Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease

USP8 and PARK2/parkin-mediated mitophagy

(2015) Thomas M Durcan et al.   Autophagy

Deubiquitinating enzymes regulate PARK2-mediated mitophagy

(2015) Yuqing Wang et al.   Autophagy

Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy

(2015) Stefan Drießen et al.   Autophagy

Amino-terminal arginylation as a degradation signal for selective autophagy

(2015) Hyunjoo Cha-Molstad et al.   BMB Reports

AMBRA1 and BECLIN 1 interplay in the crosstalk between autophagy and cell proliferation

(2015) Valentina Cianfanelli et al.   CELL CYCLE

Atg1 family kinases in autophagy initiation

(2015) Nobuo N. Noda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

Emerging themes in bacterial autophagy

(2015) Matthew T Sorbara et al.   CURRENT OPINION IN MICROBIOLOGY

FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation

(2015) Juan Xiao et al.   GENES & DEVELOPMENT

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

(2015) Thomas M. Durcan et al.   GENES & DEVELOPMENT

Ral GTPases: crucial mediators of exocytosis and tumourigenesis

(2015) R. Shirakawa et al.   JOURNAL OF BIOCHEMISTRY

Phosphorylation of the Deubiquitinase USP20 by Protein Kinase A Regulates Post-endocytic Trafficking of β2Adrenergic Receptors to Autophagosomes during Physiological Stress

(2015) Reddy Peera Kommaddi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in cellular metabolism and cancer

(2015) Xuejun Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach

(2015) Jihoon Nah et al.   MOLECULES AND CELLS

USP30: A new promising target for Parkinson's disease?

(2015) S. Thobois   MOVEMENT DISORDERS

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

(2015) Keisuke Mochida et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

(2015) Christian N. Cunningham et al.   NATURE CELL BIOLOGY

The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc

(2015) Xiao-Xin Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1

(2015) Chunmin Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents α-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy

(2015) Katharina Pukaß et al.   Frontiers in Cellular Neuroscience

Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity

(2015) Masashi Kanayama et al.   Nature Communications

USP8 mutation in Cushing’s disease

(2015) Chuanxin Huang et al.   Oncotarget

Simultaneous inhibition of deubiquitinating enzymes (DUBs) and autophagy synergistically kills breast cancer cells

(2015) Rachel Isaksson Vogel et al.   Oncotarget

Autophagy in Mycobacterium tuberculosis and HIV infections

(2015) Lucile Espert et al.   Frontiers in Cellular and Infection Microbiology

Frequent Down Regulation of the Tumor Suppressor Gene A20 in Multiple Myeloma

(2015) Katharina Troppan et al.   PLoS One

Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases

(2014) Juha M.T. Hyttinen et al.   AGEING RESEARCH REVIEWS

Autophagosomes, phagosomes, autolysosomes, phagolysosomes, autophagolysosomes… Wait, I’m confused

(2014) Daniel J Klionsky et al.   Autophagy

Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability

(2014) Rohann J.M. Correa et al.   CARCINOGENESIS

Mitofusins: ubiquitylation promotes fusion

(2014) Mafalda Escobar-Henriques   CELL RESEARCH

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30

(2014) Wen Yue et al.   CELL RESEARCH

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

(2014) T. M. Durcan et al.   EMBO JOURNAL

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

(2014) Tom Cornelissen et al.   HUMAN MOLECULAR GENETICS

USP33 mediates Slit-Robo signaling in inhibiting colorectal cancer cell migration

(2014) Zhaohui Huang et al.   INTERNATIONAL JOURNAL OF CANCER

Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia

(2014) SHAN SHAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Beclin-1-p53 interaction is crucial for cell fate determination in embryonal carcinoma cells

(2014) Rakshamani Tripathi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Salmonella Secreted Factor L Deubiquitinase of Salmonella typhimurium Inhibits NF- B, Suppresses I B  Ubiquitination and Modulates Innate Immune Responses

(2014) G. Le Negrate et al.   JOURNAL OF IMMUNOLOGY

Inactivation of MYC reverses tumorigenesis

(2014) Y. Li et al.   JOURNAL OF INTERNAL MEDICINE

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

(2014) Valentina Cianfanelli et al.   NATURE CELL BIOLOGY

Mutations in the deubiquitinase gene USP8 cause Cushing's disease

(2014) Martin Reincke et al.   NATURE GENETICS

Bacteria–autophagy interplay: a battle for survival

(2014) Ju Huang et al.   NATURE REVIEWS MICROBIOLOGY

Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins

(2014) Daniel J Klionsky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ubiquitin-specific protease 22-induced autophagy is correlated with poor prognosis of pancreatic cancer

(2014) JIN-XIAO LIANG et al.   ONCOLOGY REPORTS

Ubiquitin Carboxyl Terminal Hydrolyase L1 -Suppressed Autophagic Degradation of p21WAF1/Cip1 as a Novel Feedback Mechanism in the Control of Cardiac Fibroblast Proliferation

(2014) Xiaoming Zhang et al.   PLoS One

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin and mitochondrial quality control: toward assembling the puzzle

(2014) Konstanze F. Winklhofer   TRENDS IN CELL BIOLOGY

The Biogenesis of Lysosomes and Lysosome-Related Organelles

(2014) J. P. Luzio et al.   Cold Spring Harbor Perspectives in Biology

USP33, a new player in lung cancer, mediates Slit-Robo signaling

(2014) Pushuai Wen et al.   Protein & Cell

β-adrenergic receptor responsiveness in aging heart and clinical implications

(2014) Nicola Ferrara et al.   Frontiers in Physiology

Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO

(2014) Christina Reidick et al.   Cancers

Versatile Roles of K63-Linked Ubiquitin Chains in Trafficking

(2014) Zoi Erpapazoglou et al.   Cells

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

Autophagy contributes to apoptosis in A20 and EL4 lymphoma cells treated with fluvastatin

(2013) Xu-Feng Qi et al.   Cancer Cell International

Autophagy-Mediated Tumor Promotion

(2013) Jessie Yanxiang Guo et al.   CELL

Inhibition of Protein Deubiquitination by PR-619 Activates the Autophagic Pathway in OLN-t40 Oligodendroglial Cells

(2013) Veronika Seiberlich et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

USP8 Is a Novel Target for Overcoming Gefitinib Resistance in Lung Cancer

(2013) S. Byun et al.   CLINICAL CANCER RESEARCH

WASH inhibits autophagy through suppression of Beclin 1 ubiquitination

(2013) Pengyan Xia et al.   EMBO JOURNAL

Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy

(2013) Hitoshi Nakatogawa   Essays in Biochemistry

A20-mediated negative regulation of canonical NF-κB signaling pathway

(2013) Rajeshree Pujari et al.   IMMUNOLOGIC RESEARCH

Beclin-1: Autophagic regulator and therapeutic target in cancer

(2013) Lei-lei Fu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO

(2013) Anne Kathrin Müller-Rischart et al.   MOLECULAR CELL

Autophagy: A critical regulator of cellular metabolism and homeostasis

(2013) Stefan W. Ryter et al.   MOLECULES AND CELLS

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110

(2013) Ji Li et al.   NATURE

ULK1 targets Beclin-1 in autophagy

(2013) Volodymyr Y. Nazarko et al.   NATURE CELL BIOLOGY

The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response

(2013) Michal Simicek et al.   NATURE CELL BIOLOGY

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Deubiquitylases From Genes to Organism

(2013) Michael J. Clague et al.   PHYSIOLOGICAL REVIEWS

The Deubiquitinating Enzyme AMSH1 and the ESCRT-III Subunit VPS2.1 Are Required for Autophagic Degradation in Arabidopsis

(2013) A. Katsiarimpa et al.   PLANT CELL

Lack of Effect of the Salmonella Deubiquitinase SseL on the NF-κB Pathway

(2013) Francisco S. Mesquita et al.   PLoS One

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

(2013) E. S. Vincow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Emerging roles of E3 ubiquitin ligases in autophagy

(2013) Ersheng Kuang et al.   TRENDS IN BIOCHEMICAL SCIENCES

The DUB-ious lack of ALIS in Salmonella infection

(2012) Mair Thomas et al.   Autophagy

The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins

(2012) Emmanuel Taillebourg et al.   Autophagy

Ubiquitination and selective autophagy

(2012) S Shaid et al.   CELL DEATH AND DIFFERENTIATION

Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression

(2012) Hilde Abrahamsen et al.   FEBS LETTERS

Ubiquitination in signaling to and activation of IKK

(2012) Zhijian J. Chen   IMMUNOLOGICAL REVIEWS

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism

(2012) D. Narendra et al.   Cold Spring Harbor Perspectives in Biology

Host–Pathogen Interaction in Invasive Salmonellosis

(2012) Hanna K. de Jong et al.   PLoS Pathogens

The Salmonella Deubiquitinase SseL Inhibits Selective Autophagy of Cytosolic Aggregates

