Regulatory Role of Ubiquitin Specific Protease-13 (USP13) in Misfolded Protein Clearance in Neurodegenerative Diseases

Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34

(2020) Weihong Xie et al.   Cell Reports

The NEDD4-USP13 axis facilitates autophagy via deubiquitinating PIK3C3

(2020) Weihong Xie et al.   Autophagy

Knockdown of ubiquitin-specific peptidase 13 inhibits cell growth of hepatocellular carcinoma by reducing c-Myc expression

(2020) Jing Huang et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases

(2020) Alan J Fowler et al.   HUMAN MOLECULAR GENETICS

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Ubiquitin Signaling and Degradation of Aggregate-Prone Proteins

(2019) Margarita Galves et al.   TRENDS IN BIOCHEMICAL SCIENCES

Amplification of USP13 drives non-small cell lung cancer progression mediated by AKT/MAPK signaling

(2019) Yue Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy

(2019) Kaifeng Niu et al.   Autophagy

Ubiquitin Specific Protease 13 Regulates Tau Accumulation and Clearance in Models of Alzheimer’s Disease

(2019) Xiaoguang Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Universal stress proteins contribute Edwardsiella piscicida adversity resistance and pathogenicity and promote blocking host immune response

(2019) Qing-jian Fang et al.   FISH & SHELLFISH IMMUNOLOGY

Activating Autophagy as a Therapeutic Strategy for Parkinson’s Disease

(2018) Alan J. Fowler et al.   CNS DRUGS

Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through their deubiquitylating activities

(2018) Xuan Xie et al.   JOURNAL OF CELL SCIENCE

Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases

(2018) Charleen T. Chu   NEUROBIOLOGY OF DISEASE

Mass spectrometry analyses of normal and polyglutamine expanded ataxin-3 reveal novel interaction partners involved in mitochondrial function

(2018) Line V. Kristensen et al.   NEUROCHEMISTRY INTERNATIONAL

Diminished Parkin Solubility and Co-Localization with Intraneuronal Amyloid-β are Associated with Autophagic Defects in Alzheimer's Disease

(2018) Irina Lonskaya et al.   JOURNAL OF ALZHEIMERS DISEASE

Deubiquitinating Enzymes Related to Autophagy: New Therapeutic Opportunities?

(2018) Anne-Claire Jacomin et al.   Cells

Ubiquitin specific protease-13 independently regulates parkin ubiquitination and alpha-synuclein clearance in alpha-synucleinopathies

(2018) Xiaoguang Liu et al.   HUMAN MOLECULAR GENETICS

Microglial Interferon Signaling and White Matter

(2017) Ashley McDonough et al.   NEUROCHEMICAL RESEARCH

USP13 negatively regulates antiviral responses by deubiquitinating STING

(2017) He Sun et al.   Nature Communications

Neuropathological Staging of Brain Pathology in Sporadic Parkinson’s disease: Separating the Wheat from the Chaff

(2017) Heiko Braak et al.   Journal of Parkinsons Disease

The Dynamics and Turnover of Tau Aggregates in Cultured Cells

(2016) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBNand Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration

(2016) Dolores Del Prete et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination

(2016) Xiaoguang Fang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease

(2016) Zoi Alexopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amplification of USP13 drives ovarian cancer metabolism

(2016) Cecil Han et al.   Nature Communications

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement

(2015) Sarah N. Fontaine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of ubiquitin-specific processing protease 8 suppresses neuroinflammation

(2015) Lihong Zhu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways

(2015) Juliana Navarro-Yepes et al.   MOLECULAR NEUROBIOLOGY

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Parkin Is Dispensable for Mitochondrial Function, but Its Ubiquitin Ligase Activity Is Critical for Macroautophagy and Neurotransmitters: Therapeutic Potential beyond Parkinson's Disease

