GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration

CRISPR/Cas9 technology as a potent molecular tool for gene therapy

(2019) Ansar Karimian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder

(2018) Ajay Major et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Incretin-based therapies and risk of pancreatic cancer in patients with type 2 diabetes: A meta-analysis of randomized controlled trials

(2018) Haining Wang et al.   DIABETES OBESITY & METABOLISM

Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity

(2018) Kunal Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of Kinase-Selective, Harmine-Based DYRK1A Inhibitors that Induce Pancreatic Human β-Cell Proliferation

(2018) Kunal Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells

(2018) Peng Wang et al.   Cell Metabolism

Use of human islets to understand islet biology and diabetes: progress, challenges and suggestions

(2018) Nathaniel J. Hart et al.   DIABETOLOGIA

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling

(2017) Chunhua Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas

(2017) Huan Wang et al.   Nature Communications

The tumorigenic potential of pluripotent stem cells: What can we do to minimize it?

(2016) Suzanne E. Peterson et al.   BIOESSAYS

SerpinB1 Promotes Pancreatic β Cell Proliferation

(2016) Abdelfattah El Ouaamari et al.   Cell Metabolism

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

(2016) Ercument Dirice et al.   DIABETES

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway

(2015) Nagesha Guthalu Kondegowda et al.   Cell Metabolism

The value of short- and long-acting glucagon-like peptide-1 agonists in the management of type 2 diabetes mellitus: experience with exenatide

(2015) Xiao-Hui Guo   CURRENT MEDICAL RESEARCH AND OPINION

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

(2015) Weijun Shen et al.   Nature Communications

A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress

(2015) Jong Woo Lee et al.   PLoS One

GABA Promotes Human  -Cell Proliferation and Modulates Glucose Homeostasis

(2014) I. Purwana et al.   DIABETES

GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody

(2014) Charles Pyke et al.   ENDOCRINOLOGY

Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors

(2013) A. E. Butler et al.   DIABETES

Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: comparison, efficacy and safety

(2013) Carolyn F Deacon et al.   EXPERT OPINION ON PHARMACOTHERAPY

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans

(2013) Stefan Amisten et al.   PHARMACOLOGY & THERAPEUTICS

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

A VGF-Derived Peptide Attenuates Development of Type 2 Diabetes via Enhancement of Islet β-Cell Survival and Function

(2012) Samuel B. Stephens et al.   Cell Metabolism

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

(2012) Tania Tahtouh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Developments in harmine pharmacology — Implications for ayahuasca use and drug-dependence treatment

(2012) Daniel I. Brierley et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Regulated and Reversible Induction of Adult Human  -Cell Replication

(2011) K. K. Takane et al.   DIABETES

INS GFP/w human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells

(2011) S. J. Micallef et al.   DIABETOLOGIA

Parathyroid Hormone-Related Protein Enhances Human  -Cell Proliferation and Function With Associated Induction of Cyclin-Dependent Kinase 2 and Cyclin E Expression

(2010) N. Guthalu Kondegowda et al.   DIABETES

Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6

(2010) Nathalie M. Fiaschi-Taesch et al.   DIABETES

Molecular and Immunologic Mechanisms of Cancer Pathogenesis in Solid Organ Transplant Recipients

(2008) O. M. Martinez et al.   AMERICAN JOURNAL OF TRANSPLANTATION