(2012) Francisco S. Mesquita et al.   PLoS Pathogens

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

(2011) Dun-Sheng Yang et al.   Autophagy

Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway

(2011) Paul Waltz et al.   Autophagy

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

(2011) Antje S. Löffler et al.   Autophagy

AMSH is required to degrade ubiquitinated proteins in the central nervous system

(2011) Shunya Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1

(2011) Harald W. Platta et al.   BIOCHEMICAL JOURNAL

RalB and the Exocyst Mediate the Cellular Starvation Response by Direct Activation of Autophagosome Assembly

(2011) Brian O. Bodemann et al.   CELL

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy is normally inactivated by A20

(2011) Megumi Inomata et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endocytosis and signaling

(2011) Harald W Platta et al.   CURRENT OPINION IN CELL BIOLOGY

Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases

(2011) Mariola J. Edelmann et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A  in AD models

(2011) P. J. Khandelwal et al.   HUMAN MOLECULAR GENETICS

Ubp15p, a Ubiquitin Hydrolase Associated with the Peroxisomal Export Machinery

(2011) Mykhaylo O. Debelyy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis

(2011) Gianna Elena Hammer et al.   NATURE IMMUNOLOGY

TheArabidopsisDeubiquitinating Enzyme AMSH3 Interacts with ESCRT-III Subunits and Regulates Their Localization

(2011) Anthi Katsiarimpa et al.   PLANT CELL

Beclin 1 Complex in Autophagy and Alzheimer Disease

(2010) Philipp A. Jaeger et al.   ARCHIVES OF NEUROLOGY

NDP52, a novel autophagy receptor for ubiquitin-decorated cytosolic bacteria

(2010) Natalia von Muhlinen et al.   Autophagy

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

(2010) Terje Høyvarde Clausen et al.   Autophagy

Traf6 and A20 differentially regulate TLR4-Induced autophagy by affecting the ubiquitination of Beclin 1

(2010) Chong-Shan Shi et al.   Autophagy

USP10: Friend and Foe

(2010) Aart G. Jochemsen et al.   CELL

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

(2010) Jian Yuan et al.   CELL

A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic

(2010) Sigrid B. Thoresen et al.   EXPERIMENTAL CELL RESEARCH

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

(2010) Kei Okatsu et al.   GENES TO CELLS

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

The Machado–Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability

(2010) Thomas M. Durcan et al.   HUMAN MOLECULAR GENETICS

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

(2010) Sabrina Di Bartolomeo et al.   JOURNAL OF CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

The Deubiquitinating Enzyme AMSH3 Is Required for Intracellular Trafficking and Vacuole Biogenesis inArabidopsis thaliana

(2010) Erika Isono et al.   PLANT CELL

Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex

(2010) Philipp A. Jaeger et al.   PLoS One

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRAF6 and A20 Regulate Lysine 63-Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy

(2010) C. S. Shi et al.   Science Signaling

Autophagy defects contribute to neurodegeneration induced by dysfunctional ESCRT-III

(2009) Jin-A Lee et al.   Autophagy

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

The deubiquitinases USP33 and USP20 coordinate β2 adrenergic receptor recycling and resensitization

(2009) Magali Berthouze et al.   EMBO JOURNAL

How do ESCRT proteins control autophagy?

(2009) T. E. Rusten et al.   JOURNAL OF CELL SCIENCE

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

(2009) Mara Compagno et al.   NATURE

Frequent inactivation of A20 in B-cell lymphomas

(2009) Motohiro Kato et al.   NATURE

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

(2009) Lars Vereecke et al.   TRENDS IN IMMUNOLOGY

Structural Basis for Ubiquitin Recognition by the Otu1 Ovarian Tumor Domain Protein

(2008) Troy Eugene Messick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nedd4 Mediates Agonist-dependent Ubiquitination, Lysosomal Targeting, and Degradation of the β2-Adrenergic Receptor

(2008) Sudha K. Shenoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages

(2008) Chong-Shan Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

(2008) Fiona Pickford et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Aβ pathology by beclin 1: a protective role for autophagy?

(2008) Jin-A Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Mitochondrial Morphology by USP30, a Deubiquitinating Enzyme Present in the Mitochondrial Outer Membrane

(2008) Nobuhiro Nakamura et al.   MOLECULAR BIOLOGY OF THE CELL

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

(2008) Robert R Graham et al.   NATURE GENETICS

Structure of the A20 OTU domain and mechanistic insights into deubiquitination

(2007) David Komander et al.   BIOCHEMICAL JOURNAL