Painful, degenerating intervertebral discs up-regulate neurite sprouting and CGRP through nociceptive factors

Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain

(2013) Satoshi Imai et al.   BRAIN

P38 mitogen-activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture

(2013) Derek H. Rosenzweig et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Transcriptional Mechanisms Underlying Sensitization of Peripheral Sensory Neurons by Granulocyte-/Granulocyte-Macrophage Colony Stimulating Factors

(2013) Kiran Kumar Bali et al.   Molecular Pain

Nerve growth factor: an update on the science and therapy

(2013) M.F. Seidel et al.   OSTEOARTHRITIS AND CARTILAGE

Efficacy and safety of tanezumab versus naproxen in the treatment of chronic low back pain

(2013) Alan J. Kivitz et al.   PAIN

Expression and Relationship of Proinflammatory Chemokine RANTES/CCL5 and Cytokine IL-1β in Painful Human Intervertebral Discs

(2013) Christopher K. Kepler et al.   SPINE

Spinal interleukin-6 is an amplifier of arthritic pain in the rat

(2012) Enrique Vazquez et al.   ARTHRITIS AND RHEUMATISM

Interleukin 1-beta upregulates brain-derived neurotrophic factor, neurotrophin 3 and neuropilin 2 gene expression and NGF production in annulus cells

(2012) HE Gruber et al.   BIOTECHNIC & HISTOCHEMISTRY

Expression of neural and neurotrophic markers in nucleus pulposus cells isolated from degenerated intervertebral disc

(2012) Stefania E. Navone et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Transforming Growth Factor Beta Induces Sensory Neuronal Hyperexcitability, and Contributes to Pancreatic Pain and Hyperalgesia in Rats with Chronic Pancreatitis

(2012) Yaohui Zhu et al.   Molecular Pain

Degenerate Human Nucleus Pulposus Cells Promote Neurite Outgrowth in Neural Cells

(2012) Stephen M. Richardson et al.   PLoS One

ISSLS Prize Winner

(2012) Masayuki Miyagi et al.   SPINE

Control of Arthritis Pain with Anti–Nerve-Growth Factor: Risk and Benefit

(2012) Matthias F. Seidel et al.   Current Rheumatology Reports

Inflammation Confers Dual Effects on Nociceptive Processing in Chronic Neuropathic Pain Model

(2011) Jiin-Tarng Liou et al.   ANESTHESIOLOGY

Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain

(2011) Sumihisa Orita et al.   BMC MUSCULOSKELETAL DISORDERS

Development of an intact intervertebral disc organ culture system in which degeneration can be induced as a prelude to studying repair potential

(2011) Bernice Jim et al.   EUROPEAN SPINE JOURNAL

CGRP: Sensory neuropeptide with multiple neurologic implications

(2011) E. E. Benarroch   NEUROLOGY

Development of an Organ Culture System for Long-Term Survival of the Intact Human Intervertebral Disc

(2011) Rahul Gawri et al.   SPINE

Disk Injury in Rats Produces Persistent Increases in Pain-Related Neuropeptides in Dorsal Root Ganglia and Spinal Cord Glia but Only Transient Increases in Inflammatory Mediators

(2011) Masayuki Miyagi et al.   SPINE

Annulus Fibrosus Cells Interact With Neuron-Like Cells to Modulate Production of Growth Factors and Cytokines in Symptomatic Disc Degeneration

(2011) Hong Joo Moon et al.   SPINE

Experimental arthritis induced by continuous infusion of IL-8 into rabbit knee joints

(2010) H. ENDO et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inhibiting nerve growth factor or its receptors downregulates calcitonin gene-related peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs

(2010) Sumihisa Orita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Timing-Dependent Actions of NGF Required for Cell Differentiation

(2010) Jaehoon Chung et al.   PLoS One

Annulus cells from more degenerated human discs show modified gene expression in 3D culture compared with expression in cells from healthier discs

(2010) Helen E. Gruber et al.   Spine Journal

NF-κB Mediated Enhancement of Potassium Currents by the Chemokine CXCL1/Growth Related Oncogene in Small Diameter Rat Sensory Neurons

(2009) Rui-Hua Yang et al.   Molecular Pain

Nerve Growth Factor of Cultured Medium Extracted From Human Degenerative Nucleus Pulposus Promotes Sensory Nerve Growth and Induces Substance P In Vitro

(2009) Kazuyo Yamauchi et al.   SPINE

Pro-inflammatory, Pleiotropic, and Anti-inflammatory TNF-α, IL-6, and IL-10 in Experimental Porcine Intervertebral Disk Degeneration

(2009) S. Holm et al.   VETERINARY PATHOLOGY

Enhancing and Regulating Neurite Outgrowth

(2008) Edward J. Calabrese   CRITICAL REVIEWS IN TOXICOLOGY

The Chemokine CXCL1/Growth Related Oncogene Increases Sodium Currents and Neuronal Excitability in Small Diameter Sensory Neurons

(2008) Jun-Gang Wang et al.   Molecular Pain

Spinal injection of IL-2 or IL-15 alters mechanical and thermal withdrawal thresholds in rats

(2008) Juan P. Cata et al.   NEUROSCIENCE LETTERS

TNF-Alpha in Nucleus Pulposus Induces Sensory Nerve Growth

(2008) Shinu Hayashi et al.   SPINE

Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc

(2008) Devina Purmessur et al.   ARTHRITIS RESEARCH & THERAPY