PQM130, a Novel Feruloyl–Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer’s Disease

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

Design, synthesis and pharmacological evaluation of N -benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates

(2018) Flávia Pereira Dias Viegas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advancements toward therapeutic vaccines against alzheimer’s disease

(2018) Krystal Herline et al.   Expert Review of Vaccines

Rosmarinic acid attenuates β-amyloid-induced oxidative stress via Akt/GSK-3β/Fyn-mediated Nrf2 activation in PC12 cells

(2018) Hua Rong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective Effects of 6-(Methylsulfinyl)hexyl Isothiocyanate on Aβ1-42-Induced Cognitive Deficit, Oxidative Stress, Inflammation, and Apoptosis in Mice

(2018) Fabiana Morroni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Riparin II ameliorates corticosterone-induced depressive-like behavior in mice: Role of antioxidant and neurotrophic mechanisms

(2018) Iardja Stéfane Lopes et al.   NEUROCHEMISTRY INTERNATIONAL

The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones

(2018) Matheus de Freitas Silva et al.   MOLECULES

Activation of α7 nicotinic acetylcholine receptor alleviates Aβ1-42-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways

(2018) Ke-Wei Chang et al.   NEUROCHEMISTRY INTERNATIONAL

Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer’s disease

(2018) Masahir Okamoto et al.   Translational Psychiatry

Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer’s Disease Involves Nrf2/HO-1 Pathway

(2018) Fabiana Morroni et al.   Aging and Disease

Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease

(2018) María José Pérez et al.   Redox Biology

Age-associated decline in Nrf2 signaling and associated mtDNA damage may be involved in the degeneration of the auditory cortex: Implications for central presbycusis

(2018) Yongqin Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Combined treatment with the phenolics (−)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in mice

(2018) Takashi Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Nrf2/ARE pathway alleviates the cognitive deficits in PS1V97L-Tg mouse model of Alzheimer’s disease through modulation of oxidative stress

(2018) Yuanruhua Tian et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer’s Disease

(2018) Mikael Marttinen et al.   Frontiers in Neuroscience

Brain-derived neurotrophic factor modified human umbilical cord mesenchymal stem cells-derived cholinergic-like neurons improve spatial learning and memory ability in Alzheimer’s disease rats

(2018) Weiwei Hu et al.   BRAIN RESEARCH

Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease

(2017) Kris Simone T. Dias et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer’s disease

(2017) Caterina Branca et al.   HUMAN MOLECULAR GENETICS

Protective effects of linalool against amyloid beta-induced cognitive deficits and damages in mice

(2017) Pan Xu et al.   LIFE SCIENCES

Curcumin revitalizes Amyloid beta (25–35)-induced and organophosphate pesticides pestered neurotoxicity in SH-SY5Y and IMR-32 cells via activation of APE1 and Nrf2

(2017) Bibekananda Sarkar et al.   METABOLIC BRAIN DISEASE

Early effects of Aβ 1-42 oligomers injection in mice: Involvement of PI3K/Akt/GSK3 and MAPK/ERK1/2 pathways

(2016) Fabiana Morroni et al.   BEHAVIOURAL BRAIN RESEARCH

Stress-induced anhedonia is associated with the activation of the inflammatory system in the rat brain: Restorative effect of pharmacological intervention

(2016) Andrea C. Rossetti et al.   PHARMACOLOGICAL RESEARCH

Characterization of cognitive deficits in mice with an alternating hemiplegia-linked mutation.

(2015) Greer S. Kirshenbaum et al.   BEHAVIORAL NEUROSCIENCE

Oxidative stress response and Nrf2 signaling in aging

(2015) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

In vitro validation of effects of BDNF-expressing mesenchymal stem cells on neurodegeneration in primary cultured neurons of APP/PS1 mice

(2015) M.-S. Song et al.   NEUROSCIENCE

Nootropic, neuroprotective and neurotrophic effects of phloretin in scopolamine induced amnesia in mice

(2015) Priya J. Ghumatkar et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants

(2015) Antonella Sgarbossa et al.   Nutrients

Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease

(2014) Fabiana Morroni et al.   BRAIN RESEARCH

Inflammation and Programmed Cell Death in Alzheimer’s Disease: Comparison of the Central Nervous System and Peripheral Blood

(2014) Beatrice Macchi et al.   MOLECULAR NEUROBIOLOGY

Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues

(2014) M. Obulesu et al.   NEUROCHEMICAL RESEARCH

GSK-3β, a pivotal kinase in Alzheimer disease

(2014) María Llorens-Marítin et al.   Frontiers in Molecular Neuroscience

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell

(2013) Xueqi Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis

(2013) Isabel Lastres-Becker et al.   BRAIN

Biomarker Modeling of Alzheimer’s Disease

(2013) Clifford R. Jack et al.   NEURON

Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivo

(2013) Hyo Geun Kim et al.   NEUROTOXICOLOGY

Deoxyschizandrin Isolated from the Fruits of Schisandra chinensis Ameliorates Aβ1-42-induced Memory Impairment in Mice

(2012) Di Hu et al.   PLANTA MEDICA

Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice

(2011) Yoko Furukawa-Hibi et al.   BEHAVIOURAL BRAIN RESEARCH

Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus

(2011) Timothy R. Chapman et al.   NEUROBIOLOGY OF AGING

Protective Role of Ashwagandha Leaf Extract and Its Component Withanone on Scopolamine-Induced Changes in the Brain and Brain-Derived Cells

(2011) Arpita Konar et al.   PLoS One

REVIEW: Curcumin and Alzheimer's Disease

(2010) Tsuyoshi Hamaguchi et al.   CNS Neuroscience & Therapeutics

4-O-Methylhonokiol attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway

(2010) Young Jung Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

4-O-methylhonokiol attenuated β-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38 MAP kinase

(2010) Yong Kyung Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

l-Theanine, an amino acid in green tea, attenuates β-amyloid-induced cognitive dysfunction and neurotoxicity: Reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-κB pathways

(2009) Tae Il Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress Is Linked to ERK1/2-p16 Signaling-mediated Growth Defect in ATM-deficient Astrocytes

(2009) Jeesun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-Dependent Dendritic Release of BDNF and Biological Consequences

(2009) Nicola Kuczewski et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Review: Therapy for Alzheimer's disease: how effective are current treatments?

(2009) Krista L. Lanctôt et al.   Therapeutic Advances in Neurological Disorders

Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons

(2008) Juan Ji An et al.   CELL

Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE,in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease

(2008) Giovanna Cenini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity

(2008) Andrea Tarozzi et al.   NEUROREPORT

Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease

(2008) Rita M. Ramalho et al.   TRENDS IN MOLECULAR MEDICINE

The anti-amnesic and neuroprotective effects of donepezil against amyloid β25-35 peptide-induced toxicity in mice involve an interaction with the σ1 receptor

(2006) J Meunier et al.   BRITISH JOURNAL OF PHARMACOLOGY