High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation

Role of genetics in lung transplant complications

(2015) D. Ruttens et al.   ANNALS OF MEDICINE

Liver transplantation in the context of organ shortage

(2015) Valerio Lucidi et al.   Current Opinion in Critical Care

Changing paradigms in organ preservation and resuscitation

(2015) Fadwa Ali et al.   Current Opinion in Organ Transplantation

LKB1 couples glucose metabolism to insulin secretion in mice

(2015) Accalia Fu et al.   DIABETOLOGIA

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

(2015) Cameron McDonald-Hyman et al.   Science Translational Medicine

The perfect storm: HLA antibodies, complement, FcγRs, and endothelium in transplant rejection

(2015) Kimberly A. Thomas et al.   TRENDS IN MOLECULAR MEDICINE

Targeting the cell cycle inhibitor p57Kip2 promotes adult human β cell replication

(2014) Dana Avrahami et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of the SIK2–p35–PJA2 complex in pancreatic β-cell functional compensation

(2014) Jun-Ichi Sakamaki et al.   NATURE CELL BIOLOGY

Effects of surface camouflaged islet transplantation on pathophysiological progression in a db/db type 2 diabetic mouse model

(2013) Jee-Heon Jeong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Finding effective cancer therapies through loss of function genetic screens

(2013) René Bernards   CURRENT OPINION IN GENETICS & DEVELOPMENT

Human Pancreatic  -Cell G1/S Molecule Cell Cycle Atlas

(2013) N. M. Fiaschi-Taesch et al.   DIABETES

Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets

(2013) A. Beck et al.   DIABETOLOGIA

CRTC2 Is Required for β-Cell Function and Proliferation

(2013) Chandra E. Eberhard et al.   ENDOCRINOLOGY

Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening

(2013) Weijun Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Toward clinical islet xenotransplantation - are revisions to the IXA guidelines warranted?

(2013) David K.C. Cooper et al.   XENOTRANSPLANTATION

The negative cell cycle regulators, p27Kip1, p18Ink4c, and GSK-3, play critical role in maintaining quiescence of adult human pancreaticβ-cells and restrict their ability to proliferate

(2013) Jeffrey Stein et al.   Islets

Human  -Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

(2012) R. N. Kulkarni et al.   DIABETES

Genomic Screening with RNAi: Results and Challenges

(2010) Stephanie Mohr et al.   Annual Review of Biochemistry

Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6

(2010) Nathalie M. Fiaschi-Taesch et al.   DIABETES

Novel trends in high-throughput screening

(2009) Lorenz M Mayr et al.   CURRENT OPINION IN PHARMACOLOGY

Survey of the Human Pancreatic  -Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D1 in Enhancing Human  -Cell Replication and Function In Vivo

(2009) N. Fiaschi-Taesch et al.   DIABETES

Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines

(2008) I. Cozar-Castellano et al.   DIABETES

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES

Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2

(2008) D. Jansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA