T. Weckbach et al.   BLOOD

Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

(2014) Jason S. Knight et al.   CIRCULATION RESEARCH

Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trial

(2014) Frank Edelmann et al.   EUROPEAN JOURNAL OF HEART FAILURE

C-reactive protein predicts mortality in patients referred for coronary angiography and symptoms of heart failure with preserved ejection fraction

(2014) L. Koller et al.   EUROPEAN JOURNAL OF HEART FAILURE

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor Progression Locus 2-dependent Oxidative Burst Drives Phosphorylation of Extracellular Signal-regulated Kinase during TLR3 and 9 Signaling

(2014) Teneema Kuriakose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis

(2014) Yunmei Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

(2014) Peter Huebener et al.   JOURNAL OF CLINICAL INVESTIGATION

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

(2014) N. Maugeri et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The effect of rosuvastatin on thromboinflammation in the setting of acute coronary syndrome

(2014) Travis R. Sexton et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

Induction of Atrial Fibrillation by Neutrophils Critically Depends on CD11b/CD18 Integrins

(2014) Kai Friedrichs et al.   PLoS One

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

(2014) Kathleen D. Metzler et al.   Cell Reports

Obesity, Subclinical Myocardial Injury, and Incident Heart Failure

(2014) Chiadi E. Ndumele et al.   JACC-Heart Failure

HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4

(2013) Jean-Marc Tadie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Midkine exacerbates pressure overload-induced cardiac remodeling

(2013) Shunsuke Netsu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice

(2013) A. S. Savchenko et al.   BLOOD

Cardiac nuclear high mobility group box 1 prevents the development of cardiac hypertrophy and heart failure

(2013) Akira Funayama et al.   CARDIOVASCULAR RESEARCH

Comparative Safety and Effectiveness of Metformin in Patients With Diabetes Mellitus and Heart Failure

(2013) Dean T. Eurich et al.   Circulation-Heart Failure

Primary blood neutrophils express a functional cell surface Toll-like receptor 9

(2013) Dennis Lindau et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Albumin oxidation leads to neutrophil activation in vitro and inaccurate measurement of serum albumin in patients with diabetic nephropathy

(2013) Regina Michelis et al.   FREE RADICAL BIOLOGY AND MEDICINE

Predictive value of serum galectin-3 levels in patients with acute heart failure with preserved ejection fraction

(2013) Francisco Javier Carrasco-Sánchez et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor

(2013) Hao Zhang et al.   JOURNAL OF LIPID RESEARCH

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

(2013) Walter J. Paulus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Toll-Like Receptor 9 Promotes Cardiac Inflammation and Heart Failure during Polymicrobial Sepsis

(2013) Ralph Lohner et al.   MEDIATORS OF INFLAMMATION

Galectin-3 is an independent marker for ventricular remodeling and mortality in patients with chronic heart failure

(2012) Dirk J. Lok et al.   Clinical Research in Cardiology

HMGB1 is an independent predictor of death and heart transplantation in heart failure

(2012) H. C. Volz et al.   Clinical Research in Cardiology

Neutrophil extracellular traps: Is immunity the second function of chromatin?

(2012) Volker Brinkmann et al.   JOURNAL OF CELL BIOLOGY

Galectin-3 Facilitates Neutrophil Recruitment as an Innate Immune Response to a Parasitic Protozoa Cutaneous Infection

(2012) P. Bhaumik et al.   JOURNAL OF IMMUNOLOGY

Galectin-3, a Marker of Cardiac Fibrosis, Predicts Incident Heart Failure in the Community

(2012) Jennifer E. Ho et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Effects of a Novel Pharmacologic Inhibitor of Myeloperoxidase in a Mouse Atherosclerosis Model

(2012) Cuiqing Liu et al.   PLoS One

Nucleic acid scavengers inhibit thrombosis without increasing bleeding

(2012) S. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study

(2012) Jon T Giles et al.   ARTHRITIS RESEARCH & THERAPY

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

(2012) Marc Leshner et al.   Frontiers in Immunology

Proteins derived from neutrophil extracellular traps may serve as self-antigens and mediate organ damage in autoimmune diseases

(2012) Jason S. Knight et al.   Frontiers in Immunology

Non-histone lysine acetylated proteins in heart failure

(2011) Jean Michel Grillon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Interrelationship Between Cardiac Hypertrophy, Heart Failure, and Chronic Kidney Disease

(2011) Jeffrey G. Dickhout et al.   CIRCULATION RESEARCH

Galectin-3 in Ambulatory Patients With Heart Failure

(2011) G. Michael Felker et al.   Circulation-Heart Failure

Myocarditis as a precipitating factor for heart failure: evaluation and 1-year follow-up using cardiovascular magnetic resonance and endomyocardial biopsy

(2011) Sophie Mavrogeni et al.   EUROPEAN JOURNAL OF HEART FAILURE

Premature Ligand-Receptor Interaction during Biosynthesis Limits the Production of Growth Factor Midkine and Its Receptor LDL Receptor-related Protein 1

(2011) Kazuma Sakamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis for the Interaction of Low Density Lipoprotein Receptor-related Protein 1 (LRP1) with Integrin αMβ2

(2011) Sripriya Ranganathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-α-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-l-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis

(2011) Van C. Willis et al.   JOURNAL OF IMMUNOLOGY

The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA*

(2011) S. H. Nymo et al.   JOURNAL OF INTERNAL MEDICINE

Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide

(2011) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Plasma calprotectin levels reflect disease severity in patients with chronic heart failure

(2011) Louise JN Jensen et al.   European Journal of Preventive Cardiology

Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction

(2010) Rudolf A. de Boer et al.   ANNALS OF MEDICINE

HMGB1: the missing link between diabetes mellitus and heart failure

(2010) H. Christian Volz et al.   BASIC RESEARCH IN CARDIOLOGY

Serum Midkine as a Predictor of Cardiac Events in Patients With Chronic Heart Failure

(2010) Tatsuro Kitahara et al.   JOURNAL OF CARDIAC FAILURE

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation

(2010) Volker Rudolph et al.   NATURE MEDICINE

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Usefulness of Neutrophil/Lymphocyte Ratio As Predictor of New-Onset Atrial Fibrillation After Coronary Artery Bypass Grafting

(2009) Patrick H. Gibson et al.   AMERICAN JOURNAL OF CARDIOLOGY

Effects of rosuvastatin on myeloperoxidase levels in patients with chronic heart failure: A randomized placebo-controlled study

(2009) Ioannis Andreou et al.   ATHEROSCLEROSIS

Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection

(2009) J. A. Van Ziffle et al.   BLOOD

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure

(2009) A. Yndestad et al.   EUROPEAN HEART JOURNAL

Neutrophil Infiltration and Systemic Vascular Inflammation in Obese Women

(2009) Tanvi J. Shah et al.   Reproductive Sciences

Usefulness of C-Reactive Protein and Left Ventricular Diastolic Performance for Prognosis in Patients With Left Ventricular Systolic Heart Failure

(2008) W.H. Wilson Tang et al.   AMERICAN JOURNAL OF CARDIOLOGY

Oxidative stress induces myeloperoxidase expression in endocardial endothelial cells from patients with chronic heart failure

(2008) Giampiero Rocca et al.   BASIC RESEARCH IN CARDIOLOGY

Receptor for advanced glycation end-products (RAGE) modulates neutrophil adhesion and migration on glycoxidated extracellular matrix

(2008) Fatouma Touré et al.   BIOCHEMICAL JOURNAL

High-mobility group box 1 restores cardiac function after myocardial infarction in transgenic mice

(2008) T. Kitahara et al.   CARDIOVASCULAR RESEARCH

High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart

(2008) Martin Andrassy et al.   CIRCULATION

Relationship between CD40 ligand expression and B type natriuretic peptide levels in patients with chronic heart failure

(2008) Jin-Chuan Yan et al.   CLINICA CHIMICA ACTA

Soluble CD40L, platelet surface CD40L and total platelet CD40L in congestive heart failure: relationship to platelet volume, mass and granularity

(2008) I. Chung et al.   JOURNAL OF INTERNAL MEDICINE

Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase

(2008) Robert Paul et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

(2008) Vered Elgazar-Carmon et al.   JOURNAL OF LIPID RESEARCH