Cell-based strategies for IVD repair: clinical progress and translational obstacles
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Title
Cell-based strategies for IVD repair: clinical progress and translational obstacles
Authors
Keywords
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Journal
Nature Reviews Rheumatology
Volume 17, Issue 3, Pages 158-175
Publisher
Springer Science and Business Media LLC
Online
2021-02-01
DOI
10.1038/s41584-020-00568-w
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Note: Only part of the references are listed.- Mesenchymal stem cells from different sources and their derived exosomes: A pre-clinical perspective
- (2020) María Álvarez-Viejo World Journal of Stem Cells
- Sustained Release of GDF5 from a Designed Coacervate Attenuates Disc Degeneration in a Rat Model
- (2019) Jian Zhu et al. Acta Biomaterialia
- Microfluidic Disc-on-a-Chip Device for Mouse Intervertebral Disc—Pitching a Next-Generation Research Platform To Study Disc Degeneration
- (2019) Jun Dai et al. ACS Biomaterials-Science & Engineering
- Autologous mesenchymal stromal cells embedded in tricalcium phosphate for posterolateral spinal fusion: results of a prospective phase I/II clinical trial with long-term follow-up
- (2019) Juan F. Blanco et al. Stem Cell Research & Therapy
- Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury
- (2019) Zheng Gang Zhang et al. Nature Reviews Neurology
- A new understanding of the role of IL‐1 in age‐related intervertebral disc degeneration in a murine model
- (2019) Deborah J. Gorth et al. JOURNAL OF BONE AND MINERAL RESEARCH
- The next generation of CRISPR–Cas technologies and applications
- (2019) Adrian Pickar-Oliver et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Advances in therapeutic applications of extracellular vesicles
- (2019) Oscar P. B. Wiklander et al. Science Translational Medicine
- Hypoxic Preconditioning Enhances Bone Marrow–Derived Mesenchymal Stem Cell Survival in a Low Oxygen and Nutrient-Limited 3D Microenvironment
- (2019) Sun H. Peck et al. Cartilage
- Intra-articularly injected mesenchymal stem cells promote cartilage regeneration, but do not permanently engraft in distant organs
- (2019) María Satué et al. Scientific Reports
- Treatment of Intervertebral Disk Disease by the Administration of mRNA Encoding a Cartilage-Anabolic Transcription Factor
- (2019) Chin-Yu Lin et al. Molecular Therapy-Nucleic Acids
- Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects
- (2019) Chen Xia et al. FREE RADICAL BIOLOGY AND MEDICINE
- Extracellular vesicles as modulators of wound healing
- (2018) Joana Cabral et al. ADVANCED DRUG DELIVERY REVIEWS
- Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice
- (2018) Guo-Hong Cui et al. FASEB JOURNAL
- Nerves and blood vessels in degenerated intervertebral discs are confined to physically disrupted tissue
- (2018) Polly Lama et al. JOURNAL OF ANATOMY
- The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke
- (2018) Catriona J Cunningham et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- A multicenter, randomized, double-blind, dose-finding study of condoliase in patients with lumbar disc herniation
- (2018) Yukihiro Matsuyama et al. JOURNAL OF NEUROSURGERY-SPINE
- Prevention and treatment of low back pain: evidence, challenges, and promising directions
- (2018) Nadine E Foster et al. LANCET
- What low back pain is and why we need to pay attention
- (2018) Jan Hartvigsen et al. LANCET
- Low back pain: a call for action
- (2018) Rachelle Buchbinder et al. LANCET
- Immunomodulation of Human Mesenchymal Stem/Stromal Cells in Intervertebral Disc Degeneration
- (2018) Graciosa Q. Teixeira et al. SPINE
- Immunomodulation By Therapeutic Mesenchymal Stromal Cells (MSC) Is Triggered Through Phagocytosis of MSC By Monocytic Cells
- (2018) Samantha F.H. de Witte et al. STEM CELLS
- Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells
- (2018) Ruhang Tang et al. Stem Cell Research & Therapy
- Timing of Intra-Articular Injection of Synovial Mesenchymal Stem Cells Affects Cartilage Restoration in a Partial Thickness Cartilage Defect Model in Rats
- (2018) Takahiro Enomoto et al. Cartilage
- Annulus fibrosus cell phenotypes in homeostasis and injury: implications for regenerative strategies
