Mesenchymal stem cells deliver exogenous miR-21 via exosomes to inhibit nucleus pulposus cell apoptosis and reduce intervertebral disc degeneration

Mesenchymal stem cell–derived extracellular vesicles attenuate kidney inflammation

(2017) Alfonso Eirin et al.   KIDNEY INTERNATIONAL

Stem Cell Delivery with Polymer Hydrogel for Treatment of Intervertebral Disc Degeneration: From 3D Culture to Design of the Delivery Device for Minimally Invasive Therapy

(2016) Deepak Kumar et al.   CELL TRANSPLANTATION

Autogenous Mesenchymal Stem Cells from the Vertebral Body Enhance Intervertebral Disc Regeneration via Paracrine Interaction: An in Vitro Pilot Study

(2016) Eun-Kyung Shim et al.   CELL TRANSPLANTATION

MiR-125a Rs12976445 Polymorphism is Associated with the Apoptosis Status of Nucleus Pulposus Cells and the Risk of Intervertebral Disc Degeneration

(2016) Jin Feng Ma et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MiR-138-5p promotes TNF-α-induced apoptosis in human intervertebral disc degeneration by targeting SIRT1 through PTEN/PI3K/Akt signaling

(2016) Bing Wang et al.   EXPERIMENTAL CELL RESEARCH

Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells

(2016) Ann Ouyang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Theo Vos et al.   LANCET

Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration

(2016) Stephen M. Richardson et al.   METHODS

Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis

(2016) Bo Wang et al.   MOLECULAR THERAPY

Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4

(2016) J Xiao et al.   Cell Death & Disease

Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

(2016) Chi Lam Au Yeung et al.   Nature Communications

Intervertebral Disc Engineering through Exploiting Mesenchymal Stem Cells: Progress and Perspective

(2016) Wai-Kit Tam et al.   Current Stem Cell Research & Therapy

Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

(2016) Weijia Sun et al.   Cell Discovery

MicroRNA-494 inhibition protects nucleus pulposus cells from TNF-α-induced apoptosis by targeting JunD

(2015) Tao Wang et al.   BIOCHIMIE

Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection

(2015) Bin Yu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Dysregulated miR-98 Contributes to Extracellular Matrix Degradation by Targeting IL-6/STAT3 Signaling Pathway in Human Intervertebral Disc Degeneration

(2015) Ming-liang Ji et al.   JOURNAL OF BONE AND MINERAL RESEARCH

PTEN Overexpression Cooperates With Lithium to Reduce the Malignancy and to Increase Cell Death by Apoptosis via PI3K/Akt Suppression in Colorectal Cancer Cells

(2015) Wallace Martins de Araujo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MiR-21 overexpression improves osteoporosis by targeting RECK

(2015) Weigong Zhao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

(2015) Sweta Rani et al.   MOLECULAR THERAPY

DIANA-miRPath v3.0: deciphering microRNA function with experimental support

(2015) Ioannis S. Vlachos et al.   NUCLEIC ACIDS RESEARCH

A set of NF-κB–regulated microRNAs induces acquired TRAIL resistance in Lung cancer

(2015) Young-Jun Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Turning 21: Induction of miR-21 as a Key Switch in the Inflammatory Response

(2015) Frederick J. Sheedy   Frontiers in Immunology

Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction

(2014) L. Barile et al.   CARDIOVASCULAR RESEARCH

miR-21 Promotes Human Nucleus Pulposus Cell Proliferation through PTEN/AKT Signaling

(2014) Hongzhe Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A comparison of intravenous and intradiscal delivery of multipotential stem cells on the healing of injured intervertebral disk

(2014) Vivian Tam et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

A Systematic Review of Preclinical Studies on the Therapeutic Potential of Mesenchymal Stromal Cell-Derived Microvesicles

(2014) Celine Akyurekli et al.   Stem Cell Reviews and Reports

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy

(2014) Ahmed Gamal-Eldin Ibrahim et al.   Stem Cell Reports

Cell death in intervertebral disc degeneration

(2013) Fan Ding et al.   APOPTOSIS

Proteomic techniques for characterisation of mesenchymal stem cell secretome

(2013) Helena Kupcova Skalnikova   BIOCHIMIE

Intervertebral disc regeneration: from the degenerative cascade to molecular therapy and tissue engineering

(2013) Gianluca Vadalà et al.   Journal of Tissue Engineering and Regenerative Medicine

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

MiR-27a Regulates Apoptosis in Nucleus Pulposus Cells by Targeting PI3K

(2013) Gang Liu et al.   PLoS One

The Transpedicular Approach As an Alternative Route for Intervertebral Disc Regeneration

(2013) Gianluca Vadalà et al.   SPINE

Substance P Stimulates Production of Inflammatory Cytokines in Human Disc Cells

(2013) Christopher K. Kepler et al.   SPINE

The effects of microenvironment in mesenchymal stem cell–based regeneration of intervertebral disc

(2013) Yong-Can Huang et al.   Spine Journal

Tumor necrosis factor α suppresses the mesenchymal stem cell osteogenesis promoter miR-21 in estrogen deficiency-induced osteoporosis

(2012) Nan Yang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bi-Directional Exchange of Membrane Components Occurs during Co-Culture of Mesenchymal Stem Cells and Nucleus Pulposus Cells

(2012) Sandra Strassburg et al.   PLoS One

Tumor Necrosis Factor-α-Activated Human Adipose Tissue–Derived Mesenchymal Stem Cells Accelerate Cutaneous Wound Healing through Paracrine Mechanisms

(2011) Soon Chul Heo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3

(2011) Hai-Qiang Wang et al.   JOURNAL OF PATHOLOGY

Regulation and function of miRNA-21 in health and disease

(2011) Regalla Kumarswamy et al.   RNA Biology

Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair

(2010) Yufang Shi et al.   CELL RESEARCH

Tumor necrosis factor alpha promotes the expression of immunosuppressive proteins and enhances the cell growth in a human bone marrow-derived stem cell culture

(2010) Johanna A. Miettinen et al.   EXPERIMENTAL CELL RESEARCH

Co-culture induces mesenchymal stem cell differentiation and modulation of the degenerate human nucleus pulposus cell phenotype

(2010) Sandra Strassburg et al.   Regenerative Medicine

Transplanted mesenchymal stem cells with pure fibrinous gelatin-transforming growth factor-β1 decrease rabbit intervertebral disc degeneration

(2010) Huilin Yang et al.   Spine Journal

Developing consistently reproducible intervertebral disc degeneration at rat caudal spine by using needle puncture

(2009) Huina Zhang et al.   JOURNAL OF NEUROSURGERY-SPINE

Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs

(2009) Tian Sheng Chen et al.   NUCLEIC ACIDS RESEARCH

The Effect of Relative Needle Diameter in Puncture and Sham Injection Animal Models of Degeneration

(2009) Dawn M. Elliott et al.   SPINE

In Vitro Study on Interaction Between Human Nucleus Pulposus Cells and Mesenchymal Stem Cells Through Paracrine Stimulation

(2008) Shu-Hua Yang et al.   SPINE