Functional crosstalk between T cells and monocytes in cancer and atherosclerosis

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes

(2020) Mirjana Efremova et al.   Nature Protocols

Targeted deletion of PD-1 in myeloid cells induces antitumor immunity

(2020) Laura Strauss et al.   Science Immunology

Single-cell RNA sequencing in cardiovascular development, disease and medicine

(2020) David T. Paik et al.   Nature Reviews Cardiology

Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer

(2019) Sunil Singhal et al.   Science Translational Medicine

T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword

(2019) Karin H. Simons et al.   Nature Reviews Cardiology

Monocyte heterogeneity and functions in cancer

(2019) Claire E. Olingy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

(2019) Luca Cassetta et al.   CANCER CELL

Nonclassical Monocytes in Health and Disease

(2019) Prakash Babu Narasimhan et al.   Annual Review of Immunology

Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity

(2019) Mikhail Binnewies et al.   CELL

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

Tuning the Tumor Myeloid Microenvironment to Fight Cancer

(2019) Nadine S. Jahchan et al.   Frontiers in Immunology

PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function

(2019) Mariaelvy Bianchini et al.   Science Immunology

Atherosclerosis

(2019) Peter Libby et al.   Nature Reviews Disease Primers

Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation

(2019) Marco Di Gioia et al.   NATURE IMMUNOLOGY

Single-cell immune landscape of human atherosclerotic plaques

(2019) Dawn M. Fernandez et al.   NATURE MEDICINE

Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung

(2019) Joey Schyns et al.   Nature Communications

Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses

(2019) Min-Nung Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine AtherosclerosisNovelty and Significance

(2018) Clément Cochain et al.   CIRCULATION RESEARCH

Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass CytometryNovelty and Significance

(2018) Holger Winkels et al.   CIRCULATION RESEARCH

Atherosclerosis in the single-cell era

(2018) Holger Winkels et al.   CURRENT OPINION IN LIPIDOLOGY

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c + CD103 + Monocytic Antigen-Presenting Cells in Tumors

(2018) Madhav D. Sharma et al.   IMMUNITY

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Transcript-indexed ATAC-seq for precision immune profiling

(2018) Ansuman T. Satpathy et al.   NATURE MEDICINE

High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

(2018) Carsten Krieg et al.   NATURE MEDICINE

Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes

(2018) Clare L. V. Westhorpe et al.   Nature Communications

Monocytes Differentiate to Immune Suppressive Precursors of Metastasis-Associated Macrophages in Mouse Models of Metastatic Breast Cancer

(2018) Takanori Kitamura et al.   Frontiers in Immunology

Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging

(2018) Yury Goltsev et al.   CELL

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry

(2018) Anouk A.J. Hamers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics

(2018) Manu P. Kumar et al.   Cell Reports

Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation Potential: A Counterpart of Mouse cMoPs

(2017) Shunsuke Kawamura et al.   IMMUNITY

Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C − Cells

(2017) Alexander Mildner et al.   IMMUNITY

The fate and lifespan of human monocyte subsets in steady state and systemic inflammation

(2017) Amit A. Patel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Clinical significance of costimulatory molecules CD40/CD40L and CD134/CD134L in coronary heart disease

(2017) Jun Chen et al.   MEDICINE

Simultaneous epitope and transcriptome measurement in single cells

(2017) Marlon Stoeckius et al.   NATURE METHODS

The immunology of atherosclerosis

(2017) Anton Gisterå et al.   Nature Reviews Nephrology

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present

(2017) Jianpeng Sheng et al.   Cell Reports

Critical Role for CD103 + /CD141 + Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

(2016) Edward W. Roberts et al.   CANCER CELL

Adaptive Response of T and B Cells in Atherosclerosis

(2016) Daniel F.J. Ketelhuth et al.   CIRCULATION RESEARCH

Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6C low Monocytes while Preserving Macrophage Gene Function

(2016) Graham D. Thomas et al.   IMMUNITY

The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells

(2016) Shinelle Menezes et al.   IMMUNITY

Visualization of immediate immune responses to pioneer metastatic cells in the lung

(2016) Mark B. Headley et al.   NATURE

New insights into the multidimensional concept of macrophage ontogeny, activation and function

(2016) Florent Ginhoux et al.   NATURE IMMUNOLOGY

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling

(2016) Jaba Gamrekelashvili et al.   Nature Communications

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

The “Intermediate” CD14++CD16+ monocyte subset increases in severe peripheral artery disease in humans

(2016) Moritz Wildgruber et al.   Scientific Reports

M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

(2015) E. Van Overmeire et al.   CANCER RESEARCH

Association of Serum Lipids and Coronary Heart Disease in Contemporary Observational Studies

(2015) Lisandro D. Colantonio et al.   CIRCULATION

CD8+T Cells Regulate Monopoiesis and Circulating Ly6ChighMonocyte Levels in Atherosclerosis in MiceNovelty and Significance

(2015) Clément Cochain et al.   CIRCULATION RESEARCH

Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma

(2015) Xiaoguang Li et al.   GUT

Patrolling monocytes control tumor metastasis to the lung

(2015) R. N. Hanna et al.   SCIENCE

Ablation of CD8α+ dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice

(2015) Bart Legein et al.   Scientific Reports

CD40 Generation 2.5 Antisense Oligonucleotide Treatment Attenuates Doxorubicin-induced Nephropathy and Kidney Inflammation

(2015) Aaron J Donner et al.   Molecular Therapy-Nucleic Acids

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

Cytotoxic CD8+ T Cells Stimulate Hematopoietic Progenitors by Promoting Cytokine Release from Bone Marrow Mesenchymal Stromal Cells

(2014) Christian M. Schürch et al.   Cell Stem Cell

Molecular Profiling Reveals a Tumor-Promoting Phenotype of Monocytes and Macrophages in Human Cancer Progression

(2014) Manesh Chittezhath et al.   IMMUNITY

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal

(2013) Leo M. Carlin et al.   CELL

Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis

(2013) D. E. Sanford et al.   CLINICAL CANCER RESEARCH

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

(2013) Claudia Jakubzick et al.   IMMUNITY

Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen

(2013) Maud Plantinga et al.   IMMUNITY

Origin of monocytes and macrophages in a committed progenitor

(2013) Jan Hettinger et al.   NATURE IMMUNOLOGY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Inflammatory monocytes are potent antitumor effectors controlled by regulatory CD4+ T cells

(2013) A. Pommier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

(2012) J. B. Mitchem et al.   CANCER RESEARCH

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Dynamic T cell–APC interactions sustain chronic inflammation in atherosclerosis

(2012) Ekaterina K. Koltsova et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-Infiltrating Monocytic Myeloid-Derived Suppressor Cells Mediate CCR5-Dependent Recruitment of Regulatory T Cells Favoring Tumor Growth

(2012) E. Schlecker et al.   JOURNAL OF IMMUNOLOGY

TAP1-Deficiency Does Not Alter Atherosclerosis Development in Apoe−/− Mice

(2012) Daniel Kolbus et al.   PLoS One

Impairment of the Programmed Cell Death-1 Pathway Increases Atherosclerotic Lesion Development and Inflammation

(2011) De-xiu Bu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis

(2011) Richard N. Hanna et al.   CIRCULATION RESEARCH

CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice

(2011) Christian Weber et al.   JOURNAL OF CLINICAL INVESTIGATION

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes

(2011) Richard N Hanna et al.   NATURE IMMUNOLOGY

CD11c/CD18 Expression Is Upregulated on Blood Monocytes During Hypertriglyceridemia and Enhances Adhesion to Vascular Cell Adhesion Molecule-1

(2010) R. Michael Gower et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

OX40 ligand plays an important role in the development of atherosclerosis through vasa vasorum neovascularization

(2010) M. Nakano et al.   CARDIOVASCULAR RESEARCH

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Inflammatory cytokines as a third signal for T cell activation

(2010) Julie M Curtsinger et al.   CURRENT OPINION IN IMMUNOLOGY

Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis

(2010) Andreas Hermansson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

OX40 Ligand Regulates Inflammation and Mortality in the Innate Immune Response to Sepsis

(2010) M. Karulf et al.   JOURNAL OF IMMUNOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

(2009) Cedric Auffray et al.   Annual Review of Immunology

Immune Stimulatory Receptor CD40 Is Required for T-Cell Suppression and T Regulatory Cell Activation Mediated by Myeloid-Derived Suppressor Cells in Cancer

(2009) P.-Y. Pan et al.   CANCER RESEARCH

Inflammatory Monocytes Facilitate Adaptive CD4 T Cell Responses during Respiratory Fungal Infection

(2009) Tobias M. Hohl et al.   Cell Host & Microbe

Functional Role of CD11c + Monocytes in Atherogenesis Associated With Hypercholesterolemia

(2009) Huaizhu Wu et al.   CIRCULATION

Resident Intimal Dendritic Cells Accumulate Lipid and Contribute to the Initiation of Atherosclerosis

(2009) Kim E. Paulson et al.   CIRCULATION RESEARCH

Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves

(2009) Jae-Hoon Choi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphotoxin β receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of agedApoE−/−mice

(2009) Rolf Gräbner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses

(2009) Hideki Nakano et al.   NATURE IMMUNOLOGY

Respiratory Dendritic Cell Subsets Differ in Their Capacity to Support the Induction of Virus-Specific Cytotoxic CD8+ T Cell Responses

(2009) Taeg S. Kim et al.   PLoS One

Local and systemic induction of CD4+CD25+ regulatory T-cell population by non-Hodgkin lymphoma

(2008) S. Mittal et al.   BLOOD

Myeloid-Derived Suppressor Cells Promote Cross-Tolerance in B-Cell Lymphoma by Expanding Regulatory T Cells

(2008) P. Serafini et al.   CANCER RESEARCH

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

(2008) Christophe Combadière et al.   CIRCULATION

CD11c + Dendritic Cells Maintain Antigen Processing, Presentation Capabilities, and CD4 + T-Cell Priming Efficacy Under Hypercholesterolemic Conditions Associated With Atherosclerosis

(2008) René R.S. Packard et al.   CIRCULATION RESEARCH

Vessel Wall–Embedded Dendritic Cells Induce T-Cell Autoreactivity and Initiate Vascular Inflammation

(2008) Ji W. Han et al.   CIRCULATION RESEARCH

Fractalkine Deficiency Markedly Reduces Macrophage Accumulation and Atherosclerotic Lesion Formation in CCR2 −/− Mice

(2007) Noah Saederup et al.   CIRCULATION