Intra-discal injection of autologous, hypoxic cultured bone marrow-derived mesenchymal stem cells in five patients with chronic lower back pain: a long-term safety and feasibility study
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Title
Intra-discal injection of autologous, hypoxic cultured bone marrow-derived mesenchymal stem cells in five patients with chronic lower back pain: a long-term safety and feasibility study
Authors
Keywords
Regenerative medicine, Cell therapy, Degenerative disc disease, Autologous, Hypoxic, Mesenchymal stem cells, Bone marrow, Intra-discal injection, Safety, Feasibility
Journal
Journal of Translational Medicine
Volume 14, Issue 1, Pages -
Publisher
Springer Nature
Online
2016-09-03
DOI
10.1186/s12967-016-1015-5
References
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- Hypoxia mediated isolation and expansion enhances the chondrogenic capacity of bone marrow mesenchymal stromal cells
- (2012) Adetola B Adesida et al. Stem Cell Research & Therapy
- Safety and Complications Reporting Update on the Re-Implantation of Culture-Expanded Mesenchymal Stem Cells Using Autologous Platelet Lysate Technique
- (2012) Christopher J. Centeno et al. Current Stem Cell Research & Therapy
- Hypoxic Regulation of Nucleus Pulposus Cell Survival
- (2010) Makarand V. Risbud et al. AMERICAN JOURNAL OF PATHOLOGY
- Synthesis of recommendations for the assessment and management of low back pain from recent clinical practice guidelines
- (2010) Simon Dagenais et al. Spine Journal
- Recent advances in annular pathobiology provide insights into rim-lesion mediated intervertebral disc degeneration and potential new approaches to annular repair strategies
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