Collagen Density Modulates the Immunosuppressive Functions of Macrophages

Collagen density regulates the activity of tumor-infiltrating T cells

(2019) Dorota E. Kuczek et al.   Journal for ImmunoTherapy of Cancer

Targeting Macrophages in Cancer: From Bench to Bedside

(2018) Ashleigh R. Poh et al.   Frontiers in Oncology

Cancer cells’ ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential

(2018) Lena Wullkopf et al.   MOLECULAR BIOLOGY OF THE CELL

Early Growth Response Gene-2 Is Essential for M1 and M2 Macrophage Activation and Plasticity by Modulation of the Transcription Factor CEBPβ

(2018) Tatyana Veremeyko et al.   Frontiers in Immunology

Versican modulates tumor-associated macrophage properties to stimulate mesothelioma growth

(2018) Apostolos G. Pappas et al.   OncoImmunology

Versican Promotes Tumor Progression, Metastasis and Predicts Poor Prognosis in Renal Carcinoma

(2017) Yozo Mitsui et al.   MOLECULAR CANCER RESEARCH

ICAM-1 regulates macrophage polarization by suppressing MCP-1 expression via miR-124 upregulation

(2017) Wei Gu et al.   Oncotarget

CD163+CD204+ tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma

(2017) Keigo Kubota et al.   Scientific Reports

The Multifaceted Role of Perivascular Macrophages in Tumors

(2016) Claire E. Lewis et al.   CANCER CELL

Long-Lasting Complete Responses in Patients with Metastatic Melanoma after Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes and an Attenuated IL2 Regimen

(2016) R. Andersen et al.   CLINICAL CANCER RESEARCH

Immune suppressive mechanisms in the tumor microenvironment

(2016) David H Munn et al.   CURRENT OPINION IN IMMUNOLOGY

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

(2016) K. Sadtler et al.   SCIENCE

Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection

(2016) Cole R. Drifka et al.   Oncotarget

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis

(2016) Anna-Maria Georgoudaki et al.   Cell Reports

ADAMTS5 Is a Critical Regulator of Virus-Specific T Cell Immunity

(2016) Meagan McMahon et al.   PLOS BIOLOGY

A novel role of breast cancer-derived hyaluronan on inducement of M2-like tumor-associated macrophages formation

(2016) Guoliang Zhang et al.   OncoImmunology

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis

(2015) Rachel G. Scheraga et al.   JOURNAL OF IMMUNOLOGY

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Three-dimensional in vitro tumor models for cancer research and drug evaluation

(2014) Xian Xu et al.   BIOTECHNOLOGY ADVANCES

Prevailing Role of Contact Guidance in Intrastromal T-cell Trapping in Human Pancreatic Cancer

(2014) N. Hartmann et al.   CLINICAL CANCER RESEARCH

ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs

(2014) P. J. Balwierz et al.   GENOME RESEARCH

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Matrix Stiffening and β 1 Integrin Drive Subtype-Specific Fibroblast Accumulation in Lung Cancer

(2014) Marta Puig et al.   MOLECULAR CANCER RESEARCH

A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients

(2014) Meiying Zhang et al.   Journal of Ovarian Research

Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo

(2013) Nadine Jetten et al.   ANGIOGENESIS

Immune-suppressive properties of the tumor microenvironment

(2013) Jürgen C. Becker et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway

(2013) Daniel H. Madsen et al.   JOURNAL OF CELL BIOLOGY

Expression of αvβ6 integrin and collagen fibre in oral squamous cell carcinoma: association with clinical outcomes and prognostic implications

(2013) Hai-Xia Li et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage Activation

(2013) Mirjam Stahl et al.   PLoS One

Tumor-associated macrophages: functional diversity, clinical significance, and open questions

(2013) Subhra K. Biswas et al.   Seminars in Immunopathology

Collagen as a double-edged sword in tumor progression

(2013) Min Fang et al.   TUMOR BIOLOGY

Matrix Stiffness–Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction

(2012) Xiangwei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Student award winner in the undergraduate category for the society of biomaterials 9th World Biomaterials Congress, Chengdu, China, June 1-5, 2012

(2012) Anna K. Blakney et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Collagen I fiber density increases in lymph node positive breast cancers: pilot study

(2012) Samata M. Kakkad et al.   JOURNAL OF BIOMEDICAL OPTICS

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

(2012) Hélène Salmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell Elasticity Determines Macrophage Function

(2012) Naimish R. Patel et al.   PLoS One

The pros and cons of chemokines in tumor immunology

(2012) Antonella Viola et al.   TRENDS IN IMMUNOLOGY

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Differential Macrophage Polarization Promotes Tissue Remodeling and Repair in a Model of Ischemic Retinopathy

(2011) Valentina Marchetti et al.   Scientific Reports

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Up-regulation of stromal versican expression in advanced stage serous ovarian cancer

(2010) Sue Ghosh et al.   GYNECOLOGIC ONCOLOGY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Prevention of Both Direct and Cross-Priming of Antitumor CD8+ T-Cell Responses following Overproduction of Prostaglandin E2 by Tumor Cells In vivo

(2008) M. Ahmadi et al.   CANCER RESEARCH

Ability of Mature Dendritic Cells to Interact with Regulatory T Cells Is Imprinted during Maturation

(2008) R. Muthuswamy et al.   CANCER RESEARCH