Ubiquitin Specific Protease 13 Regulates Tau Accumulation and Clearance in Models of Alzheimer’s Disease

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through their deubiquitylating activities

(2018) Xuan Xie et al.   JOURNAL OF CELL SCIENCE

Tau clearance improves astrocytic function and brain glutamate-glutamine cycle

(2018) Michaeline L. Hebron et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory

(2018) Misato Yoshikawa et al.   Frontiers in Neuroscience

Diminished Parkin Solubility and Co-Localization with Intraneuronal Amyloid-β are Associated with Autophagic Defects in Alzheimer's Disease

(2018) Irina Lonskaya et al.   JOURNAL OF ALZHEIMERS DISEASE

Ubiquitin specific protease-13 independently regulates parkin ubiquitination and alpha-synuclein clearance in alpha-synucleinopathies

(2018) Xiaoguang Liu et al.   HUMAN MOLECULAR GENETICS

Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy

(2017) Monica Javidnia et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglial Interferon Signaling and White Matter

(2017) Ashley McDonough et al.   NEUROCHEMICAL RESEARCH

The Dynamics and Turnover of Tau Aggregates in Cultured Cells

(2016) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBNand Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration

(2016) Dolores Del Prete et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease

(2016) Zoi Alexopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer’s-Like Pathological Features in Mice

(2016) Kaushik Ghosal et al.   PLoS One

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement

(2015) Sarah N. Fontaine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of ubiquitin-specific processing protease 8 suppresses neuroinflammation

(2015) Lihong Zhu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways

(2015) Juliana Navarro-Yepes et al.   MOLECULAR NEUROBIOLOGY

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer’s disease models

(2015) I. Lonskaya et al.   NEUROSCIENCE

Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity

(2015) Jung Hoon Lee et al.   Scientific Reports

Parkin-mediated K63-linked polyubiquitination: A signal for targeting misfolded proteins to the aggresome-autophagy pathway

(2014) James A. Olzmann et al.   Autophagy

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding

(2014) Katharina Flach et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

α-Synuclein Ubiquitination and Novel Therapeutic Targets for Parkinson’s Disease

(2014) Ruth Rott et al.   CNS & Neurological Disorders-Drug Targets

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

(2014) Anne-Laure Mahul-Mellier et al.   HUMAN MOLECULAR GENETICS

UBE2E Ubiquitin-conjugating Enzymes and Ubiquitin Isopeptidase Y Regulate TDP-43 Protein Ubiquitination

(2014) Friederike Hans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau deletion impairs intracellular β-amyloid-42 clearance and leads to more extracellular plaque deposition in gene transfer models

(2014) Irina Lonskaya et al.   Molecular Neurodegeneration

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease

(2014) Sian E. Davies et al.   NEUROBIOLOGY OF DISEASE

Could Dysregulation of UPS be a Common Underlying Mechanism for Cancer and Neurodegeneration? Lessons from UCHL1

(2013) Javier H. Jara et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance

(2013) Irina Lonskaya et al.   EMBO Molecular Medicine

Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance

(2013) Irina Lonskaya et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Ubiquitination Increases Parkin Activity to Promote Autophagic α-Synuclein Clearance

(2013) Irina Lonskaya et al.   PLoS One

Synthetic polyubiquitinated  -Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology

(2013) M. Haj-Yahya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

(2013) E. S. Vincow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion

(2012) Kohei Shimada et al.   NEUROBIOLOGY OF DISEASE

Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson’s disease

(2012) I. Lonskaya et al.   NEUROSCIENCE

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A  in AD models

(2011) P. J. Khandelwal et al.   HUMAN MOLECULAR GENETICS

USP13 Enzyme Regulates Siah2 Ligase Stability and Activity via Noncatalytic Ubiquitin-binding Domains

(2011) Marzia Scortegagna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of MITF stability by the USP13 deubiquitinase

(2011) Xiansi Zhao et al.   Nature Communications

Ubiquitin: Same Molecule, Different Degradation Pathways

(2010) Michael J. Clague et al.   CELL

Region-Specific Protein Abundance Changes in the Brain of MPTP-Induced Parkinson’s Disease Mouse Model

(2010) Xu Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

An Amyloid-Notch Hypothesis for Alzheimer’s Disease

(2010) Douglas W. Ethell   NEUROSCIENTIST

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE