Aβ-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Aβ Secretion in Neural Cells

Insulin resistance, neuroinflammation, and Alzheimer’s disease

(2014) Dema Najem et al.   REVIEWS IN THE NEUROSCIENCES

Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues

(2013) Mizuho Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

(2013) Fernanda G. De Felice   JOURNAL OF CLINICAL INVESTIGATION

Insulin Has Multiple Antiamyloidogenic Effects on Human Neuronal Cells

(2012) Giuseppe Pandini et al.   ENDOCRINOLOGY

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin resistance and AD—extending the translational path

(2012) Suzanne Craft   Nature Reviews Neurology

Isoprenoids, small GTPases and Alzheimer's disease

(2010) Gero P. Hooff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Diabetes and Insulin in Regulation of Brain Cholesterol Metabolism

(2010) Ryo Suzuki et al.   Cell Metabolism

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

(2010) Irfan Y. Tamboli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Seladin-1/DHCR24 protects neuroblastoma cells against Aβ toxicity by increasing membrane cholesterol content

(2010) C. Cecchi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Modulation of Cholesterol, Farnesylpyrophosphate, and Geranylgeranylpyrophosphate in Neuroblastoma SH-SY5Y-APP695 Cells: Impact on Amyloid Beta-Protein Production

(2010) Gero P. Hooff et al.   MOLECULAR NEUROBIOLOGY

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Down-regulation of Seladin-1 Increases BACE1 Levels and Activity through Enhanced GGA3 Depletion during Apoptosis

(2009) Timo Sarajärvi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid

(2009) Han-Kyu Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway

(2009) Vanja Vukic et al.   NEUROBIOLOGY OF DISEASE

3β-Hydroxysteroid-Δ24 Reductase Is a Hydrogen Peroxide Scavenger, Protecting Cells from Oxidative Stress-Induced Apoptosis

(2008) Xiuli Lu et al.   ENDOCRINOLOGY

Central Leptin Regulates Total Ceramide Content and Sterol Regulatory Element Binding Protein-1C Proteolytic Maturation in Rat White Adipose Tissue

(2008) Elena Bonzón-Kulichenko et al.   ENDOCRINOLOGY

Lovastatin inhibits amyloid precursor protein (APP) β-cleavage through reduction of APP distribution in Lubrol WX extractable low density lipid rafts

(2008) Je-Seong Won et al.   JOURNAL OF NEUROCHEMISTRY

Diverse roles of Rho family GTPases in neuronal development, survival, and death

(2007) Daniel et al.   Frontiers in Bioscience-Landmark

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

(2007) Huaqi Xiong et al.   NEUROBIOLOGY OF DISEASE