- (2018) Olivia M. Torre et al. Annals of the New York Academy of Sciences
- Treatment of Naturally Degenerated Canine Lumbosacral Intervertebral Discs with Autologous Mesenchymal Stromal Cells and Collagen Microcarriers: A Prospective Clinical Study
- (2018) Frank Steffen et al. CELL TRANSPLANTATION
- Mesenchymal Stem Cell-Seeded High-Density Collagen Gel for Annular Repair: 6-Week Results From In Vivo Sheep Models
- (2018) Ibrahim Hussain et al. NEUROSURGERY
- Mesenchymal stem cells deliver exogenous miR-21 via exosomes to inhibit nucleus pulposus cell apoptosis and reduce intervertebral disc degeneration
- (2017) Xiaofei Cheng et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- New horizons in spine research: Intervertebral disc repair and regeneration
- (2017) James C. Iatridis et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy
- (2017) Christopher Centeno et al. Journal of Translational Medicine
- CRISPR Epigenome Editing of AKAP150 in DRG Neurons Abolishes Degenerative IVD-Induced Neuronal Activation
- (2017) Joshua D. Stover et al. MOLECULAR THERAPY
- Single-stage cell-based cartilage repair in a rabbit model: cell tracking and in vivo chondrogenesis of human umbilical cord blood-derived mesenchymal stem cells and hyaluronic acid hydrogel composite
- (2017) Y.B. Park et al. OSTEOARTHRITIS AND CARTILAGE
- Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation
- (2017) Antonio Galleu et al. Science Translational Medicine
- The Need for Multidimensional Stratification of Chronic Low Back Pain (LBP)
- (2017) Yoga Raja Rampersaud et al. SPINE
- Intervertebral Disc Repair by Allogeneic Mesenchymal Bone Marrow Cells
- (2017) David C. Noriega et al. TRANSPLANTATION
- Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study
- (2017) Hemant Kumar et al. Stem Cell Research & Therapy
- Exosomes as potential alternatives to stem cell therapy for intervertebral disc degeneration: in-vitro study on exosomes in interaction of nucleus pulposus cells and bone marrow mesenchymal stem cells
- (2017) Kang Lu et al. Stem Cell Research & Therapy
- Cell-based therapies for intervertebral disc and cartilage regeneration- Current concepts, parallels, and perspectives
- (2016) Srujana Vedicherla et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Intra-discal injection of autologous, hypoxic cultured bone marrow-derived mesenchymal stem cells in five patients with chronic lower back pain: a long-term safety and feasibility study
- (2016) Christian Elabd et al. Journal of Translational Medicine
- A prospective randomized multicenter phase I/II clinical trial to evaluate safety and efficacy of NOVOCART disk plus autologous disk chondrocyte transplantation in the treatment of nucleotomized and degenerative lumbar disks to avoid secondary disease: safety results of Phase I—a short report
- (2016) Anja Tschugg et al. NEUROSURGICAL REVIEW
- The Effect of Substance P on an Intervertebral Disc Rat Organ Culture Model
- (2016) John D. Koerner et al. SPINE
- Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo
- (2016) Alon Lai et al. Spine Journal
- Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomal MicroRNAs Suppress Myofibroblast Differentiation by Inhibiting the Transforming Growth Factor-β/SMAD2 Pathway During Wound Healing
- (2016) Shuo Fang et al. Stem Cells Translational Medicine
- Skeletal stem cells
- (2015) P. Bianco et al. DEVELOPMENT
- Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting
- (2015) Makarand V. Risbud et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Stem cell therapy for intervertebral disc regeneration: obstacles and solutions
- (2015) Daisuke Sakai et al. Nature Reviews Rheumatology
- Potential roles of cytokines and chemokines in human intervertebral disc degeneration: interleukin-1 is a master regulator of catabolic processes
- (2015) K.L.E. Phillips et al. OSTEOARTHRITIS AND CARTILAGE
- Substance P Receptor Antagonist Suppresses Inflammatory Cytokine Expression in Human Disc Cells
- (2015) Christopher K. Kepler et al. SPINE
- Nerves are more abundant than blood vessels in the degenerate human intervertebral disc
- (2015) Abbie L. A. Binch et al. ARTHRITIS RESEARCH & THERAPY
- Nucleus pulposus phenotypic markers to determine stem cell differentiation: fact or fiction?
- (2015) Abbey A. Thorpe et al. Oncotarget
- In Vivo Therapeutic Potential of Mesenchymal Stromal Cells Depends on the Source and the Isolation Procedure
- (2015) Francesca Bortolotti et al. Stem Cell Reports
- Reflecting on the global burden of musculoskeletal conditions: lessons learnt from the Global Burden of Disease 2010 Study and the next steps forward
- (2014) Damian G Hoy et al. ANNALS OF THE RHEUMATIC DISEASES
- The global burden of low back pain: estimates from the Global Burden of Disease 2010 study
- (2014) Damian Hoy et al. ANNALS OF THE RHEUMATIC DISEASES
- Painful, degenerating intervertebral discs up-regulate neurite sprouting and CGRP through nociceptive factors
- (2014) Emerson Krock et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs
- (2014) Qingguo Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ISSLS Prize Winner
- (2014) Masayuki Miyagi et al. SPINE
- Percutaneous Injection of Autologous Bone Marrow Concentrate Cells Significantly Reduces Lumbar Discogenic Pain Through 12 Months
- (2014) Kenneth A. Pettine et al. STEM CELLS
- FasL Gene -844T/C Mutation of Esophageal Cancer in South China and Its Clinical Significance
- (2014) Hongguang Zhao et al. Scientific Reports
- A role for TNFα in intervertebral disc degeneration: A non-recoverable catabolic shift
- (2013) D. Purmessur et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT)
- (2013) Philippe Bourin et al. CYTOTHERAPY
- Substance P Stimulates Production of Inflammatory Cytokines in Human Disc Cells
- (2013) Christopher K. Kepler et al. SPINE
- Genetic polymorphisms associated with intervertebral disc degeneration
- (2013) Jillian E. Mayer et al. Spine Journal
- The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc
- (2013) Kate L E Phillips et al. ARTHRITIS RESEARCH & THERAPY
- Notochordal Cells in the Adult Intervertebral Disc: New Perspective on an Old Question
- (2012) Makarand V. Risbud et al. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
- Prospective study of disc repair with allogeneic chondrocytes Presented at the 2012 Joint Spine Section Meeting
- (2012) Domagoj Coric et al. JOURNAL OF NEUROSURGERY-SPINE
- Annulus Fissures Are Mechanically and Chemically Conducive to the Ingrowth of Nerves and Blood Vessels
- (2012) Manos Stefanakis et al. SPINE
- The Presence of Local Mesenchymal Progenitor Cells in Human Degenerated Intervertebral Discs and Possibilities to Influence These In Vitro: A Descriptive Study in Humans
- (2012) Helena Brisby et al. STEM CELLS AND DEVELOPMENT
- Intervertebral disc degeneration in the dog. Part 2: Chondrodystrophic and non-chondrodystrophic breeds
- (2012) Lucas A. Smolders et al. VETERINARY JOURNAL
- Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
- (2012) Daisuke Sakai et al. Nature Communications
- Adalimumab in acute sciatica reduces the long-term need for surgery: a 3-year follow-up of a randomised double-blind placebo-controlled trial
- (2011) S Genevay et al. ANNALS OF THE RHEUMATIC DISEASES
- Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development
- (2011) M. R. McCann et al. Disease Models & Mechanisms
- Investigation of transport and unpacking mechanisms of polyplexes for transfection efficacy on different cell lines
- (2011) G. A. Trusov et al. Doklady Biochemistry and Biophysics
- Innervation patterns of PGP 9.5-positive nerve fibers within the human lumbar vertebra
- (2011) Jeannie F. Bailey et al. JOURNAL OF ANATOMY
- Mesenchymal stem cells injection in degenerated intervertebral disc: cell leakage may induce osteophyte formation
- (2011) Gianluca Vadalà et al. Journal of Tissue Engineering and Regenerative Medicine
- Intervertebral Disc Repair by Autologous Mesenchymal Bone Marrow Cells: A Pilot Study
- (2011) Lluis Orozco et al. TRANSPLANTATION
- Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation
- (2010) Ben M. Minogue et al. ARTHRITIS AND RHEUMATISM
- GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women
- (2010) F. M. K. Williams et al. ARTHRITIS AND RHEUMATISM
- Toward an understanding of the role of notochordal cells in the adult intervertebral disc: From discord to accord
- (2010) Makarand V. Risbud et al. DEVELOPMENTAL DYNAMICS
- Proteomic Analysis of Tumor Necrosis Factor-α-Induced Secretome of Human Adipose Tissue-Derived Mesenchymal Stem Cells
- (2010) Mi Jeong Lee et al. JOURNAL OF PROTEOME RESEARCH
- Co-culture induces mesenchymal stem cell differentiation and modulation of the degenerate human nucleus pulposus cell phenotype
- (2010) Sandra Strassburg et al. Regenerative Medicine
- Disc Regeneration Therapy Using Marrow Mesenchymal Cell Transplantation
- (2010) Takafumi Yoshikawa et al. SPINE
- Differential expression level of cytokeratin 8 in cells of the bovine nucleus pulposus complicates the search for specific intervertebral disc cell markers
- (2010) Audrey Gilson et al. ARTHRITIS RESEARCH & THERAPY
- Human Disk Cells from Degenerated Disks and Mesenchymal Stem Cells in Co-Culture Result in Increased Matrix Production
- (2009) T. Svanvik et al. CELLS TISSUES ORGANS
- Methods to monitor distribution and metabolic activity of mesenchymal stem cells following in vivo injection into nucleotomized porcine intervertebral discs
- (2009) G. W. Omlor et al. EUROPEAN SPINE JOURNAL
- Human nucleus pulposus cells significantly enhanced biological properties in a coculture system with direct cell-to-cell contact with autologous mesenchymal stem cells
- (2009) Takuya Watanabe et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury
- (2009) S. Bruno et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Coculture of Bone Marrow Mesenchymal Stem Cells and Nucleus Pulposus Cells Modulate Gene Expression Profile Without Cell Fusion
- (2009) Gianluca Vadalà et al. SPINE
- Intervertebral Disc Repair Using Adipose Tissue-Derived Stem and Regenerative Cells
- (2009) Timothy Ganey et al. SPINE
- Interventional Therapies, Surgery, and Interdisciplinary Rehabilitation for Low Back Pain
- (2009) Roger Chou et al. SPINE
- Cell transplantation in lumbar spine disc degeneration disease
- (2008) C. Hohaus et al. EUROPEAN SPINE JOURNAL
- Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc
- (2008) J. A. Hoyland et al. RHEUMATOLOGY
- In Vitro Study on Interaction Between Human Nucleus Pulposus Cells and Mesenchymal Stem Cells Through Paracrine Stimulation
- (2008) Shu-Hua Yang et al. SPINE
- A systematic review of low back pain cost of illness studies in the United States and internationally
- (2008) Simon Dagenais et al. Spine Journal
- Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc
- (2008) Devina Purmessur et al. ARTHRITIS RESEARCH & THERAPY
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