Tau deletion impairs intracellular β-amyloid-42 clearance and leads to more extracellular plaque deposition in gene transfer models

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

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Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance

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Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance

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Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of  -synuclein in Parkinson's disease models

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Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance

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Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

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(2012) Claudia H. Kawas et al.   Alzheimers & Dementia

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

(2012) Erin E. Congdon et al.   Autophagy

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(2012) Daniel J. Klionsky et al.   Autophagy

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

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Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

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Alzheimer disease pathology and longitudinal cognitive performance in the oldest-old with no dementia

(2012) A. B. Balasubramanian et al.   NEUROLOGY

Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old

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Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A  in AD models

(2011) P. J. Khandelwal et al.   HUMAN MOLECULAR GENETICS

Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models

(2011) Preeti J. Khandelwal et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Autophagic degradation of tau in primary neurons and its enhancement by trehalose

(2011) Ulrike Krüger et al.   NEUROBIOLOGY OF AGING

β-Amyloid1–42Gene Transfer Model Exhibits Intraneuronal Amyloid, Gliosis, Tau Phosphorylation, and Neuronal Loss

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Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

(2010) Jose A. Rodríguez-Navarro et al.   NEUROBIOLOGY OF DISEASE

Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease

(2010) H.N. Dawson et al.   NEUROSCIENCE

An Amyloid-Notch Hypothesis for Alzheimer’s Disease

(2010) Douglas W. Ethell   NEUROSCIENTIST

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Tau normal function influences Niemann-Pick type C disease pathogenesis in mice and modulates autophagy in NPC1-deficient cells

(2009) Chris D. Pacheco et al.   Autophagy

Parkin promotes intracellular A 1-42 clearance

(2009) M. P. Burns et al.   HUMAN MOLECULAR GENETICS

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL