Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice

­­LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation

(2016) Julia Zinngrebe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex

(2016) Yoon Park et al.   NATURE IMMUNOLOGY

Integrin-based therapeutics: biological basis, clinical use and new drugs

(2016) Klaus Ley et al.   NATURE REVIEWS DRUG DISCOVERY

Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling

(2015) Nicola De Franceschi et al.   PLoS One

Epidermal p65/NF- B signalling is essential for skin carcinogenesis

(2014) C. Kim et al.   EMBO Molecular Medicine

IFN-  or IFN-  Ameliorates Chronic Proliferative Dermatitis by Inducing Expression of Linear Ubiquitin Chain Assembly Complex

(2014) H. Tamiya et al.   JOURNAL OF IMMUNOLOGY

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

(2014) James A Rickard et al.   eLife

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

(2014) Snehlata Kumari et al.   eLife

Integrin inactivators: balancing cellular functions in vitro and in vivo

(2013) Daniel Bouvard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SHARPIN Regulates Uropod Detachment in Migrating Lymphocytes

(2013) Jeroen Pouwels et al.   Cell Reports

SHARPIN is a key regulator of immune and inflammatory responses

(2012) Zhe Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

SHARPIN is an endogenous inhibitor of β1-integrin activation

(2011) Juha K. Rantala et al.   NATURE CELL BIOLOGY

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses

(2011) D. E. Zak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique and redundant functions of integrins in the epidermis

(2010) Coert Margadant et al.   FASEB JOURNAL

HOIL-1L Interacting Protein (HOIP) as an NF-κB Regulating Component of the CD40 Signaling Complex

(2010) Bruce S. Hostager et al.   PLoS One

Anti-integrin monoclonal antibodies

(2009) A. Byron et al.   JOURNAL OF CELL SCIENCE

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY