Could Dysregulation of UPS be a Common Underlying Mechanism for Cancer and Neurodegeneration? Lessons from UCHL1

Enzymes of ubiquitination and deubiquitination

(2014) Melanie Neutzner et al.   Essays in Biochemistry

Frequent CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in sporadic and hereditary Tunisian breast cancer patients: clinical significance

(2013) Fatma Trifa et al.   MEDICAL ONCOLOGY

The Ubiquitin System, an Immense Realm

(2012) Alexander Varshavsky   Annual Review of Biochemistry

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

The Ubiquitin+Proteasome Protein Degradation Pathway as a Therapeutic Strategy in the Treatment of Solid Tumor Malignancies

(2012) James J. Driscoll et al.   Anti-Cancer Agents in Medicinal Chemistry

Ubiquitin C-terminal hydrolase-L1 interacts with adhesion complexes and promotes cell migration, survival, and anchorage independent growth

(2012) Teresa Frisan et al.   FASEB JOURNAL

Proteasome deubiquitinases as novel targets for cancer therapy

(2012) Pádraig D’Arcy et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Comprehensive profiling of proteome changes upon sequential deletion of deubiquitylating enzymes

(2012) Jon W. Poulsen et al.   Journal of Proteomics

E3 Ubiquitin Ligases in Protein Quality Control Mechanism

(2012) Deepak Chhangani et al.   MOLECULAR NEUROBIOLOGY

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

The Ubiquitin Peptidase UCHL1 Induces G0/G1 Cell Cycle Arrest and Apoptosis Through Stabilizing p53 and Is Frequently Silenced in Breast Cancer

(2012) Tingxiu Xiang et al.   PLoS One

SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2011) Faisal Fecto   ARCHIVES OF NEUROLOGY

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

(2011) Mikael Altun et al.   CHEMISTRY & BIOLOGY

The Ubiquitin-Proteasome System (UPS) and the Mechanism of Action of Bortezomib

(2011) Boris Cvek et al.   CURRENT PHARMACEUTICAL DESIGN

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen and Angiogenin Interact with Common Host Proteins, Including Annexin A2, Which Is Essential for Survival of Latently Infected Cells

(2011) N. Paudel et al.   JOURNAL OF VIROLOGY

Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation

(2011) Ramesh Ummanni et al.   Molecular Cancer

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

(2011) Han-Xiang Deng et al.   NATURE

The new landscape of protein ubiquitination

(2011) Guoqiang Xu et al.   NATURE BIOTECHNOLOGY

Small-fiber neuropathy in patients with ALS

(2011) J. Weis et al.   NEUROLOGY

The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress

(2011) T Rzymski et al.   ONCOGENE

Balancing act: deubiquitinating enzymes in the nervous system

(2011) Sokol V. Todi et al.   TRENDS IN NEUROSCIENCES

The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery?

(2010) Martin McLaughlin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) regulates the level of SMN expression through ubiquitination in primary spinal muscular atrophy fibroblasts

(2010) Shih-Hsien Hsu et al.   CLINICA CHIMICA ACTA

The Tumor Suppressor UCHL1 Forms a Complex with p53/MDM2/ARF to Promote p53 Signaling and Is Frequently Silenced in Nasopharyngeal Carcinoma

(2010) L. Li et al.   CLINICAL CANCER RESEARCH

An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1

(2010) Mercedes Prudencio et al.   HUMAN MOLECULAR GENETICS

Trimming of Ubiquitin Chains by Proteasome-associated Deubiquitinating Enzymes

(2010) Min Jae Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

(2010) Daryl A Bosco et al.   NATURE NEUROSCIENCE

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

Transgenic Expression of the Amyloid-β Precursor Protein-Intracellular Domain Does Not Induce Alzheimer's Disease–Like Traits In Vivo

(2010) Luca Giliberto et al.   PLoS One

Modelling the Role of UCH-L1 on Protein Aggregation in Age-Related Neurodegeneration

(2010) Carole J. Proctor et al.   PLoS One

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

A fragment of the scaffolding protein RanBP9 is increased in Alzheimer’s disease brains and strongly potentiates amyloid-β peptide generation

(2009) Madepalli K. Lakshmana et al.   FASEB JOURNAL

Regulation of Synaptic Structure by Ubiquitin C-Terminal Hydrolase L1

(2009) A. E. Cartier et al.   JOURNAL OF NEUROSCIENCE

Positive Reciprocal Regulation of Ubiquitin C-Terminal Hydrolase L1 and β-Catenin/TCF Signaling

(2009) Anjali Bheda et al.   PLoS One

Expression and Functional Studies of Ubiquitin C-Terminal Hydrolase L1 Regulated Genes

(2009) Anjali Bheda et al.   PLoS One

UCHL1 (PGP 9.5): Neuronal biomarker and ubiquitin system protein

(2009) Ian N.M. Day et al.   PROGRESS IN NEUROBIOLOGY

Regulation of Epidermal Growth Factor Receptor Trafficking by Lysine Deacetylase HDAC6

(2009) Y. Lissanu Deribe et al.   Science Signaling

Aberrant molecular properties shared by familial Parkinson’s disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1

(2008) Tomohiro Kabuta et al.   HUMAN MOLECULAR GENETICS

Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity

(2008) B.J. Walters et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

VAPB: New genetic clues to the pathogenesis of ALS

(2008) M. Hirano   NEUROLOGY

Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis

(2008) H J Kim et al.   ONCOGENE