Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice

Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats

(2015) Cameron G. McCarthy et al.   CARDIOVASCULAR RESEARCH

Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2

(2014) Y. Shintani et al.   EMBO REPORTS

Mitochondrial damage-associated molecular patterns and vascular function

(2014) C. F. Wenceslau et al.   EUROPEAN HEART JOURNAL

Toll-Like Receptor 9-Activation during Onset of Myocardial Ischemia Does Not Influence Infarct Extension

(2014) Ingrid Kristine Ohm et al.   PLoS One

Toll-Like Receptor 9 Mediated Responses in Cardiac Fibroblasts

(2014) Ingrid Kristine Ohm et al.   PLoS One

DAMPs and autophagy

(2013) Qiuhong Zhang et al.   Autophagy

Role of inflammation in the pathogenesis of heart failure with preserved ejection fraction and its potential as a therapeutic target

(2013) N. Glezeva et al.   HEART FAILURE REVIEWS

Increased Toll-like receptor 9 expression by B cells from inflammatory bowel disease patients

(2013) Drora Berkowitz et al.   HUMAN IMMUNOLOGY

CpG-ODN Attenuates Pathological Cardiac Hypertrophy and Heart Failure by Activation of PI3Kα-Akt Signaling

(2013) Liang Yang et al.   PLoS One

Priming with synthetic oligonucleotides attenuates pressure overload-induced inflammation and cardiac hypertrophy in mice

(2012) Markus Velten et al.   CARDIOVASCULAR RESEARCH

Improved MR phase-contrast velocimetry using a novel nine-point balanced motion-encoding scheme with increased robustness to eddy current effects

(2012) Emil K. S. Espe et al.   MAGNETIC RESONANCE IN MEDICINE

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Cardiac Sarcoplasmic Reticulum Calcium Leak: Basis and Roles in Cardiac Dysfunction

(2011) Donald M. Bers   Annual Review of Physiology

The Emerging Role of Innate Immunity in the Heart and Vascular System

(2011) Douglas L. Mann   CIRCULATION RESEARCH

Repeated TLR9 stimulation results in macrophage activation syndrome–like disease in mice

(2011) Edward M. Behrens et al.   JOURNAL OF CLINICAL INVESTIGATION

Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(αMHC-MerCreMer) mice

(2010) Karina Hougen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Epidemiology and risk profile of heart failure

(2010) Anh L. Bui et al.   Nature Reviews Cardiology

Heart Failure With Normal Ejection Fraction: The Complementary Roles of Echocardiography and CMR Imaging

(2010) Darryl P. Leong et al.   JACC-Cardiovascular Imaging

Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene

(2009) Kristin Brevik Andersson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sodium accumulation promotes diastolic dysfunction in end-stage heart failure followingSerca2knockout

(2009) William E. Louch et al.   JOURNAL OF PHYSIOLOGY-LONDON

Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of Toll-like receptor 9

(2008) P. Knuefermann et al.   CARDIOVASCULAR RESEARCH