DYRK1A Inhibitors as Potential Therapeutics for β-Cell Regeneration for Diabetes
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
DYRK1A Inhibitors as Potential Therapeutics for β-Cell Regeneration for Diabetes
Authors
Keywords
-
Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume -, Issue -, Pages -
Publisher
American Chemical Society (ACS)
Online
2021-03-08
DOI
10.1021/acs.jmedchem.0c02050
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Identification of a LIF-Responsive, Replication-Competent Subpopulation of Human β Cells
- (2020) Edwin A. Rosado-Olivieri et al. Cell Metabolism
- Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133
- (2020) Yahu A. Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration
- (2020) Courtney Ackeifi et al. Science Translational Medicine
- The De-, Re-, and trans-differentiation of β-cells: Regulation and function
- (2020) Jingjing Zhang et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells
- (2020) Miseon Lee et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structure–Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human β-Cell Proliferation
- (2020) Kunal Kumar et al. MOLECULES
- A Dual Inhibitor of DYRK1A and GSK3β for β‐Cell Proliferation: Aminopyrazine Derivative GNF4877
- (2020) Yahu A. Liu et al. ChemMedChem
- Peptide Conjugates with Small Molecules Designed to Enhance Efficacy and Safety
- (2019) Rongjun He et al. MOLECULES
- An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes
- (2019) Kevan C. Herold et al. NEW ENGLAND JOURNAL OF MEDICINE
- YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells
- (2019) Edwin A. Rosado-Olivieri et al. Nature Communications
- Changing the landscape for type 1 diabetes: the first step to prevention
- (2019) Colin M Dayan et al. LANCET
- Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization
- (2019) Paul A. Allegretti et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1
- (2018) Daniel J. Drucker Cell Metabolism
- Advances in drug discovery for human beta cell regeneration
- (2018) Esra Karakose et al. DIABETOLOGIA
- Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) Inhibitors as Potential Therapeutics
- (2018) Dnyandev B. Jarhad et al. JOURNAL OF MEDICINAL CHEMISTRY
- Parathyroid Hormone for Bone Regeneration
- (2018) Samantha J. Wojda et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity
- (2018) Kunal Kumar et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Development of Kinase-Selective, Harmine-Based DYRK1A Inhibitors that Induce Pancreatic Human β-Cell Proliferation
- (2018) Kunal Kumar et al. JOURNAL OF MEDICINAL CHEMISTRY
- Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis
- (2018) Diane C. Saunders et al. Cell Metabolism
- Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells
- (2018) Peng Wang et al. Cell Metabolism
- Antibody-drug conjugates (ADCs) for cancer therapy: Strategies, challenges, and successes
- (2018) Meghdad Abdollahpour-Alitappeh et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Generation of pancreatic β cells for treatment of diabetes: advances and challenges
- (2018) Hussain Md. Shahjalal et al. Stem Cell Research & Therapy
- Targeted delivery of antisense oligonucleotides to pancreatic β-cells
- (2018) C. Ämmälä et al. Science Advances
- FDA-Approved Oligonucleotide Therapies in 2017
- (2017) Cy A. Stein et al. MOLECULAR THERAPY
- The chemical evolution of oligonucleotide therapies of clinical utility
- (2017) Anastasia Khvorova et al. NATURE BIOTECHNOLOGY
- Strategies and challenges for the next generation of antibody–drug conjugates
- (2017) Alain Beck et al. NATURE REVIEWS DRUG DISCOVERY
- Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs
- (2017) Xiulong Shen et al. NUCLEIC ACIDS RESEARCH
- In situ click chemistry generation of cyclooxygenase-2 inhibitors
- (2017) Atul Bhardwaj et al. Nature Communications
- Engineering growth factors for regenerative medicine applications
- (2016) Aaron C. Mitchell et al. Acta Biomaterialia
- Techniques for measuring cellular zinc
- (2016) Margaret C. Carpenter et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure
- (2016) P. G. Richardson et al. BLOOD
- SerpinB1 Promotes Pancreatic β Cell Proliferation
- (2016) Abdelfattah El Ouaamari et al. Cell Metabolism
- Pancreas-Specific Delivery of β-Cell Proliferating Small Molecules
- (2016) Xueshi Hao et al. ChemMedChem
- Inhibition of DYRK1A Stimulates Human β-Cell Proliferation
- (2016) Ercument Dirice et al. DIABETES
- Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication
- (2016) Sangeeta Dhawan et al. DIABETES
- Novel factors modulating human β-cell proliferation
- (2016) J. Shirakawa et al. DIABETES OBESITY & METABOLISM
- High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation
- (2016) Karine Robitaille et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeted Delivery of an Anti-inflammatory PDE4 Inhibitor to Immune Cells via an Antibody–drug Conjugate
- (2016) Shan Yu et al. MOLECULAR THERAPY
- Induced pluripotent stem cell technology: a decade of progress
- (2016) Yanhong Shi et al. NATURE REVIEWS DRUG DISCOVERY
- Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides
- (2015) Richard S. Geary et al. ADVANCED DRUG DELIVERY REVIEWS
- Targeted Delivery of LXR Agonist Using a Site-Specific Antibody–Drug Conjugate
- (2015) Reyna K. V. Lim et al. BIOCONJUGATE CHEMISTRY
- Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway
- (2015) Nagesha Guthalu Kondegowda et al. Cell Metabolism
- Leukemia inhibitory factor (LIF)
- (2015) Nicos A. Nicola et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion
- (2015) Maria L. Golson et al. DIABETES
- Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes
- (2015) Martha Campbell-Thompson et al. DIABETES
- Novel antibody–antibiotic conjugate eliminates intracellular S. aureus
- (2015) Sophie M. Lehar et al. NATURE
- A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication
- (2015) Peng Wang et al. NATURE MEDICINE
- Diabetes mellitus—advances and challenges in human β-cell proliferation
- (2015) Peng Wang et al. Nature Reviews Endocrinology
- Inhibition of DYRK1A and GSK3B induces human β-cell proliferation
- (2015) Weijun Shen et al. Nature Communications
- Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia
- (2015) Houda Alachkar et al. Oncotarget
- DFGmodel: Predicting Protein Kinase Structures in Inactive States for Structure-Based Discovery of Type-II Inhibitors
- (2014) Peter Man-Un Ung et al. ACS Chemical Biology
- GABA Promotes Human -Cell Proliferation and Modulates Glucose Homeostasis
- (2014) I. Purwana et al. DIABETES
- Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass
- (2014) Latif Rachdi et al. DIABETOLOGIA
- Targeting the pancreatic β-cell to treat diabetes
- (2014) Amedeo Vetere et al. NATURE REVIEWS DRUG DISCOVERY
- Immune modulation in humans: implications for type 1 diabetes mellitus
- (2014) Bart O. Roep et al. Nature Reviews Endocrinology
- A Smad Signaling Network Regulates Islet Cell Proliferation
- (2013) Y. El-Gohary et al. DIABETES
- Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening
- (2013) Weijun Shen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Site-specific antibody drug conjugates for cancer therapy
- (2013) Siler Panowski et al. mAbs
- The role of estrogen and androgen receptors in bone health and disease
- (2013) Stavros C. Manolagas et al. Nature Reviews Endocrinology
- MELK-Dependent FOXM1 Phosphorylation is Essential for Proliferation of Glioma Stem Cells
- (2013) Kaushal Joshi et al. STEM CELLS
- A VGF-Derived Peptide Attenuates Development of Type 2 Diabetes via Enhancement of Islet β-Cell Survival and Function
- (2012) Samuel B. Stephens et al. Cell Metabolism
- Neonatal β Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT
- (2012) William R. Goodyer et al. DEVELOPMENTAL CELL
- Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life
- (2012) Brigid E. Gregg et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Discovery of Novel Potent and Highly Selective Glycogen Synthase Kinase-3β (GSK3β) Inhibitors for Alzheimer’s Disease: Design, Synthesis, and Characterization of Pyrazines
- (2012) Stefan Berg et al. JOURNAL OF MEDICINAL CHEMISTRY
- Adenosine kinase inhibition selectively promotes rodent and porcine islet -cell replication
- (2012) J. P. Annes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Developments in harmine pharmacology — Implications for ayahuasca use and drug-dependence treatment
- (2012) Daniel I. Brierley et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing
- (2011) Mansour Debdab et al. JOURNAL OF MEDICINAL CHEMISTRY
- Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR)
- (2011) D. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Stunned β Cell: A Brief History
- (2010) Ele Ferrannini Cell Metabolism
- In vitro phage display in a rat beta cell line: a simple approach for the generation of a single-chain antibody targeting a novel beta cell-specific epitope
- (2010) S. Ueberberg et al. DIABETOLOGIA
- Genetics, pathogenesis and clinical interventions in type 1 diabetes
- (2010) Jeffrey A. Bluestone et al. NATURE
- Emerging roles for the TGFβ family in pancreatic β-cell homeostasis
- (2010) Melissa L. Brown et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A
- (2010) Yasushi Ogawa et al. Nature Communications
- Identification of small-molecule inducers of pancreatic -cell expansion
- (2009) W. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of -Cell Mass in Humans
- (2008) J. J. Meier et al. DIABETES
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search