Quercetin‐3‐ O ‐Glucuronide Alleviates Cognitive Deficit and Toxicity in Aβ 1‐42 ‐Induced AD‐Like Mice and SH‐SY5Y Cells

Crosstalk between obesity, diabetes, and alzheimer’s disease: Introducing quercetin as an effective triple herbal medicine

(2020) Shiva Ebrahimpour et al.   AGEING RESEARCH REVIEWS

Yeast β-glucan alleviates cognitive deficit by regulating gut microbiota and metabolites in Aβ1–42-induced AD-like mice

(2020) Mengdai Xu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Jia-Wei-Kai-Xin-San, an Herbal Medicine Formula, Ameliorates Cognitive Deficits via Modulating Metabolism of Beta Amyloid Protein and Neurotrophic Factors in Hippocampus of Aβ1-42 Induced Cognitive Deficit Mice

(2019) Yue Zhu et al.   Frontiers in Pharmacology

The role of short-chain fatty acids in microbiota–gut–brain communication

(2019) Boushra Dalile et al.   Nature Reviews Gastroenterology & Hepatology

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

PQM130, a Novel Feruloyl–Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer’s Disease

(2019) Fabiana Morroni et al.   Frontiers in Pharmacology

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis

(2019) Martin Tolar et al.   Alzheimers & Dementia

Combination of probiotics with different functions alleviate DSS-induced colitis by regulating intestinal microbiota, IL-10, and barrier function

(2019) Yanbo Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

(2019) Woo Shik Shin et al.   Alzheimers Research & Therapy

Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice

(2018) Paul Denver et al.   BRAIN BEHAVIOR AND IMMUNITY

Alteration of the fecal microbiota in Chinese patients with Parkinson’s disease

(2018) Yiwei Qian et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroprotective effects of INT-777 against Aβ 1–42 -induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice

(2018) Xian Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet–Fed Rats

(2018) Sunhye Lee et al.   JOURNAL OF NUTRITION

Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism

(2018) Marion Soto et al.   MOLECULAR PSYCHIATRY

Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer

(2018) Patrice D. Cani et al.   Nature Reviews Gastroenterology & Hepatology

Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier

(2018) Lesley Hoyles et al.   Microbiome

Long-Term Pioglitazone Treatment Improves Learning and Attenuates Pathological Markers in a Mouse Model of Alzheimer's Disease

(2018) James L. Searcy et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s disease

(2018) Richard Hodson   NATURE

Ginsenosides, catechins, quercetin and gut microbiota: Current evidence of challenging interactions

(2018) Rosaria Santangelo et al.   FOOD AND CHEMICAL TOXICOLOGY

Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells

(2018) Monica Bodogai et al.   Science Translational Medicine

Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by Aβ peptides in animal model of Alzheimer’s disease

(2018) Syed Obaidur Rahman et al.   BIOMEDICINE & PHARMACOTHERAPY

EGCG ameliorates high-fat– and high-fructose–induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS

(2017) Yashi Mi et al.   FASEB JOURNAL

Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease

(2017) Ling Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease

(2017) Ramon Velazquez et al.   NEUROBIOLOGY OF AGING

Quercetin-3- O -glucuronide promotes the proliferation and migration of neural stem cells

(2017) Samrat Baral et al.   NEUROBIOLOGY OF AGING

Neuroprotective effects of quercetin in diabetic rat retina

(2017) Mohammad S. Ola et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Animal Models of Alzheimer's Disease: Therapeutic Implications

(2017) Diana S. Woodruff-Pak   JOURNAL OF ALZHEIMERS DISEASE

Grape Derived Polyphenols Attenuate Tau Neuropathology in a Mouse Model of Alzheimer's Disease

(2017) Jun Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

(2017) T. Harach et al.   Scientific Reports

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

(2016) Molly Stanley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

(−)-Epicatechin, a Natural Flavonoid Compound, Protects Astrocytes Against Hemoglobin Toxicity via Nrf2 and AP-1 Signaling Pathways

(2016) Xi Lan et al.   MOLECULAR NEUROBIOLOGY

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Gram-negative bacterial molecules associate with Alzheimer disease pathology

(2016) Xinhua Zhan et al.   NEUROLOGY

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

(2016) Shivani Ghaisas et al.   PHARMACOLOGY & THERAPEUTICS

Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance

(2016) M. J. A. Saad et al.   PHYSIOLOGY

Aβ-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Aβ Secretion in Neural Cells

(2016) Dema Najem et al.   Neuroscience Bulletin

Human gut microbiota: the links with dementia development

(2016) Rashad Alkasir et al.   Protein & Cell

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

(2016) Myles R. Minter et al.   Scientific Reports

Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus

(2015) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Hippocampal insulin resistance and cognitive dysfunction

(2015) Geert Jan Biessels et al.   NATURE REVIEWS NEUROSCIENCE

Metabolic Alterations Associated to Brain Dysfunction in Diabetes

(2015) João M N. Duarte   Aging and Disease

Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer’s disease

(2014) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

(2014) Sergio T. Ferreira et al.   Alzheimers & Dementia

How does brain insulin resistance develop in Alzheimer's disease?

(2014) Fernanda G. De Felice et al.   Alzheimers & Dementia

Selective proliferation of intestinal Barnesiella under fucosyllactose supplementation in mice

(2014) Gisela A. Weiss et al.   BRITISH JOURNAL OF NUTRITION

Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats

(2014) Qing-Yu Zhang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Extremely low frequency electromagnetic field exposure causes cognitive impairment associated with alteration of the glutamate level, MAPK pathway activation and decreased CREB phosphorylation in mice hippocampus: reversal by procyanidins extracted from the lotus seedpod

(2014) Yuqing Duan et al.   Food & Function

Autophagy and gene therapy combine in the treatment of liver disease

(2013) Debra A. Thompson et al.   Autophagy

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Elevation of Brain Magnesium Prevents and Reverses Cognitive Deficits and Synaptic Loss in Alzheimer's Disease Mouse Model

(2013) W. Li et al.   JOURNAL OF NEUROSCIENCE

Quercetin and quercetin-3-O-glucuronide are equally effective in ameliorating endothelial insulin resistance through inhibition of reactive oxygen species-associated inflammation

(2013) Xu-Dan Guo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model

(2013) Jun Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease

(2012) Lap Ho et al.   FASEB JOURNAL

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Acetate reduces microglia inflammatory signalingin vitro

(2012) Mahmoud L. Soliman et al.   JOURNAL OF NEUROCHEMISTRY

Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment

(2012) J. Wang et al.   JOURNAL OF NEUROSCIENCE

Synaptic Stimulation of mTOR Is Mediated by Wnt Signaling and Regulation of Glycogen Synthetase Kinase-3

(2011) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Upregulation of CREB-Mediated Transcription Enhances Both Short- and Long-Term Memory

(2011) A. Suzuki et al.   JOURNAL OF NEUROSCIENCE

Changes in the Nitric Oxide System Contribute to Effect of Procyanidins Extracted from the Lotus Seedpod Ameliorating Memory Impairment in Cognitively Impaired Aged Rats

(2011) Jiqu Xu et al.   REJUVENATION RESEARCH

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Grape-Derived Polyphenolics Prevent A  Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease

(2008) J. Wang et al.   JOURNAL OF NEUROSCIENCE

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

(2008) Shu-Ling Chiu et al.   NEURON