(2015) Charbel E.-H. Moussa   Neurodegenerative Diseases

Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer’s disease models

(2015) I. Lonskaya et al.   NEUROSCIENCE

Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity

(2015) Jung Hoon Lee et al.   Scientific Reports

Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease

(2015) Fouzi Magraoui et al.   Cells

Parkin-mediated K63-linked polyubiquitination: A signal for targeting misfolded proteins to the aggresome-autophagy pathway

(2014) James A. Olzmann et al.   Autophagy

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding

(2014) Katharina Flach et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

α-Synuclein Ubiquitination and Novel Therapeutic Targets for Parkinson’s Disease

(2014) Ruth Rott et al.   CNS & Neurological Disorders-Drug Targets

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

(2014) Anne-Laure Mahul-Mellier et al.   HUMAN MOLECULAR GENETICS

UBE2E Ubiquitin-conjugating Enzymes and Ubiquitin Isopeptidase Y Regulate TDP-43 Protein Ubiquitination

(2014) Friederike Hans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau deletion impairs intracellular β-amyloid-42 clearance and leads to more extracellular plaque deposition in gene transfer models

(2014) Irina Lonskaya et al.   Molecular Neurodegeneration

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease

(2014) Sian E. Davies et al.   NEUROBIOLOGY OF DISEASE

MicroRNA-135b regulates the stability of PTEN and promotes glycolysis by targeting USP13 in human colorectal cancers

(2014) SHIJUN XIANG et al.   ONCOLOGY REPORTS

Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance

(2013) Michaeline L. Hebron et al.   Autophagy

Could Dysregulation of UPS be a Common Underlying Mechanism for Cancer and Neurodegeneration? Lessons from UCHL1

(2013) Javier H. Jara et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance

(2013) Irina Lonskaya et al.   EMBO Molecular Medicine

Ubiquitin-Specific Protease 13 Regulates IFN Signaling by Stabilizing STAT1

(2013) H.-M. Yeh et al.   JOURNAL OF IMMUNOLOGY

Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance

(2013) Irina Lonskaya et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Deubiquitylation and stabilization of PTEN by USP13

(2013) Jinsong Zhang et al.   NATURE CELL BIOLOGY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Ubiquitination Increases Parkin Activity to Promote Autophagic α-Synuclein Clearance

(2013) Irina Lonskaya et al.   PLoS One

Synthetic polyubiquitinated  -Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology

(2013) M. Haj-Yahya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

(2013) E. S. Vincow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson’s disease

(2012) I. Lonskaya et al.   NEUROSCIENCE

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A  in AD models

(2011) P. J. Khandelwal et al.   HUMAN MOLECULAR GENETICS

Domain Analysis Reveals That a Deubiquitinating Enzyme USP13 Performs Non-Activating Catalysis for Lys63-Linked Polyubiquitin

(2011) Yu-Hang Zhang et al.   PLoS One

Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control

(2011) M. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity and Cellular Functions of the Deubiquitinating Enzyme and Polyglutamine Disease Protein Ataxin-3 Are Regulated by Ubiquitination at Lysine 117

(2010) Sokol V. Todi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Region-Specific Protein Abundance Changes in the Brain of MPTP-Induced Parkinson’s Disease Mouse Model

(2010) Xu Zhang et al.   JOURNAL OF PROTEOME RESEARCH

An Amyloid-Notch Hypothesis for Alzheimer’s Disease

(2010) Douglas W. Ethell   NEUROSCIENTIST

The relationship between parkin and protein aggregation in neurodegenerative diseases

(2010) Preeti Khandelwal   Frontiers in Psychiatry

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

The effects of parkin suppression on the behaviour, amyloid processing, and cell survival in APP mutant transgenic mice

(2009) Juan Perucho et al.   EXPERIMENTAL NEUROLOGY

Parkin promotes intracellular A 1-42 clearance

(2009) M. P. Burns et al.   HUMAN MOLECULAR GENETICS

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

(2009) Hui Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function

(2009) Kenneth M. Rosen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice

(2008) Jose A. Rodríguez-Navarro et al.   HUMAN MOLECULAR GENETICS

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE